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Logo of jphysiolThe Journal of Physiology SiteMembershipSubmissionJ Physiol
J Physiol. Oct 1975; 251(2): 549–559.
PMCID: PMC1348442

Intracellular chloride activity in frog heart.

Abstract

1. Chloride liquid ion exchanger micro-electrodes have been used to measure intracellular chloride activity (aiCl) in isolated pieces of frog sinus venosus, atrium and ventricle. 2. aiCl was found to be 35-0 +/- 3-2, 17-3 +/- 0-8 and 17-6 +/- 0-8 mM in sinus venosus, atrium and ventricle, respectively. 3. In atrium and ventricle aiCl is independent of whether the tissue is beating or non-beating. 4. In non-beating ventricle aiCl changes rapidly and reversibly when aOCl is reduced by replacing chloride with glucuronate. 5. ECl calculated from the measured aiCl has been compared with ECl calculated from the constant field equation assuming either constant chloride conductance or constant chloride permeability. 6. It is suggested that chloride is actively transported into the cells in all three kinds of frog heart tissue.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • DEMELLO WC. ROLE OF CHLORIDE IONS IN CARDIAC ACTION AND PACEMAKER POTENTIALS. Am J Physiol. 1963 Sep;205:567–575. [PubMed]
  • HODGKIN AL, KATZ B. The effect of sodium ions on the electrical activity of giant axon of the squid. J Physiol. 1949 Mar 1;108(1):37–77. [PMC free article] [PubMed]
  • HUTTER OF, NOBLE D. Anion conductance of cardiac muscle. J Physiol. 1961 Jul;157:335–350. [PMC free article] [PubMed]
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  • Neild TO, Thomas RC. New design for a chloride-sensitive micro-electrode. J Physiol. 1973 May;231(1):7P–8P. [PubMed]
  • Walker JL, Ladle RO. Frog heart intracellular potassium activities measured with potassium microelectrodes. Am J Physiol. 1973 Jul;225(1):263–267. [PubMed]

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