• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jphysiolThe Journal of Physiology SiteMembershipSubmissionJ Physiol
J Physiol. Aug 1980; 305: 357–376.
PMCID: PMC1282978

Cerebral blood flow and oxidative metabolism during hypoxia and asphyxia in the new-born calf and lamb.

Abstract

1. The effects of hypoxia and asphyxia on cerebral blood flow and oxidative metabolism have been investigated in the calf and lamb under sodium pentobarbitone anaesthesia. 2. Cerebral blood flow was determined using a hydrogen clearance technique, and cerebral metabolism quantified by the simultaneous measurement of arteriocerebral venous concentration differences for oxygen, glucose and lactate. Continuous measurements were made of arterial and cerebral venous PO2 in vivo. 3. Both cerebral blood flow and oxygen consumption were less in animals anaesthetized with sodium pentobarbitone than in conscious animals. 4. In the calf, recovery from transient episodes of severe hypoxia and asphyxia was associated with a rapid recovery and overshoot of cerebral venous PO2. Evidence was obtained that rapid changes in blood pressure during severe asphyxia were associated with pressure-passive cerebral blood flow. Prolonged hypoxia (Pa,O2:21 +/- 2 mmHg) with normocapnia was associated with an increase in cerebral blood flow, fall in cerebral oxygen consumption, and no change in the glucose-oxygen index. 5. In the lamb, prolonged asphyxia (Pa,O2:30 +/- 1 mmHg; Pa,CO2:56 +/- 2 mmHg) was associated with an increase in cerebral blood flow. Cerebral glucose uptake did not change, but cerebral oxygen consumption was markedly depressed, and the glucose-oxygen index increased. 6. In the lamb during normoxia, there was a linear correlation between cerebral blood flow and arterial PCO2 in the range 10-95 mmHg (r = 0.92; P < 0.001), with a slope of 1.74 ml. 100g-1 min-1 . mmHg Pa,CO2-1 . Hypoxia did not significantly increase the fall in cerebral vascular resistance associated with a rise in Pa,CO2 from 34 to 56 mmHg.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.9M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bicher HI, Bruley D, Knisely MH, Reneau DD. Effect of microcirculation changes on brain tissue oxygenation. J Physiol. 1971 Sep;217(3):689–707. [PMC free article] [PubMed]
  • Cohen PJ, Alexander SC, Smith TC, Reivich M, Wollman H. Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man. J Appl Physiol. 1967 Aug;23(2):183–189. [PubMed]
  • Jones MD, Jr, Burd LI, Makowski EL, Meschia G, Battaglia FC. Cerebral metabolism in sheep: a comparative study of the adult, the lamb, and the fetus. Am J Physiol. 1975 Jul;229(1):235–239. [PubMed]
  • Fieschi C, Bozzao L, Agnoli A. Regional clearance of hydrogen as a measure of cerebral blood flow. Acta Neurol Scand Suppl. 1965;14:46–52. [PubMed]
  • Gardiner RM. The effects of hypoglycaemia on cerebral blood flow and metabolism in the new-born calf. J Physiol. 1980 Jan;298:37–51. [PMC free article] [PubMed]
  • Gardiner RM. The effect of feeding on cerebral blood flow and oxygen consumption in the new-born calf. J Physiol. 1980 Apr;301:429–438. [PMC free article] [PubMed]
  • Häggendal E, Johansson B. Effects of arterial carbon dioxide tension and oxygen saturation on cerebral blood flow autoregulation in dogs. Acta Physiol Scand Suppl. 1965;258:27–53. [PubMed]
  • HARPER AM, BELL RA. THE EFFECT OF METABOLIC ACIDOSIS AND ALKALOSIS ON THE BLOOD FLOW THROUGH THE CEREBRAL CORTEX. J Neurol Neurosurg Psychiatry. 1963 Aug;26:341–344. [PMC free article] [PubMed]
  • James IM, Millar RA, Purves MJ. Observations on the extrinsic neural control of cerebral blood flow in the baboon. Circ Res. 1969 Jul;25(1):77–93. [PubMed]
  • Jansen CA, Krane EJ, Thomas AL, Beck NF, Lowe KC, Joyce P, Parr M, Nathanielsz PW. Continuous variability of fetal PO2 in the chronically catheterized fetal sheep. Am J Obstet Gynecol. 1979 Aug 1;134(7):776–783. [PubMed]
  • Jóhannsson H, Siesjö BK. Cerebral blood flow and oxygen consumption in the rat in hypoxic hypoxia. Acta Physiol Scand. 1975 Feb;93(2):269–276. [PubMed]
  • Kjellmer I, Karlsson K, Olsson T, Rosén KG. Cerebral reactions during intrauterine asphyxia in the sheep. I. Circulation and oxygen consumption in the fetal brain. Pediatr Res. 1974 Jan;8(1):50–57. [PubMed]
  • LINDEN RJ, LEDSOME JR, NORMAN J. SIMPLE METHODS FOR THE DETERMINATION OF THE CONCENTRATIONS OF CARBON DIOXIDE AND OXYGEN IN BLOOD. Br J Anaesth. 1965 Feb;37:77–88. [PubMed]
  • Lou HC, Lassen NA, Tweed WA, Johnson G, Jones M, Palahniuk RJ. Pressure passive cerebral blood flow and breakdown of the blood-brain barrier in experimental fetal asphyxia. Acta Paediatr Scand. 1979 Jan;68(1):57–63. [PubMed]
  • MacMillan V, Siesjö BK. The effect of hypercapnia upon the energy metabolism of the brain during arterial hypoxemia. Scand J Clin Lab Invest. 1972 Nov;30(3):237–244. [PubMed]
  • Makowski EL, Schneider JM, Tsoulos NG, Colwill JR, Battaglia FC, Meschia G. Cerebral blood flow, oxygen consumption, and glucose utilization of fetal lambs in utero. Am J Obstet Gynecol. 1972 Oct 1;114(3):292–303. [PubMed]
  • Pontén U, Siesjö BK. Gradients of CO2 tension in the brain. Acta Physiol Scand. 1966 Jun;67(2):129–140. [PubMed]
  • Purves MJ, James IM. Observations on the control of cerebral blood flow in the sheep fetus and newborn lamb. Circ Res. 1969 Dec;25(6):651–667. [PubMed]
  • Shapiro W, Wasserman AJ, Patterson JL., Jr Human cerebrovascular response to combined hypoxia and hypercapnia. Circ Res. 1966 Nov;19(5):903–910. [PubMed]
  • Soutter LP, Conway MJ, Parker D. A system for monitoring arterial oxygen tension in sick newborn babies. Biomed Eng. 1975 Jul;10(7):257–260. [PubMed]
  • Vannucci RC, Duffy TE. Carbohydrate metabolism in fetal and neonatal rat brain during anoxia and recovery. Am J Physiol. 1976 May;230(5):1269–1275. [PubMed]
  • Vannucci RC, Duffy TE. Cerebral metabolism in newborn dogs during reversible asphyxia. Ann Neurol. 1977 Jun;1(6):528–534. [PubMed]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...