• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of annsurgLink to Publisher's site
Ann Surg. Dec 1985; 202(6): 696–701.
PMCID: PMC1251001

Diagnosing breast cancer using frozen sections from Tru-cut needle biopsies. Six-year experience with 162 biopsies, with emphasis on outpatient diagnosis of breast carcinoma.

Abstract

Experience in a 6-year period with 162 frozen sections from needle biopsies of the breast is reported. The technique was used mainly to diagnose breast cancer in outpatients. The results of frozen section on needle biopsies are compared with frozen sections of excisional biopsies. The sensitivity of detection in breasts containing carcinoma using frozen section of breast needle biopsies was 77%. The sensitivity of detection of carcinoma in needle biopsies subsequently shown to contain carcinoma by paraffin section was 92.8%. The specificity of frozen sections of breast needle biopsies was 86.4% and was devoid of false-positive results. Interpretation of frozen sections of needle biopsies of breast lesions is reliable when performed by experienced surgeons and handled and interpreted by experienced pathologists.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.5M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Fisher B, Gebhardt MC. The evolution of breast cancer surgery: past, present, and future. Semin Oncol. 1978 Dec;5(4):385–394. [PubMed]
  • Cheek JH, Sears AD. Results of breast biopsies for mammographic findings. Am J Surg. 1978 Dec;136(6):726–729. [PubMed]
  • Rilke F, Andreola S, Carbone A, Clemente C, Pilotti S. The importance of pathology in prognosis and management of breast cancer. Semin Oncol. 1978 Dec;5(4):360–372. [PubMed]
  • Bauermeister DE. The role and limitations of frozen section and needle aspiration biopsy in breast cancer diagnosis. Cancer. 1980 Aug 15;46(4 Suppl):947–949. [PubMed]
  • Bibbo M, Zuspan FP. Fine-needle aspiration of the breast in an obstetrics and gynecology hospital. Am J Obstet Gynecol. 1975 Jun 15;122(4):525–526. [PubMed]
  • Frable WJ. Thin-needle aspiration biopsy. A personal experience with 469 cases. Am J Clin Pathol. 1976 Feb;65(2):168–182. [PubMed]
  • Furnival CM, Hocking MA, Hughes HE, Reid MM, Blumgart LH. Aspiration cytology in breast cancer. Its relevance to diagnosis. Lancet. 1975 Sep 6;2(7932):446–449. [PubMed]
  • Gardecki TI, Hogbin BM, Melcher DH, Smith RS. Aspiration cytology in the preoperative management of breast cancer. Lancet. 1980 Oct 11;2(8198):790–792. [PubMed]
  • Kline TS, Neal HS. Needle aspiration biopsy: a critical appraisal. Eight years and 3,267 specimens later. JAMA. 1978 Jan 2;239(1):36–39. [PubMed]
  • Magarey CJ, Watson WJ. The outpatient diagnosis of breast lumps. Aust N Z J Surg. 1976 Nov;46(4):344–349. [PubMed]
  • Rosen P, Hajdu SI, Robbins G, Foote FW., Jr Diagnosis of carcinoma of the breast by aspiration biopsy. Surg Gynecol Obstet. 1972 May;134(5):837–838. [PubMed]
  • Shabot MM, Goldberg IM, Schick P, Nieberg R, Pilch YH. Aspiration cytology is superior to Tru-Cut needle biopsy in establishing the diagnosis of clinically suspicious breast masses. Ann Surg. 1982 Aug;196(2):122–126. [PMC free article] [PubMed]
  • Webb AJ. The diagnostic cytology of breast carcinoma. Br J Surg. 1970 Apr;57(4):259–264. [PubMed]
  • Winship T. Aspiration biopsy of breast cancers by the pathologist. Am J Clin Pathol. 1969 Oct;52(4):438–440. [PubMed]
  • Zajicek J, Caspersson T, Jakobsson P, Kudynowski J, Linsk J, Us-Kraŝovec M. Cytologic diagnosis of mammary tumors from aspiration biopsy smears. Comparison of cytologic and histologic findings in 2,III lesions and diagnostic use of cytophotometry. Acta Cytol. 1970 Jul-Aug;14(7):370–376. [PubMed]
  • Elston CW, Cotton RE, Davies CJ, Blamey RW. A comparison of the use of the "Tru-Cut" needle and fine needle aspiration cytology in the pre-operative diagnosis of carcinoma of the breast. Histopathology. 1978 Jul;2(4):239–254. [PubMed]
  • Fentiman IS, Millis RR, Hayward JL. Value of needle biopsy in outpatient diagnosis of breast cancer. Arch Surg. 1980 May;115(5):652–653. [PubMed]
  • Roberts JG, Preece PE, Bolton PM, Baum M, Hughes LE. The 'tru-cut' biopsy in breast cancer. Clin Oncol. 1975 Dec;1(4):297–303. [PubMed]
  • Sappenfield RW, Beeler MF, Catrou PG, Boudreau DA. Nine-cell diagnostic decision matrix. A model of the diagnostic process; a framework for evaluating diagnostic protocols. Am J Clin Pathol. 1981 Jun;75(6):769–772. [PubMed]
  • Rosen PP. Frozen section diagnosis of breast lesions. Recent experience with 556 consecutive biopsies. Ann Surg. 1978 Jan;187(1):17–19. [PMC free article] [PubMed]
  • Martin HE, Ellis EB. BIOPSY BY NEEDLE PUNCTURE AND ASPIRATION. Ann Surg. 1930 Aug;92(2):169–181. [PMC free article] [PubMed]
  • Hirst E. Detection and diagnosis of early breast cancer. Med J Aust. 1977 Apr 9;1(15):566–567. [PubMed]
  • Wanebo HJ, Feldman PS, Wilhelm MC, Covell JL, Binns RL. Fine needle aspiration cytology in lieu of open biopsy in management of primary breast cancer. Ann Surg. 1984 May;199(5):569–579. [PMC free article] [PubMed]
  • Norton LW, Davis JR, Wiens JL, Trego DC, Dunnington GL. Accuracy of aspiration cytology in detecting breast cancer. Surgery. 1984 Oct;96(4):806–814. [PubMed]
  • Ulanow RM, Galblum L, Canter JW. Fine needle aspiration in the diagnosis and management of solid breast lesions. Am J Surg. 1984 Nov;148(5):653–657. [PubMed]
  • Vorherr H. Breast aspiration biopsy. Am J Obstet Gynecol. 1984 Jan 15;148(2):127–133. [PubMed]
  • Donegan WL, Lewis JD. Clinical diagnosis and staging of breast cancer. Semin Oncol. 1978 Dec;5(4):373–384. [PubMed]
  • Ashikari R, Huvos AG, Snyder RE, Lucas JC, Hutter RV, McDivitt RW, Schottenfeld D. Proceedings: A clinicopathologic study of atypical lesions of the breast. Cancer. 1974 Feb;33(2):310–317. [PubMed]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...