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Br J Clin Pharmacol. Oct 1993; 36(4): 369–371.
PMCID: PMC1364693

The personality structure of 'normal' volunteers.


The personality structure of 65 volunteers for a Phase 1 drug trial was examined using the Eysenck Personality Questionnaire. It revealed a common pattern of high extroversion, low neuroticism and psychoticism. The reasons why the study might attract such people are examined and the structure compared with those that take drugs that might have 'strange or dangerous effects'. The likely forms of bias that this personality structure may bring to the trial are explored.

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Selected References

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  • LASAGNA L, VON FELSINGER JM. The volunteer subject in research. Science. 1954 Sep 3;120(3114):359–361. [PubMed]
  • Amori G, Lenox RH. Do volunteer subjects bias clinical trials? J Clin Psychopharmacol. 1989 Oct;9(5):321–327. [PubMed]
  • Barrett J. Psychiatric diagnoses (Research Diagnostic Criteria) in symptomatic volunteers. Arch Gen Psychiatry. 1981 Feb;38(2):153–157. [PubMed]
  • Eysenck HJ. Personality and sexual adjustment. Br J Psychiatry. 1971 Jun;118(547):593–608. [PubMed]
  • Ayd FJ, Jr, Calabresi P. Motivations and rewards for volunteering to be an experimental subject. Clin Pharmacol Ther. 1972 Sep-Oct;13(5):771–781. [PubMed]
  • Thase ME, Last CG, Hersen M, Bellack AS, Himmelhoch JM. Symptomatic volunteers in depression research: a closer look. Psychiatry Res. 1984 Jan;11(1):25–33. [PubMed]
  • ESECOVER H, MALITZ S, WILKENS B. Clinical profiles of paid normal subjects volunteering for hallucinogen drug studies. Am J Psychiatry. 1961 Apr;117:910–915. [PubMed]
  • POLLIN W, PERLIN S. Psychiatric evaluation of normal control volunteers. Am J Psychiatry. 1958 Aug;115(2):129–133. [PubMed]
  • Ludvigh EJ, 3rd, Happ D. Extraversion and preferred level of sensory stimulation. Br J Psychol. 1974 Aug;65(3):359–365. [PubMed]
  • Hill AB. Extraversion and variety-seeking in a monotonous task. Br J Psychol. 1975 Feb;66(1):9–13. [PubMed]
  • Gossop MR. A comparative study of oral and intravenous drug-dependent patients on three dimensions of personality. Int J Addict. 1978 Jan;13(1):135–142. [PubMed]
  • Beaubrun MH, Knight F. Psychiatric assessment of 30 chronic users of cannabis and 30 matched controls. Am J Psychiatry. 1973 Mar;130(3):309–311. [PubMed]

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