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Can J Vet Res. 1988 January; 52(1): 12–14. | PMCID: PMC1255392 |
Pharmacokinetics of doxycycline in dogs. R C Wilson, D T Kemp, J V Kitzman, and D D Goetsch Department of Physiology, College of Veterinary Medicine, Auburn University, Alabama 36849. Abstract Six adult dogs were given doxycycline hyclate at a dosage of 5 mg/kg of body weight intravenously so that pharmacokinetic parameters could be evaluated. Serum doxycycline concentrations were determined over a 48 h period using a modified agar well bioassay. Compartmental pharmacokinetic evaluation of the serum concentration time data indicated that doxycycline has a half-life of 10.36 h, a body clearance of 1.68 +/- 0.44 mL/min/kg, and a volume of distribution at steady state of 1.468 +/- 0.237 L/kg. Doxycycline pharmacokinetics are favorable for therapeutic use in the dog. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (487K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Barza M, Brown RB, Shanks C, Gamble C, Weinstein L. Relation between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs. Antimicrob Agents Chemother. 1975 Dec;8(6):713–720. [PubMed]
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