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Journal List > Can J Comp Med > v.35(1); Jan 1971

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Can J Comp Med. 1971 January; 35(1): 67–70.
PMCID: PMC1319543
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Congenital Hemolytic Anemia in the Basenji Dog Due to Erythrocyte Pyruvate Kinase Deficiency
G. P. Searcy and J. B. Tasker
New York State Veterinary College, Cornell University, Ithaca, New York.
D. R. Miller
University of Rochester, School of Medicine and Dentistry, Rochester, New York.
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Abstract
Congenital hemolytic anemia in the Basenji dog resembles pyruvate kinase (PK) deficiency in man as it is characterized by an abbreviated erythrocyte life span, an intense reticulocytosis, type II autohemolysis and splenomegaly. Glucose utilization and lactate production were inadequate with respect to the immature cell population. Analysis of enzymes involved in erythrocyte glycolysis revealed a deficiency of pyruvate kinase.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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