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Journal List > West J Med > v.133(4); Oct 1980

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West J Med. 1980 October; 133(4): 279–288.
PMCID: PMC1272302
Copyright notice
Remission-Induction Regimens in Acute Nonlymphocytic Leukemia
Donald C. Brennan, MD and Jerry P. Lewis, MD
Section of Hematology and Oncology, Department of Medicine, and the Department of Pathology, University of California, Davis, School of Medicine
University of California Davis Medical Center, Sacramento
Abstract
A sequential study was carried out involving 40 adults with acute nonlymphocytic leukemia (ANLL). The first 20 patients were treated with cytarabine (Ara-C) and 6-thioguanine (6-TG), the second 20 with a regimen that added a three-day course of daunomycin (DNM) to the Ara-C and 6-TG therapy. With both groups well matched for age, patients in the DNM-treated group had a higher complete remission (CR) rate but failed to survive longer than those in the Ara-C and 6-TG treatment group. In a comprehensive literature review of various treatments for adult ANLL, a higher CR rate but not significantly better survival for patients initially treated with DNM-combined regimens was found. Our analysis of cases and literature review suggest that while DNM is a very active drug, its use in the initial treatment of adult ANLL has not produced a significant improvement in overall survival or in survival of those brought into complete remission.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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