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Ann Surg. May 1982; 195(5): 566–573.
PMCID: PMC1352559

Experimental gallstone pancreatitis. Pathogenesis and response to different treatment modalities.


Partial pancreatic duct obstruction due to gallstone migration has been suggested as an important step in the pathogenesis of gallstone, pancreatitis. Since gallstone migration often follows a meal, pancreatic secretory stimulation is also present. Utilizing the isolated perfused canine pancreas, an experimental model of gallstone pancreatitis was developed by partial obstruction of the main pancreatic duct and secretin stimulation (POSS). In control glands (n=6) perfused for a four-hour period, gross appearance remained normal, weight gain (8 g) was minimal, and mean amylase (875 Caraway units/dl) remained within normal limits. POSS glands (n=9) became markedly edematous during the perfusion period, with significant weight gain (47 g) and hyperamylasemia (7200 Caraway units/dl). Steroid-treated (n=6) and Trasylol-treated (n=6) POSS glands became edematous, and mean weight gain and hyperamylasemia were similar to those seen in untreated POSS glands. Glucagon-treated POSS glands (n=6) became edematous, but mean weight gain (24 g) was significantly decreased compared with that of untreated POSS glands. Mean amylase elevation was unchanged (8536 Caraway units/dl). POSS glands treated with albumin (n=6) remained normal in gross appearance, mean weight gain (12 g) was minimal and mean amylase (3120 Caraway units/dl) was significantly decreased compared to that of untreated POSS glands. The failure of Trasylol to ameliorate the injury response and the effectiveness of albumin were interpreted as evidence against enzyme extravasation and for capillary injury as the initial step in the pathogenesis of gallstone pancreatitis.

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Selected References

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  • Acosta JM, Ledesma CL. Gallstone migration as a cause of acute pancreatitis. N Engl J Med. 1974 Feb 28;290(9):484–487. [PubMed]
  • Broe PJ, Zinner MJ, Cameron JL. A clinical trial of cimetidine in acute pancreatitis. Surg Gynecol Obstet. 1982 Jan;154(1):13–16. [PubMed]
  • Cameron JL, Mehigan D, Zuidema GD. Evaluation of atropine in acute pancreatitis. Surg Gynecol Obstet. 1979 Feb;148(2):206–208. [PubMed]
  • Condon JR, Knight M, Day JL. Glucagon therapy in acute pancreatitis. Br J Surg. 1973 Jul;60(7):509–511. [PubMed]
  • Dürr HK, Maroske D, Zelder O, Bode JC. Glucagon therapy in acute pancreatitis. Report of a double-blind trial. Gut. 1978 Mar;19(3):175–179. [PMC free article] [PubMed]
  • Dyck WP, Rudick J, Hoexter B, Janowitz HD. Influence of glucagon on pancreatic exocrine secretion. Gastroenterology. 1969 Mar;56(3):531–537. [PubMed]
  • ELLIOTT DW. Treatment of acute pancreatitis with albumin and whole blood. AMA Arch Surg. 1957 Oct;75(4):573–580. [PubMed]
  • Gilsanz V, Oteyza CP, Rebollar JL. Glucagon vs anticholinergics in the treatment of acute pancreatitis. A double-blind controlled trial. Arch Intern Med. 1978 Apr;138(4):535–538. [PubMed]
  • Hermon-Taylor J. A technique for perfusion of the isolated canine pancreas. Responses to secretin and gastrin. Gastroenterology. 1968 Oct;55(4):488–501. [PubMed]
  • Imrie CW, Benjamin IS, Ferguson JC, McKay AJ, Mackenzie I, O'Neill J, Blumgart LH. A single-centre double-blind trial of Trasylol therapy in primary acute pancreatitis. Br J Surg. 1978 May;65(5):337–341. [PubMed]
  • Imrie CW, Whyte AS. A prospective study of acute pancreatitis. Br J Surg. 1975 Jun;62(6):490–494. [PubMed]
  • KAPLAN MH. ACTH and cortisone in gastroenterology. Am J Gastroenterol. 1957 Feb;27(2):163–179. [PubMed]
  • Kelly TR. Gallsonte pancreatitis. Arch Surg. 1974 Aug;109(2):294–297. [PubMed]
  • Kelly TR. Gallstone pancreatitis: pathophysiology. Surgery. 1976 Oct;80(4):488–492. [PubMed]
  • Kimura T, Zuidema GD, Cameron JL. Acute pancreatitis. Experimental evaluation of steroid, albumin and trasylol therapy. Am J Surg. 1980 Sep;140(3):403–408. [PubMed]
  • Kimura T, Zuidema GD, Cameron JL. Experimental pancreatitis: influence of secretory state of the pancreas. Surgery. 1980 Nov;88(5):661–666. [PubMed]
  • Knight MJ, Condon JR, Smith R. Possible use of glucagon in the treatment of pancreatitis. Br Med J. 1971 May 22;2(5759):440–442. [PMC free article] [PubMed]
  • Levant JA, Secrist DM, Resin H, Sturdevant RA, Guth PH. Nasogastric suction in the treatment of alcoholic pancreatitis. A controlled study. JAMA. 1974 Jul 1;229(1):51–52. [PubMed]
  • Nakashima Y, Howard JM. Drug-induced acute pancreatitis. Surg Gynecol Obstet. 1977 Jul;145(1):105–109. [PubMed]
  • Olazabal A, Fuller R. Failure of glucagon in the treatment of alcoholic pancreatitis. Gastroenterology. 1978 Mar;74(3):489–491. [PubMed]
  • Schapiro H, Ludewig RM. The effect of glucagon on the exocrine pancreas. A review. Am J Gastroenterol. 1978 Sep;70(3):274–281. [PubMed]
  • Schiller WR, Duprez A, Iams WB, Suwa M, Anderson MC. Experimental pancreatitis. Treatment by colloid replacement and adrenocorticosteroid therapy combined with thoracic duct drainage. Arch Surg. 1969 Jun;98(6):698–702. [PubMed]
  • Trapnell JE. The natural history and prognosis of acute pancreatitis. Ann R Coll Surg Engl. 1966 May;38(5):265–287. [PMC free article] [PubMed]
  • Trapnell JE, Rigby CC, Talbot CH, Duncan EH. A controlled trial of Trasylol in the treatment of acute pancreatitis. Br J Surg. 1974 Mar;61(3):177–182. [PubMed]

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