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Logo of cjvetresCVMACanadian Journal of Veterinary ResearchSee also Canadian Journal of Comparative MedicineJournal Web siteHow to Submit
Can J Vet Res. Jul 1996; 60(3): 222–227.
PMCID: PMC1263837

Serum haptoglobin concentration in growing swine after intranasal challenge with Bordetella bronchiseptica and toxigenic Pasteurella multocida type D.


The acute phase reaction, in association with progressive atrophic rhinitis (AR), was monitored for 3 wk using serum haptoglobin (HPT) quantification in thirty-six, 15 kg swine after intranasal challenge with varying doses of Pasteurella multocida type D (toxigenic strain) and Bordetella bronchiseptica. The challenge doses were administered alone or in combination with pigs divided into 9 isolated treatment groups. Increasing doses of B. bronchiseptica were associated with lower serum HPT (P < 0.05), whereas increasing doses of P. multocida tended to increase serum HPT (0.05 < P < 0.10). Significant and positive correlation of mean HPT and AR score was found in these pigs; increased AR scores were associated with elevated mean HPT concentration (r = 0.41, P < 0.01). A significant interaction between P. multocida and B. bronchiseptica dose indicated that increasing the dose of B. bronchiseptica, for a fixed P. multocida dose, was associated with less AR (P < 0.05). The AR scores were greater in pigs given P. multocida, than B. bronchiseptica alone. These results indicate that a complex interaction between Pasteurella multocida and Bordetella bronchiseptica causes progressive atrophic rhinitis and alters serum HPT concentration in swine.

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Selected References

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  • Kent J. Acute phase proteins: their use in veterinary diagnosis. Br Vet J. 1992 Jul-Aug;148(4):279–282. [PubMed]
  • Shim BS, Yoon CS, Oh SK, Lee TH, Kang YS. Studies on swine and canine serum haptoglobins. Biochim Biophys Acta. 1971 Jul 25;243(1):126–136. [PubMed]
  • Eurell TE, Hall WF, Bane DP. Purification of swine haptoglobin by affinity chromatography. Can J Vet Res. 1990 Oct;54(4):501–503. [PMC free article] [PubMed]
  • Hall WF, Eurell TE, Hansen RD, Herr LG. Serum haptoglobin concentration in swine naturally or experimentally infected with Actinobacillus pleuropneumoniae. J Am Vet Med Assoc. 1992 Dec 1;201(11):1730–1733. [PubMed]
  • Richter H. Haptoglobin bei Haussäugetieren. III. Mitteilung Der /aptoglobingehalt im Blutplasma und -serum von Wiederkäuern und Schweinen unter verschiedenen physiologischen Bedingungen. Arch Exp Veterinarmed. 1974;28(4):505–519. [PubMed]
  • Gatlin CL, Jordan WH, Shryock TR, Smith WC. The quantitation of turbinate atrophy in pigs to measure the severity of induced atrophic rhinitis. Can J Vet Res. 1996 Apr;60(2):121–126. [PMC free article] [PubMed]
  • Elson EC. Quantitative determination of serum haptoglobin. A simple and rapid method. Am J Clin Pathol. 1974 Nov;62(5):655–663. [PubMed]
  • Batchelor J, Fuller J, Woodman DD. A simple method for measurement of the haemoglobin binding capacity of canine haptoglobin. Lab Anim. 1989 Oct;23(4):365–369. [PubMed]
  • Goodwin RF. Monitoring for atrophic rhinitis: the problem of higher snout scores. Vet Rec. 1988 Nov 26;123(22):566–568. [PubMed]
  • Done JT, Upcott DH, Frewin DC, Hebert CN. Atrophic rhinitis: snout morphometry for quantitative assessment of conchal atrophy. Vet Rec. 1984 Jan 14;114(2):33–35. [PubMed]
  • Done JT. Porcine atrophic rhinitis: snout radiography as an aid to diagnosis and detection of the disease. Vet Rec. 1976 Jan 10;98(2):23–28. [PubMed]
  • Eckersall PD, Conner JG. Bovine and canine acute phase proteins. Vet Res Commun. 1988;12(2-3):169–178. [PubMed]
  • McSherry BJ, Horney FD, DeGroot JJ. Plasma fibrinogen levels in normal and sick cows. Can J Comp Med. 1970 Jul;34(3):191–197. [PMC free article] [PubMed]
  • Sutton RH, Johnstone M. The value of plasma fibrinogen estimations in dogs. A comparison with total leucocyte and neutrophil counts. J Small Anim Pract. 1977 Apr;18(4):277–281. [PubMed]
  • Itoh H, Tamura K, Izumi M, Motoi Y, Kidoguchi K, Funayama Y. The influence of age and health status on the serum alpha 1-acid glycoprotein level of conventional and specific pathogen-free pigs. Can J Vet Res. 1993 Apr;57(2):74–78. [PMC free article] [PubMed]
  • Sakano T, Okada M, Taneda A, Ono M, Sato S. Experimental atrophic rhinitis in 2 and 4 month old pigs infected sequentially with Bordetella bronchiseptica and toxigenic type D Pasteurella multocida. Vet Microbiol. 1992 Jun 1;31(2-3):197–206. [PubMed]

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