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Br Heart J. Apr 1987; 57(4): 384–386.
PMCID: PMC1277181

Nocardial endocarditis of an aortic valve prosthesis.


The organism responsible for endocarditis of a prosthetic aortic valve was identified as Nocardia asteroides. The patient was treated with intravenous amikacin (250 mg four times a day) and intravenous imipenem (1.5 g four times a day). The valve was replaced under this new antibiotic regimen. This is the first report of survival after prosthetic valve nocardiosis.

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Selected References

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  • Falk RH, Dimock FR, Sharkey J. Prosthetic valve endocarditis resulting from Nocardia asteroides. Br Heart J. 1979 Jan;41(1):125–127. [PMC free article] [PubMed]
  • Vlachakis ND, Gazes PC, Hairston P. Nocardial endocarditis following mitral valve replacement. Chest. 1973 Feb;63(2):276–278. [PubMed]
  • Palmer DL, Harvey RL, Wheeler JK. Diagnostic and therapeutic considerations in Nocardia asteroides infection. Medicine (Baltimore) 1974 Sep;53(5):391–401. [PubMed]
  • Ivert TS, Dismukes WE, Cobbs CG, Blackstone EH, Kirklin JW, Bergdahl LA. Prosthetic valve endocarditis. Circulation. 1984 Feb;69(2):223–232. [PubMed]
  • Stasiecki P, Diehl V, Vlaho M, Krueger GR, Schaal KP. Neue erfolgreiche Therapie bei systemischer Infektion mit Nocardia asteroides. Dtsch Med Wochenschr. 1985 Nov 8;110(45):1733–1737. [PubMed]
  • Cynamon MH, Palmer GS. In vitro susceptibility of Nocardia asteroides to N-formimidoyl thienamycin and several cephalosporins. Antimicrob Agents Chemother. 1981 Dec;20(6):841–842. [PMC free article] [PubMed]
  • Gutmann L, Goldstein FW, Kitzis MD, Hautefort B, Darmon C, Acar JF. Susceptibility of Nocardia asteroides to 46 antibiotics, including 22 beta-lactams. Antimicrob Agents Chemother. 1983 Feb;23(2):248–251. [PMC free article] [PubMed]

Articles from British Heart Journal are provided here courtesy of BMJ Group


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