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The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage
Cemalettin Bekpen, Julia P Hunn, Christoph Rohde, Iana Parvanova, Libby Guethlein, Diane M Dunn, Eva Glowalla, Maria Leptin, Jonathan C Howard
Genome Biol. 2005; 6(11): R92. Published online 2005 October 31. doi: 10.1186/gb-2005-6-11-r92
PMCID:
PMC1297648
Abstract Full Text PDF–1.7M Supplementary Material

Is Cited by the Following 45 Articles in this Archive:

IRGM Is a Common Target of RNA Viruses that Subvert the Autophagy Network
Isabel Pombo Grégoire, Clémence Richetta, Laurène Meyniel-Schicklin, Sophie Borel, Fabrine Pradezynski, Olivier Diaz, Alexandre Deloire, Olga Azocar, Joël Baguet, Marc Le Breton, Philippe E. Mangeot, Vincent Navratil, Pierre-Emmanuel Joubert, Monique Flacher, Pierre-Olivier Vidalain, Patrice André, Vincent Lotteau, Martine Biard-Piechaczyk, Chantal Rabourdin-Combe, Mathias Faure
PLoS Pathog. 2011 December; 7(12): e1002422. Published online 2011 December 8. doi: 10.1371/journal.ppat.1002422
PMCID:
PMC3234227
Abstract Full Text PDF–1.9M Supplementary Material
Determinants of GBP Recruitment to Toxoplasma gondii Vacuoles and the Parasitic Factors That Control It
Sebastian Virreira Winter, Wendy Niedelman, Kirk D. Jensen, Emily E. Rosowski, Lindsay Julien, Eric Spooner, Kacey Caradonna, Barbara A. Burleigh, Jeroen P. J. Saeij, Hidde L. Ploegh, Eva-Maria Frickel
PLoS One. 2011; 6(9): e24434. Published online 2011 September 8. doi: 10.1371/journal.pone.0024434
PMCID:
PMC3169597
Abstract Full Text PDF–2.8M Supplementary Material
Viruses, Autophagy Genes, and Crohn’s Disease
Vanessa M. Hubbard, Ken Cadwell
Viruses. 2011 July; 3(7): 1281–1311. Published online 2011 July 21. doi: 10.3390/v3071281
PMCID:
PMC3185787
Abstract Full Text PDF–955K
Immunity-related GTPase M (IRGM) Proteins Influence the Localization of Guanylate-binding Protein 2 (GBP2) by Modulating Macroautophagy
Maria K. Traver, Stanley C. Henry, Viviana Cantillana, Tim Oliver, Julia P. Hunn, Jonathan C. Howard, Sandra Beer, Klaus Pfeffer, Jörn Coers, Gregory A. Taylor
J Biol Chem. 2011 September 2; 286(35): 30471–30480. Published online 2011 July 12. doi: 10.1074/jbc.M111.251967
PMCID:
PMC3162407
Free in PMC on 2012/09/02
The IFN-γ-Inducible GTPase, Irga6, Protects Mice against Toxoplasma gondii but Not against Plasmodium berghei and Some Other Intracellular Pathogens
Oliver Liesenfeld, Iana Parvanova, Jens Zerrahn, Seong-Ji Han, Frederik Heinrich, Melba Muñoz, Frank Kaiser, Toni Aebischer, Thorsten Buch, Ari Waisman, Gaby Reichmann, Olaf Utermöhlen, Esther von Stebut, Friederike D. von Loewenich, Christian Bogdan, Sabine Specht, Michael Saeftel, Achim Hoerauf, Maria M. Mota, Stephanie Könen-Waisman, Stefan H. E. Kaufmann, Jonathan C. Howard
PLoS One. 2011; 6(6): e20568. Published online 2011 June 17. doi: 10.1371/journal.pone.0020568
PMCID:
PMC3117789
Abstract Full Text PDF–501K Supplementary Material
Autophagy in Immunity and Cell-Autonomous Defense Against Intracellular Microbes
Vojo Deretic
Immunol Rev. Author manuscript; available in PMC 2012 March 1.
Published in final edited form as: Immunol Rev. 2011 March; 240(1): 92–104. doi: 10.1111/j.1600-065X.2010.00995.x
PMCID:
PMC3057454
Abstract Full Text PDF–1.4M
The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii
Nikolaus Pawlowski, Aliaksandr Khaminets, Julia P Hunn, Natasa Papic, Andreas Schmidt, Revathy C Uthaiah, Rita Lange, Gabriela Vopper, Sascha Martens, Eva Wolf, Jonathan C Howard
BMC Biol. 2011; 9: 7. Published online 2011 January 28. doi: 10.1186/1741-7007-9-7
PMCID:
PMC3042988
Abstract Full Text PDF–3.4M Supplementary Material
The Guanylate-Binding Proteins: Emerging Insights into the Biochemical Properties and Functions of This Family of Large Interferon-Induced Guanosine Triphosphatase
Deborah J. Vestal, Jonathan A. Jeyaratnam
J Interferon Cytokine Res. 2011 January; 31(1): 89–97. doi: 10.1089/jir.2010.0102
PMCID:
PMC3021356
Abstract Full Text PDF–211K
The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels
Jose-Andres C. Portillo, Genevieve Okenka, Erin Reed, Angela Subauste, Jennifer Van Grol, Katrin Gentil, Masaaki Komatsu, Keiji Tanaka, Gary Landreth, Beth Levine, Carlos S. Subauste
PLoS One. 2010; 5(12): e14472. Published online 2010 December 31. doi: 10.1371/journal.pone.0014472
PMCID:
PMC3013095
Abstract Full Text PDF–3.8M Supplementary Material
Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii
Tobias Steinfeldt, Stephanie Könen-Waisman, Lan Tong, Nikolaus Pawlowski, Tobias Lamkemeyer, L. David Sibley, Julia P. Hunn, Jonathan C. Howard
PLoS Biol. 2010 December; 8(12): e1000576. Published online 2010 December 21. doi: 10.1371/journal.pbio.1000576
PMCID:
PMC3006384
Abstract Full Text PDF–955K Supplementary Material
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii secreted kinase promotes macrophage survival and virulence
Sarah J. Fentress, Michael S. Behnke, Ildiko R. Dunay, Mona Mashayekhi, Leah M. Rommereim, Barbara A. Fox, David J. Bzik, Gregory A. Taylor, Benjamin E. Turk, Cheryl F. Lichti, R. Reid Townsend, Wei Qiu, Raymond Hui, Wandy L. Beatty, L. David Sibley
Cell Host Microbe. Author manuscript; available in PMC 2011 December 16.
Published in final edited form as: Cell Host Microbe. 2010 December 16; 8(6): 484–495. doi: 10.1016/j.chom.2010.11.005
PMCID:
PMC3013631
Abstract Full Text PDF–1.4M Supplementary Material
Human IRGM Regulates Autophagy and Its Cell-Autonomous Immunity Functions Through Mitochondria
Sudha B. Singh, Wojciech Ornatowski, Isabelle Vergne, John Naylor, Monica Delgado, Esteban Roberts, Marisa Ponpuak, Sharon Master, Manohar Pilli, Eileen White, Masaaki Komatsu, Vojo Deretic
Nat Cell Biol. Author manuscript; available in PMC 2011 June 1.
Published in final edited form as: Nat Cell Biol. 2010 December; 12(12): 1154–1165. Published online 2010 November 21. doi: 10.1038/ncb2119
PMCID:
PMC2996476
Abstract Full Text PDF–2.0M Supplementary Material
Role of autophagy in the host response to microbial infection and potential for therapy
Mario Fabri, Susan E. Realegeno, Eun-Kyeong Jo, Robert L. Modlin
Curr Opin Immunol. Author manuscript; available in PMC 2012 February 1.
Published in final edited form as: Curr Opin Immunol. 2011 February; 23(1): 65–70. Published online 2010 November 9. doi: 10.1016/j.coi.2010.10.010
PMCID:
PMC3042547
Abstract Full Text PDF–70K
Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2)
David Schwefel, Chris Fröhlich, Jenny Eichhorst, Burkhard Wiesner, Joachim Behlke, L. Aravind, Oliver Daumke
Proc Natl Acad Sci U S A. 2010 November 23; 107(47): 20299–20304. Published online 2010 November 8. doi: 10.1073/pnas.1010322107
PMCID:
PMC2996681
Abstract Full Text PDF–1.7M Supplementary Material
The Interferon-γ–induced Murine Guanylate-Binding Protein-2 Inhibits Rac Activation during Cell Spreading on Fibronectin and after Platelet-derived Growth Factor Treatment: Role for Phosphatidylinositol 3-Kinase
Angela F. Messmer-Blust, Sujata Balasubramanian, Victoria Y. Gorbacheva, Jonathan A. Jeyaratnam, Deborah J. Vestal
Mol Biol Cell. 2010 July 15; 21(14): 2514–2528. doi: 10.1091/mbc.E09-04-0344
PMCID:
PMC2903678
Abstract Full Text PDF–2.6M Supplementary Material
The Mouse Resistance Protein Irgm1 (LRG-47): A Regulator or an Effector of Pathogen Defense?
Julia P. Hunn, Jonathan C. Howard
PLoS Pathog. 2010 July; 6(7): e1001008. Published online 2010 July 15. doi: 10.1371/journal.ppat.1001008
PMCID:
PMC2904798
Full Text PDF–245K
Monocytes Mediate Mucosal Immunity to Toxoplasma gondii
Ildiko R. Dunay, L. David Sibley
Curr Opin Immunol. Author manuscript; available in PMC 2011 August 1.
Published in final edited form as: Curr Opin Immunol. 2010 August; 22(4): 461–466. Published online 2010 May 27. doi: 10.1016/j.coi.2010.04.008
PMCID:
PMC2922417
Abstract Full Text PDF–895K
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole
Aliaksandr Khaminets, Julia P Hunn, Stephanie Könen-Waisman, Yang O Zhao, Daniela Preukschat, Jörn Coers, Jon P Boyle, Yi-Ching Ong, John C Boothroyd, Gabriela Reichmann, Jonathan C Howard
Cell Microbiol. 2010 July; 12(7): 939–961. Published online 2010 March 4. doi: 10.1111/j.1462-5822.2010.01443.x
PMCID:
PMC2901525
Abstract Full Text PDF–1.1M Supplementary Material
Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease
Natalie J. Prescott, Katherine M. Dominy, Michiaki Kubo, Cathryn M. Lewis, Sheila A. Fisher, Richard Redon, Ni Huang, Barbara E. Stranger, Katarzyna Blaszczyk, Barry Hudspith, Gareth Parkes, Naoya Hosono, Keiko Yamazaki, Clive M. Onnie, Alastair Forbes, Emmanouil T. Dermitzakis, Yusuke Nakamura, John C. Mansfield, Jeremy Sanderson, Matthew E. Hurles, Roland G. Roberts, Christopher G. Mathew
Hum Mol Genet. 2010 May 1; 19(9): 1828–1839. Published online 2010 January 27. doi: 10.1093/hmg/ddq041
PMCID:
PMC2850616
Abstract Full Text PDF–287K Supplementary Material
Localisation and Mislocalisation of the Interferon-Inducible Immunity-Related GTPase, Irgm1 (LRG-47) in Mouse Cells
Yang O. Zhao, Stephanie Könen-Waisman, Gregory A. Taylor, Sascha Martens, Jonathan C. Howard
PLoS One. 2010; 5(1): e8648. Published online 2010 January 13. doi: 10.1371/journal.pone.0008648
PMCID:
PMC2799677
Abstract Full Text PDF–4.4M Supplementary Material
Regulation of macrophage motility by Irgm1
Stanley C. Henry, Maria Traver, Xiaojou Daniell, Maanasa Indaram, Tim Oliver, Gregory A. Taylor
J Leukoc Biol. 2010 February; 87(2): 333–343. Published online 2009 November 17. doi: 10.1189/jlb.0509299
PMCID:
PMC2812558
Abstract Full Text Supplementary Material
Autophagy Gene Variant IRGM −261T Contributes to Protection from Tuberculosis Caused by Mycobacterium tuberculosis but Not by M. africanum Strains
Christopher D. Intemann, Thorsten Thye, Stefan Niemann, Edmund N. L. Browne, Margaret Amanua Chinbuah, Anthony Enimil, John Gyapong, Ivy Osei, Ellis Owusu-Dabo, Susanne Helm, Sabine Rüsch-Gerdes, Rolf D. Horstmann, Christian G. Meyer
PLoS Pathog. 2009 September; 5(9): e1000577. Published online 2009 September 11. doi: 10.1371/journal.ppat.1000577
PMCID:
PMC2735778
Abstract Full Text PDF–434K
A Dedicated Promoter Drives Constitutive Expression of the Cell-Autonomous Immune Resistance GTPase, Irga6 (IIGP1) in Mouse Liver
Jia Zeng, Iana Angelova Parvanova, Jonathan C. Howard
PLoS One. 2009; 4(8): e6787. Published online 2009 August 26. doi: 10.1371/journal.pone.0006787
PMCID:
PMC2848866
Abstract Full Text PDF–781K Supplementary Material
Human Guanylate Binding Proteins Potentiate the Anti-Chlamydia Effects of Interferon-γ
Illya Tietzel, Christelle El-Haibi, Rey A. Carabeo
PLoS One. 2009; 4(8): e6499. Published online 2009 August 4. doi: 10.1371/journal.pone.0006499
PMCID:
PMC2714978
Abstract Full Text PDF–624K Supplementary Material
Phagosomal membrane targeting of Irgm1 via PtdIns(3,4)P2 and PtdIns(3,4,5)P3 promotes mycobacterial immunity
Sangeeta Tiwari, Han-Pil Choi, Takeshi Matsuzawa, Marc Pypaert, John D. MacMicking
Nat Immunol. Author manuscript; available in PMC 2010 February 1.
Published in final edited form as: Nat Immunol. 2009 August; 10(8): 907–917. doi: 10.1038/ni.1759
PMCID:
PMC2715447
Abstract Full Text PDF–3.8M Supplementary Material
CD40 AND THE IMUNE RESPONSE TO PARASITIC INFECTIONS
Carlos S. Subauste
Semin Immunol. Author manuscript; available in PMC 2010 October 1.
Published in final edited form as: Semin Immunol. 2009 October; 21(5): 273–282. Published online 2009 July 18. doi: 10.1016/j.smim.2009.06.003
PMCID:
PMC2758065
Abstract Full Text PDF–608K
Modeling Infectious Disease in Mice: Co-Adaptation and the Role of Host-Specific IFNγ Responses
Jörn Coers, Michael N. Starnbach, Jonathan C. Howard
PLoS Pathog. 2009 May; 5(5): e1000333. Published online 2009 May 29. doi: 10.1371/journal.ppat.1000333
PMCID:
PMC2682201
Full Text PDF–142K
Virulent Toxoplasma gondii Evade Immunity-Related GTPase (IRG)-Mediated Parasite Vacuole Disruption Within Primed Macrophages
Yanlin Zhao, David J. P. Ferguson, Douglas C. Wilson, Jonathan C. Howard, L. David Sibley, George S. Yap
J Immunol. Author manuscript; available in PMC 2010 April 2.
Published in final edited form as: J Immunol. 2009 March 15; 182(6): 3775–3781. doi: 10.4049/jimmunol.0804190
PMCID:
PMC2848815
Abstract Full Text PDF–997K
Death and Resurrection of the Human IRGM Gene
Cemalettin Bekpen, Tomas Marques-Bonet, Can Alkan, Francesca Antonacci, Maria Bruna Leogrande, Mario Ventura, Jeffrey M. Kidd, Priscillia Siswara, Jonathan C. Howard, Evan E. Eichler
PLoS Genet. 2009 March; 5(3): e1000403. Published online 2009 March 6. doi: 10.1371/journal.pgen.1000403
PMCID:
PMC2644816
Abstract Full Text PDF–1.1M Supplementary Material
Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death
Yang O. Zhao, Aliaksandr Khaminets, Julia P. Hunn, Jonathan C. Howard
PLoS Pathog. 2009 February; 5(2): e1000288. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000288
PMCID:
PMC2629126
Abstract Full Text PDF–3.7M Supplementary Material
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