• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of biophysjLink to Publisher's site
Biophys J. Jul 1983; 43(1): 121–125.
PMCID: PMC1329275

The effect of receptor clustering on diffusion-limited forward rate constants.

Abstract

The effect of receptor clustering on the diffusion-limited forward rate constant (k+) is studied theoretically by modeling cell surface receptors by hemispheres distributed on a plane. We give both exact results and bounds. The exact results are obtained using an electrostatic analogue and applying the method of the images. Accurate upper bounds on k+ are found from a variational principle.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (664K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Berg HC, Purcell EM. Physics of chemoreception. Biophys J. 1977 Nov;20(2):193–219. [PMC free article] [PubMed]
  • DeLisi C, Wiegel FW. Effect of nonspecific forces and finite receptor number on rate constants of ligand--cell bound-receptor interactions. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5569–5572. [PMC free article] [PubMed]
  • Czech MP, Massague J. Subunit structure and dynamics of the insulin receptor. Fed Proc. 1982 Sep;41(11):2719–2723. [PubMed]
  • Anderson RG, Brown MS, Goldstein JL. Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts. Cell. 1977 Mar;10(3):351–364. [PubMed]
  • Goldstein JL, Anderson RG, Brown MS. Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature. 1979 Jun 21;279(5715):679–685. [PubMed]
  • Pitas RE, Innerarity TL, Arnold KS, Mahley RW. Rate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: evidence for multiple receptor binding of apo-E HDLc. Proc Natl Acad Sci U S A. 1979 May;76(5):2311–2315. [PMC free article] [PubMed]
  • Jarett L, Schweitzer JB, Smith RM. Insulin receptors: differences in structural organization on adipocyte and liver plasma membranes. Science. 1980 Dec 5;210(4474):1127–1128. [PubMed]
  • DeLisi C. The biophysics of ligand-receptor interactions. Q Rev Biophys. 1980 May;13(2):201–230. [PubMed]
  • Shoup D, Szabo A. Role of diffusion in ligand binding to macromolecules and cell-bound receptors. Biophys J. 1982 Oct;40(1):33–39. [PMC free article] [PubMed]

Articles from Biophysical Journal are provided here courtesy of The Biophysical Society

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...