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Br Med J (Clin Res Ed). Jun 27, 1987; 294(6588): 1651–1654.
PMCID: PMC1246824

Proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus.

Abstract

The relation between diabetic microangiopathy and macroangiopathy was studied by analysing the relative mortality from cardiovascular disease in patients with insulin dependent diabetes mellitus with and without persistent proteinuria. The study group comprised 2890 diabetics diagnosed between 1933 and 1972 before the age of 31, and the study was conducted by using the linear logistic discrete failure time model. In patients with proteinuria the relative mortality from cardiovascular disease was 37 times that in the general population; in patients without proteinuria it was 4.2 times that in the general population. In both groups women had a relative mortality twice to 2.6 times that of men. In neither group was relative mortality correlated with duration of diabetes, suggesting that the association between diabetes and cardiovascular disease may be conferred by factors other than hyperglycaemia and hyperinsulinaemia. The high relative mortality from cardiovascular disease in diabetics with proteinuria indicates a strong association between diabetic microangiopathy and macroangiopathy, suggesting a common (pathogenetic?) mechanism for these two late diabetic complications.

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Selected References

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  • Borch-Johnsen K, Andersen PK, Deckert T. The effect of proteinuria on relative mortality in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1985 Aug;28(8):590–596. [PubMed]
  • Jarrett RJ. Type 2 (non-insulin-dependent) diabetes mellitus and coronary heart disease-chicken, egg or neither? Diabetologia. 1984 Feb;26(2):99–102. [PubMed]
  • Goodkin G. Mortality factors in diabetes. A 20 year mortality study. J Occup Med. 1975 Nov;17(11):716–721. [PubMed]
  • Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med. 1984 Feb 9;310(6):356–360. [PubMed]
  • Jarrett RJ, Viberti GC, Argyropoulos A, Hill RD, Mahmud U, Murrells TJ. Microalbuminuria predicts mortality in non-insulin-dependent diabetics. Diabet Med. 1984 May;1(1):17–19. [PubMed]
  • Borch-Johnsen K, Kreiner S, Deckert T. Mortality of type 1 (insulin-dependent) diabetes mellitus in Denmark: a study of relative mortality in 2930 Danish type 1 diabetic patients diagnosed from 1933 to 1972. Diabetologia. 1986 Nov;29(11):767–772. [PubMed]
  • Parving HH, Andersen AR, Smidt UM, Oxenbøll B, Edsberg B, Christiansen JS. Diabetic nephropathy and arterial hypertension. Diabetologia. 1983 Jan;24(1):10–12. [PubMed]
  • Christlieb AR. The hypertensions of diabetes. Diabetes Care. 1982 Jan-Feb;5(1):50–58. [PubMed]
  • Barnett AH, Pyke DA. The genetics of diabetic complications. Clin Endocrinol Metab. 1986 Nov;15(4):715–726. [PubMed]
  • Feldt-Rasmussen B. Increased transcapillary escape rate of albumin in type 1 (insulin-dependent) diabetic patients with microalbuminuria. Diabetologia. 1986 May;29(5):282–286. [PubMed]
  • Panzram G, Ruttmann B. Prognose des Diabetes mellitus nach Frühdiagnose durch Glucosurie-Screening. Ergebnisse einer 10jährigen Verlaufskontrolle. Schweiz Med Wochenschr. 1978 Feb 18;108(7):221–225. [PubMed]
  • Waller BF, Palumbo PJ, Lie JT, Roberts WC. Status of the coronary arteries at necropsy in diabetes mellitus with onset after age 30 years. Analysis of 229 diabetic patients with and without clinical evidence of coronary heart disease and comparison to 183 control subjects. Am J Med. 1980 Oct;69(4):498–506. [PubMed]
  • Barrett-Connor E, Wingard DL. Sex differential in ischemic heart disease mortality in diabetics: a prospective population-based study. Am J Epidemiol. 1983 Oct;118(4):489–496. [PubMed]
  • Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979 May 11;241(19):2035–2038. [PubMed]
  • Schroll M, Larsen S. A ten-year prospective study, 1964-1974, of cardiovascular risk factors in men and women from the Glostrup population born in 1914. Multivariate analyses. Dan Med Bull. 1981 Dec;28(6):236–251. [PubMed]

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