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Br J Gen Pract. Nov 1999; 49(448): 919–922.
PMCID: PMC1313568

Conducting randomized trials in general practice: methodological and practical issues.


The evaluation of the outcome of health services technologies is a requirement for their efficient provision in clinical practice. The most reliable evidence for treatment efficacy comes from randomized trials. Randomized trials in general practice pose particular methodological and practical difficulties. In this paper, we discuss how best to plan and manage a clinical trial in this setting. We base our discussion on our experience of conducting randomized trials to evaluate the effectiveness of brief psychotherapy in general practice.

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Selected References

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  • Silagy CA, Jewell D. Review of 39 years of randomized controlled trials in the British Journal of General Practice. Br J Gen Pract. 1994 Aug;44(385):359–363. [PMC free article] [PubMed]
  • Mattson ME, Curb JD, McArdle R. Participation in a clinical trial: the patients' point of view. Control Clin Trials. 1985 Jun;6(2):156–167. [PubMed]
  • Llewellyn-Thomas HA, McGreal MJ, Thiel EC, Fine S, Erlichman C. Patients' willingness to enter clinical trials: measuring the association with perceived benefit and preference for decision participation. Soc Sci Med. 1991;32(1):35–42. [PubMed]
  • Brewin CR, Bradley C. Patient preferences and randomised clinical trials. BMJ. 1989 Jul 29;299(6694):313–315. [PMC free article] [PubMed]
  • McKay JR, Alterman AI, McLellan AT, Snider EC, O'Brien CP. Effect of random versus nonrandom assignment in a comparison of inpatient and day hospital rehabilitation for male alcoholics. J Consult Clin Psychol. 1995 Feb;63(1):70–78. [PubMed]
  • Silverman WA, Altman DG. Patients' preferences and randomised trials. Lancet. 1996 Jan 20;347(8995):171–174. [PubMed]
  • Torgerson DJ, Sibbald B. Understanding controlled trials. What is a patient preference trial? BMJ. 1998 Jan 31;316(7128):360–360. [PMC free article] [PubMed]
  • Scott J, Moon CA, Blacker CV, Thomas JM. A. I. F. Scott & C. P. L. Freeman's "Edinburgh Primary Care Depression Study. Br J Psychiatry. 1994 Mar;164(3):410–415. [PubMed]
  • King M, Broster G, Lloyd M, Horder J. Controlled trials in the evaluation of counselling in general practice. Br J Gen Pract. 1994 May;44(382):229–232. [PMC free article] [PubMed]
  • Fairhurst K, Dowrick C. Problems with recruitment in a randomized controlled trial of counselling in general practice: causes and implications. J Health Serv Res Policy. 1996 Apr;1(2):77–80. [PubMed]
  • Hancock BW, Aitken M, Radstone C, Hudson GV. Why don't cancer patients get entered into clinical trials? Experience of the Sheffield Lymphoma Group's collaboration in British National Lymphoma Investigation studies. BMJ. 1997 Jan 4;314(7073):36–37. [PMC free article] [PubMed]
  • Korn EL, Baumrind S. Randomised clinical trials with clinician-preferred treatment. Lancet. 1991 Jan 19;337(8734):149–152. [PubMed]
  • Friedli K, King MB, Lloyd M, Horder J. Randomised controlled assessment of non-directive psychotherapy versus routine general-practitioner care. Lancet. 1997 Dec 6;350(9092):1662–1665. [PubMed]
  • Foy R, Parry J, McAvoy B. Clinical trials in primary care: targeted payments for trials might help improve recruitment and quality. BMJ. 1998 Oct 31;317(7167):1168–1169. [PMC free article] [PubMed]
  • Pringle M, Churchill R. Randomised controlled trials in general practice. BMJ. 1995 Nov 25;311(7017):1382–1383. [PMC free article] [PubMed]
  • Tognoni G, Alli C, Avanzini F, Bettelli G, Colombo F, Corso R, Marchioli R, Zussino A. Randomised clinical trials in general practice: lessons from a failure. BMJ. 1991 Oct 19;303(6808):969–971. [PMC free article] [PubMed]

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