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Am J Hum Genet. Oct 1998; 63(4): 935–941.
PMCID: PMC1377509

Transmission disequilibrium, family controls, and great expectations.

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Selected References

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  • Allison DB. Transmission-disequilibrium tests for quantitative traits. Am J Hum Genet. 1997 Mar;60(3):676–690. [PMC free article] [PubMed]
  • Bui MM, Luo DF, She JY, Maclaren NK, Muir A, Thomson G, She JX. Paternally transmitted IDDM2 influences diabetes susceptibility despite biallelic expression of the insulin gene in human pancreas. J Autoimmun. 1996 Feb;9(1):97–103. [PubMed]
  • Camp NJ. Genomewide transmission/disequilibrium testing--consideration of the genotypic relative risks at disease loci. Am J Hum Genet. 1997 Dec;61(6):1424–1430. [PMC free article] [PubMed]
  • Cervino AC, Curnow RN. Testing candidate genes that may affect susceptibility to leprosy. Int J Lepr Other Mycobact Dis. 1997 Dec;65(4):456–460. [PubMed]
  • Curtis D, Sham PC. A note on the application of the transmission disequilibrium test when a parent is missing. Am J Hum Genet. 1995 Mar;56(3):811–812. [PMC free article] [PubMed]
  • Ebers GC, Kukay K, Bulman DE, Sadovnick AD, Rice G, Anderson C, Armstrong H, Cousin K, Bell RB, Hader W, et al. A full genome search in multiple sclerosis. Nat Genet. 1996 Aug;13(4):472–476. [PubMed]
  • Ewens WJ, Spielman RS. The transmission/disequilibrium test: history, subdivision, and admixture. Am J Hum Genet. 1995 Aug;57(2):455–464. [PMC free article] [PubMed]
  • Falk CT, Rubinstein P. Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet. 1987 Jul;51(Pt 3):227–233. [PubMed]
  • Jorde LB. Linkage disequilibrium as a gene-mapping tool. Am J Hum Genet. 1995 Jan;56(1):11–14. [PMC free article] [PubMed]
  • Kaplan NL, Martin ER, Morris RW, Weir BS. Marker selection for the transmission/disequilibrium test, in recently admixed populations. Am J Hum Genet. 1998 Mar;62(3):703–712. [PMC free article] [PubMed]
  • Kaplan NL, Martin ER, Weir BS. Power studies for the transmission/disequilibrium tests with multiple alleles. Am J Hum Genet. 1997 Mar;60(3):691–702. [PMC free article] [PubMed]
  • Lazzeroni LC, Lange K. A conditional inference framework for extending the transmission/disequilibrium test. Hum Hered. 1998 Mar-Apr;48(2):67–81. [PubMed]
  • Li T, Sham PC, Vallada H, Xie T, Tang X, Murray RM, Liu X, Collier DA. Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatr Genet. 1996 Fall;6(3):131–133. [PubMed]
  • Maestri NE, Beaty TH, Hetmanski J, Smith EA, McIntosh I, Wyszynski DF, Liang KY, Duffy DL, VanderKolk C. Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models. Am J Med Genet. 1997 Dec 19;73(3):337–344. [PubMed]
  • Marlow A, John S, Hajeer A, Ollier WE, Silman AJ, Worthington J. The sensitivity of different analytical methods to detect disease susceptibility genes in rheumatoid arthritis sibling pair families. J Rheumatol. 1997 Jan;24(1):208–211. [PubMed]
  • Marron MP, Raffel LJ, Garchon HJ, Jacob CO, Serrano-Rios M, Martinez Larrad MT, Teng WP, Park Y, Zhang ZX, Goldstein DR, et al. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum Mol Genet. 1997 Aug;6(8):1275–1282. [PubMed]
  • Martin ER, Kaplan NL, Weir BS. Tests for linkage and association in nuclear families. Am J Hum Genet. 1997 Aug;61(2):439–448. [PMC free article] [PubMed]
  • Merriman T, Twells R, Merriman M, Eaves I, Cox R, Cucca F, McKinney P, Shield J, Baum D, Bosi E, et al. Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21. Hum Mol Genet. 1997 Jul;6(7):1003–1010. [PubMed]
  • Morris AP, Whittaker JC, Curnow RN. A likelihood ratio test for detecting patterns of disease-marker association. Ann Hum Genet. 1997 Jul;61(Pt 4):335–350. [PubMed]
  • Müller-Myhsok B, Abel L. Genetic analysis of complex diseases. Science. 1997 Feb 28;275(5304):1328–1330. [PubMed]
  • Petronzelli F, Bonamico M, Ferrante P, Grillo R, Mora B, Mariani P, Apollonio I, Gemme G, Mazzilli MC. Genetic contribution of the HLA region to the familial clustering of coeliac disease. Ann Hum Genet. 1997 Jul;61(Pt 4):307–317. [PubMed]
  • Rabinowitz D. A transmission disequilibrium test for quantitative trait loci. Hum Hered. 1997 Nov-Dec;47(6):342–350. [PubMed]
  • Reed P, Cucca F, Jenkins S, Merriman M, Wilson A, McKinney P, Bosi E, Joner G, Rønningen KS, Rønningen K, et al. Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11. Hum Mol Genet. 1997 Jul;6(7):1011–1016. [PubMed]
  • Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science. 1996 Sep 13;273(5281):1516–1517. [PubMed]
  • Schaid DJ. Relative-risk regression models using cases and their parents. Genet Epidemiol. 1995;12(6):813–818. [PubMed]
  • Schaid DJ, Li H. Genotype relative-risks and association tests for nuclear families with missing parental data. Genet Epidemiol. 1997;14(6):1113–1118. [PubMed]
  • Schaid DJ, Sommer SS. Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet. 1993 Nov;53(5):1114–1126. [PMC free article] [PubMed]
  • Self SG, Longton G, Kopecky KJ, Liang KY. On estimating HLA/disease association with application to a study of aplastic anemia. Biometrics. 1991 Mar;47(1):53–61. [PubMed]
  • Sham PC, Curtis D. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet. 1995 Jul;59(Pt 3):323–336. [PubMed]
  • Spielman RS, Ewens WJ. The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet. 1996 Nov;59(5):983–989. [PMC free article] [PubMed]
  • Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet. 1993 Mar;52(3):506–516. [PMC free article] [PubMed]
  • Waldman ID, Robinson BF, Feigon SA. Linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder: extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity. Genet Epidemiol. 1997;14(6):699–704. [PubMed]
  • Weinberg CR, Wilcox AJ, Lie RT. A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet. 1998 Apr;62(4):969–978. [PMC free article] [PubMed]
  • Wyszynski DF, Maestri N, McIntosh I, Smith EA, Lewanda AF, Garcia-Delgado C, Vinageras-Guarneros E, Wulfsberg E, Beaty TH. Evidence for an association between markers on chromosome 19q and non-syndromic cleft lip with or without cleft palate in two groups of multiplex families. Hum Genet. 1997 Jan;99(1):22–26. [PubMed]

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