• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jphysiolThe Journal of Physiology SiteMembershipSubmissionJ Physiol
J Physiol. Oct 1975; 252(1): 137–158.
PMCID: PMC1348472

Readjustment of retinotectal projection following reimplantation of a rotated or inverted tectal tissue in adult goldfish.

Abstract

1. The pattern of visual projection from the retina on to the optic tectum following reimplantation of a piece of the tectal tissue was studied with neurophysiological mapping methods in adult goldfish. 2. When a rectangular piece of the tectum was dissected, lifted free, and then reimplanted to the same tectum after rotation by 180 degrees around the dorsoventral axis, the re-established visual projection later showed a complete reversal of retinotopic order within the reimplanted area with reference to the normal projection on to the intact surrounding area of the same tectum. The localized reversal was observed as early as 65 days, and also as late as 721 days after the 180 degree rotated reimplantation. 3. If a square piece of the tectal tissue was reimplanted after rotation by 90 degrees anticlockwise around the dorsoventral axis, the restored visual projection later showed a corresponding localized 90 degrees rotation within the reimplanted ares. 4. When the entire laminar structure of a dissected tectal tissue was inverted, and the reimplanted upside-down along the same rostrocaudal axis of the tectum, the restored visual projection on to the inverted tectal reimplant was found to be organized in a reverse retinotopic order along only the mediolateral axis within the reimplanted area. The restored visual projection retained a correct retinotopic order along the rostrocaudal axis. The same trends were also observed after regeneration of the optic fibres following section of the contralateral optic nerve. 5. If the inverted tectal tissue was reimplanted along the same mediolateral axis of the tectum, the re-established visual projection showed a localized reversal of retinotopic order along only the rostrocaudal axis within the reimplanted area. Sectioning the contralateral optic nerve made no difference to the result. 6. These results suggest that a piece of adult tectal tissue retains its original topographic polarity regardless of the orientation of reimplantation after either a rotation or an inversion. Furthermore the retention is not a short-lived transitory phenomenon. It persisted as long as the reimplanted tissue survived. 7. Histological examination of the operated tecta revealed that the reimplanted tectal tissues underwent a severe derangement in their laminar structures. It was impossible to identify the main target zone of retinotectal projection (the stratum fibrosum et griseum superficiale) or the central cellular layer (the stratum griseum centrale) in the reimplants. The prominent feature of the deranged tectal tissue was irregular vortices of tangled fibre bundles. Sparse tectal neurones of bipolar and granular types were irregularly scattered in the deranged structure of the reimplant. 8. Thus, the retention of original topographic polarity did not require an integrity of the cytoarchitectonic structure of the reimplanted tectal tissue.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (3.9M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • ATTARDI DG, SPERRY RW. Preferential selection of central pathways by regenerating optic fibers. Exp Neurol. 1963 Jan;7:46–64. [PubMed]
  • Hunt RK, Jacobson M. Development and stability of postional information in Xenopus retinal ganglion cells. Proc Natl Acad Sci U S A. 1972 Apr;69(4):780–783. [PMC free article] [PubMed]
  • Hunt RK, Jacobson M. Specification of positional information in retinal ganglion cells of Xenopus: assays for analysis of the unspecified state. Proc Natl Acad Sci U S A. 1973 Feb;70(2):507–511. [PMC free article] [PubMed]
  • Hunt RK, Jacobson M. Development of neuronal locus specificity in Xenopus retinal ganglion cells after surgical eye transection after fusion of whole eyes. Dev Biol. 1974 Sep;40(1):1–15. [PubMed]
  • Jacobson M. Cessation of DNA synthesis in retinal ganglion cells correlated with the time of specification of their central conections. Dev Biol. 1968 Feb;17(2):219–232. [PubMed]
  • Levine R, Jacobson M. Deployment of optic nerve fibers is determined by positional markers in the frog's tectum. Exp Neurol. 1974 Jun;43(3):527–538. [PubMed]
  • Sharma SC, Gaze RM. The retinotopic organization of visual responses from tectal reimplants in adult goldfish. Arch Ital Biol. 1971 Dec;109(4):357–366. [PubMed]
  • Sharma SC, Hollyfield JG. Specification of retinal central connections in Rana pipiens before the appearance of the first post-mitotic ganglion cells. J Comp Neurol. 1974 Jun 15;155(4):395–407. [PubMed]
  • SPERRY RW. Regulative factors in the orderly growth of neural circuits. Growth. 1951;(Suppl 10):63–87. [PubMed]
  • Yoon M. Reorganization of retinotectal projection following surgical operations on the optic tectum in goldfish. Exp Neurol. 1971 Nov;33(2):395–411. [PubMed]
  • Yoon M. Reversibility of the reorganization of retinotectal projection in goldfish. Exp Neurol. 1972 Jun;35(3):565–577. [PubMed]
  • Yoon MG. Retention of the original topographic polarity by the 180 degrees rotated tectal reimplant in young adult goldfish. J Physiol. 1973 Sep;233(3):575–588. [PMC free article] [PubMed]
  • Yoon MG. Effects of post-operative visual environments on reorganization of retinotectal projection in goldfish. J Physiol. 1975 Apr;246(3):673–694. [PMC free article] [PubMed]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

Formats:

Cited by other articles in PMC

See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...