Logo of annsurgLink to Publisher's site
Ann Surg. Sep 1991; 214(3): 328–338.
PMCID: PMC1358657

The role of multimodality therapy in soft-tissue sarcoma.


Soft-tissue sarcomas are uncommon malignancies. The development during a period of 8 years, in one institution, of a prospective data base incorporating more than 1600 patients with these tumors is described. The most common sites for occurrence are the extremities, but they can occur in any of the soft tissues of the body. Liposarcoma and leiomyosarcoma are the most common histopathologic conditions identified. Prognostic factors for both recurrence and survival include site, histopathology, size, grade, and adequacy of resection. A prospective randomized trial of the use of adjuvant radiation by the brachytherapy technique in extremity lesions has shown a decrease in local recurrence, but no impact on survival. Eligible patients not randomized to the trial show no difference in local recurrence or survival, regardless of whether they received adjuvant radiation.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (960K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Kilman JW, Clatworthy HW, Jr, Newton WA, Jr, Grosfeld JL. Reasonable surgery for rhabdomyosarcoma: a study of 67 cases. Ann Surg. 1973 Sep;178(3):346–351. [PMC free article] [PubMed]
  • Malpas JS, Freeman JE, Paxton A, Smith JW, Stansfeld AG, Wood CB. Radiotherapy and adjuvant combination chemotherapy for childhood rhabdomyosarcoma. Br Med J. 1976 Jan 31;1(6004):247–249. [PMC free article] [PubMed]
  • Brennan MF, Hilaris B, Shiu MH, Lane J, Magill G, Friedrich C, Hajdu SI. Local recurrence in adult soft-tissue sarcoma. A randomized trial of brachytherapy. Arch Surg. 1987 Nov;122(11):1289–1293. [PubMed]
  • Collin CF, Friedrich C, Godbold J, Hajdu S, Brennan MF. Prognostic factors for local recurrence and survival in patients with localized extremity soft-tissue sarcoma. Semin Surg Oncol. 1988;4(1):30–37. [PubMed]
  • Ormsby MV, Hilaris BS, Nori D, Brennan MF. Wound complications of adjuvant radiation therapy in patients with soft-tissue sarcomas. Ann Surg. 1989 Jul;210(1):93–99. [PMC free article] [PubMed]
  • Arbeit JM, Hilaris BS, Brennan MF. Wound complications in the multimodality treatment of extremity and superficial truncal sarcomas. J Clin Oncol. 1987 Mar;5(3):480–488. [PubMed]
  • Collin C, Hadju SI, Godbold J, Shiu MH, Hilaris BI, Brennan MF. Localized, operable soft tissue sarcoma of the lower extremity. Arch Surg. 1986 Dec;121(12):1425–1433. [PubMed]
  • Collin C, Hajdu SI, Godbold J, Friedrich C, Brennan MF. Localized operable soft tissue sarcoma of the upper extremity. Presentation, management, and factors affecting local recurrence in 108 patients. Ann Surg. 1987 Apr;205(4):331–339. [PMC free article] [PubMed]
  • Collin C, Godbold J, Hajdu S, Brennan M. Localized extremity soft tissue sarcoma: an analysis of factors affecting survival. J Clin Oncol. 1987 Apr;5(4):601–612. [PubMed]
  • Chang HR, Gaynor J, Tan C, Hajdu SI, Brennan MF. Multifactorial analysis of survival in primary extremity liposarcoma. World J Surg. 1990 Sep-Oct;14(5):610–618. [PubMed]
  • Donohue JH, Collin C, Friedrich C, Godbold J, Hajdu SI, Brennan MF. Low-grade soft tissue sarcomas of the extremities. Analysis of risk factors for metastasis. Cancer. 1988 Jul 1;62(1):184–193. [PubMed]
  • Russell WO, Cohen J, Enzinger F, Hajdu SI, Heise H, Martin RG, Meissner W, Miller WT, Schmitz RL, Suit HD. A clinical and pathological staging system for soft tissue sarcomas. Cancer. 1977 Oct;40(4):1562–1570. [PubMed]
  • Devereux DF, Kent H, Brennan MF. Time dependent effects of adriamycin and x-ray therapy on wound healing in the rat. Cancer. 1980 Jun 1;45(11):2805–2810. [PubMed]
  • Cance WG, Brennan MF, Dudas ME, Huang CM, Cordon-Cardo C. Altered expression of the retinoblastoma gene product in human sarcomas. N Engl J Med. 1990 Nov 22;323(21):1457–1462. [PubMed]
  • Wunder JS, Czitrom AA, Kandel R, Andrulis IL. Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. J Natl Cancer Inst. 1991 Feb 6;83(3):194–200. [PubMed]
  • Fletcher JA, Kozakewich HP, Hoffer FA, Lage JM, Weidner N, Tepper R, Pinkus GS, Morton CC, Corson JM. Diagnostic relevance of clonal cytogenetic aberrations in malignant soft-tissue tumors. N Engl J Med. 1991 Feb 14;324(7):436–442. [PubMed]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...