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Environ Health Perspect. 2001 Oct; 109(10): 1027–1031.
PMCID: PMC1242079
Research Article

Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes.


We investigated a potential mechanism for the estrogenic properties of three chloro-s-triazine herbicides and six metabolites in vitro in several cell systems. We determined effects on human aromatase (CYP19), the enzyme that converts androgens to estrogens, in H295R (adrenocortical carcinoma), JEG-3 (placental choriocarcinoma), and MCF-7 (breast cancer) cells; we determined effects on estrogen receptor-mediated induction of vitellogenin in primary hepatocyte cultures of adult male carp (Cyprinus carpio). In addition to atrazine, simazine, and propazine, two metabolites--atrazine-desethyl and atrazine-desisopropyl--induced aromatase activity in H295R cells concentration-dependently (0.3-30 microM) and with potencies similar to those of the parent triazines. After a 24-hr exposure to 30 microM of the triazines, an apparent maximum induction of about 2- to 2.5-fold was achieved. The induction responses were confirmed by similar increases in CYP19 mRNA levels, determined by reverse-transcriptase polymerase chain reaction. In JEG-3 cells, where basal aromatase expression is about 15-fold greater than in H295R cells, the induction responses were similar but less pronounced; aromatase expression in MCF-7 cells was neither detectable nor inducible under our culture conditions. The fully dealkylated metabolite atrazine-desethyl-desisopropyl and the three hydroxylated metabolites (2-OH-atrazine-desethyl, -desisopropyl, and -desethyl-desisopropyl) did not induce aromatase activity. None of the triazine herbicides nor their metabolites induced vitellogenin production in male carp hepatocytes; nor did they antagonize the induction of vitellogenin by 100 nM (EC(50) 17beta-estradiol. These findings together with other reports indicate that the estrogenic effects associated with the triazine herbicides in vivo are not estrogen receptor-mediated, but may be explained partly by their ability to induce aromatase in vitro.

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Selected References

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  • Khan SU, Foster TS. Residues of atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine)and its metabolities in chicken tissues. J Agric Food Chem. 1976 Jul-Aug;24(4):768–771. [PubMed]
  • Donna A, Crosignani P, Robutti F, Betta PG, Bocca R, Mariani N, Ferrario F, Fissi R, Berrino F. Triazine herbicides and ovarian epithelial neoplasms. Scand J Work Environ Health. 1989 Feb;15(1):47–53. [PubMed]
  • Kettles MK, Browning SR, Prince TS, Horstman SW. Triazine herbicide exposure and breast cancer incidence: an ecologic study of Kentucky counties. Environ Health Perspect. 1997 Nov;105(11):1222–1227. [PMC free article] [PubMed]
  • Pintér A, Török G, Börzsönyi M, Surján A, Csík M, Kelecsényi Z, Kocsis Z. Long-term carcinogenicity bioassay of the herbicide atrazine in F344 rats. Neoplasma. 1990;37(5):533–544. [PubMed]
  • Wetzel LT, Luempert LG, 3rd, Breckenridge CB, Tisdel MO, Stevens JT, Thakur AK, Extrom PJ, Eldridge JC. Chronic effects of atrazine on estrus and mammary tumor formation in female Sprague-Dawley and Fischer 344 rats. J Toxicol Environ Health. 1994 Oct;43(2):169–182. [PubMed]
  • Brawer JR, Sonnenschein C. Cytopathological effects of estradiol on the arcuate nucleus of the female rat. A possible mechanism for pituitary tumorigenesis. Am J Anat. 1975 Sep;144(1):57–88. [PubMed]
  • Stoker TE, Robinette CL, Cooper RL. Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring. Toxicol Sci. 1999 Nov;52(1):68–79. [PubMed]
  • Tangbanluekal L, Robinette CL. Prolactin mediates estradiol-induced inflammation in the lateral prostate of Wistar rats. Endocrinology. 1993 Jun;132(6):2407–2416. [PubMed]
  • Cooper RL, Stoker TE, Tyrey L, Goldman JM, McElroy WK. Atrazine disrupts the hypothalamic control of pituitary-ovarian function. Toxicol Sci. 2000 Feb;53(2):297–307. [PubMed]
  • Connor K, Howell J, Chen I, Liu H, Berhane K, Sciarretta C, Safe S, Zacharewski T. Failure of chloro-S-triazine-derived compounds to induce estrogen receptor-mediated responses in vivo and in vitro. Fundam Appl Toxicol. 1996 Mar;30(1):93–101. [PubMed]
  • Tennant MK, Hill DS, Eldridge JC, Wetzel LT, Breckenridge CB, Stevens JT. Chloro-s-triazine antagonism of estrogen action: limited interaction with estrogen receptor binding. J Toxicol Environ Health. 1994 Oct;43(2):197–211. [PubMed]
  • Tennant MK, Hill DS, Eldridge JC, Wetzel LT, Breckenridge CB, Stevens JT. Possible antiestrogenic properties of chloro-s-triazines in rat uterus. J Toxicol Environ Health. 1994 Oct;43(2):183–196. [PubMed]
  • Babić-Gojmerac T, Kniewald Z, Kniewald J. Testosterone metabolism in neuroendocrine organs in male rats under atrazine and deethylatrazine influence. J Steroid Biochem. 1989 Jul;33(1):141–146. [PubMed]
  • Lang DH, Rettie AE, Böcker RH. Identification of enzymes involved in the metabolism of atrazine, terbuthylazine, ametryne, and terbutryne in human liver microsomes. Chem Res Toxicol. 1997 Sep;10(9):1037–1044. [PubMed]
  • Hanioka N, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M. In vitro metabolism of chlorotriazines: characterization of simazine, atrazine, and propazine metabolism using liver microsomes from rats treated with various cytochrome P450 inducers. Toxicol Appl Pharmacol. 1999 May 1;156(3):195–205. [PubMed]
  • Lang D, Criegee D, Grothusen A, Saalfrank RW, Böcker RH. In vitro metabolism of atrazine, terbuthylazine, ametryne, and terbutryne in rats, pigs, and humans. Drug Metab Dispos. 1996 Aug;24(8):859–865. [PubMed]
  • Sanderson JT, Seinen W, Giesy JP, van den Berg M. 2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity? Toxicol Sci. 2000 Mar;54(1):121–127. [PubMed]
  • Smeets JM, Rankouhi TR, Nichols KM, Komen H, Kaminski NE, Giesy JP, van den Berg M. In vitro vitellogenin production by carp (Cyprinus carpio) hepatocytes as a screening method for determining (anti)estrogenic activity of xenobiotics. Toxicol Appl Pharmacol. 1999 May 15;157(1):68–76. [PubMed]
  • Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods. 1986 May 22;89(2):271–277. [PubMed]
  • Udenfriend S, Stein S, Böhlen P, Dairman W, Leimgruber W, Weigele M. Fluorescamine: a reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range. Science. 1972 Nov 24;178(4063):871–872. [PubMed]
  • Lephart ED, Simpson ER. Assay of aromatase activity. Methods Enzymol. 1991;206:477–483. [PubMed]
  • Letcher RJ, van Holsteijn I, Drenth HJ, Norstrom RJ, Bergman A, Safe S, Pieters R, van den Berg M. Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells. Toxicol Appl Pharmacol. 1999 Oct 1;160(1):10–20. [PubMed]
  • Brodie AM, Schwarzel WC, Shaikh AA, Brodie HJ. The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen-dependent processes in reproduction and breast cancer. Endocrinology. 1977 Jun;100(6):1684–1695. [PubMed]
  • Jørgensen L, Brünner N, Spang-Thomsen M, James MR, Clarke R, Dombernowsky P, Svenstrup B. Steroid metabolism in the hormone dependent MCF-7 human breast carcinoma cell line and its two hormone resistant subpopulations MCF-7/LCC1 and MCF-7/LCC2. J Steroid Biochem Mol Biol. 1997 Nov-Dec;63(4-6):275–281. [PubMed]
  • Castagnetta LA, Granata OM, Bellavia V, Amodio R, Scaccianoce E, Notarbartolo M, Follari MR, Miceli MD, Carruba G. Product of aromatase activity in intact LNCaP and MCF-7 human cancer cells. J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):287–292. [PubMed]
  • Kudoh M, Susaki Y, Ideyama Y, Nanya T, Mori M, Shikama H, Fujikura T. Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell. J Steroid Biochem Mol Biol. 1996 May;58(2):189–194. [PubMed]
  • Ciolino HP, Wang TT, Sathyamoorthy N. Inhibition of aromatase activity and expression in MCF-7 cells by the chemopreventive retinoid N-(4-hydroxy-phenyl)-retinamide. Br J Cancer. 2000 Aug;83(3):333–337. [PMC free article] [PubMed]
  • Stevens JT, Breckenridge CB, Wetzel LT, Gillis JH, Luempert LG, 3rd, Eldridge JC. Hypothesis for mammary tumorigenesis in Sprague-Dawley rats exposed to certain triazine herbicides. J Toxicol Environ Health. 1994 Oct;43(2):139–153. [PubMed]
  • Stoker TE, Laws SC, Guidici DL, Cooper RL. The effect of atrazine on puberty in male wistar rats: an evaluation in the protocol for the assessment of pubertal development and thyroid function. Toxicol Sci. 2000 Nov;58(1):50–59. [PubMed]
  • Steele AW, Eisert S, Health Denver. Enhanced Clinic Productivity with an Automated Appointment System. Proc AMIA Symp. 2001:1035–1035. [PMC free article]
  • Craighead JE, Mossman BT. The pathogenesis of asbestos-associated diseases. N Engl J Med. 1982 Jun 17;306(24):1446–1455. [PubMed]
  • Mossman BT, Bignon J, Corn M, Seaton A, Gee JB. Asbestos: scientific developments and implications for public policy. Science. 1990 Jan 19;247(4940):294–301. [PubMed]
  • Ellouk SA, Jaurand MC. Review of animal/in vitro data on biological effects of man-made fibers. Environ Health Perspect. 1994 Jun;102 (Suppl 2):47–61. [PMC free article] [PubMed]
  • Bunn WB, 3rd, Bender JR, Hesterberg TW, Chase GR, Konzen JL. Recent studies of man-made vitreous fibers. Chronic animal inhalation studies. J Occup Med. 1993 Feb;35(2):101–113. [PubMed]
  • Hesterberg TW, Chase G, Axten C, Miller WC, Musselman RP, Kamstrup O, Hadley J, Morscheidt C, Bernstein DM, Thevenaz P. Biopersistence of synthetic vitreous fibers and amosite asbestos in the rat lung following inhalation. Toxicol Appl Pharmacol. 1998 Aug;151(2):262–275. [PubMed]
  • Stanton MF, Layard M, Tegeris A, Miller E, May M, Morgan E, Smith A. Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst. 1981 Nov;67(5):965–975. [PubMed]
  • Davis JM, Addison J, Bolton RE, Donaldson K, Jones AD, Smith T. The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection. Br J Exp Pathol. 1986 Jun;67(3):415–430. [PMC free article] [PubMed]
  • Roller M, Pott F, Kamino K, Althoff GH, Bellmann B. Results of current intraperitoneal carcinogenicity studies with mineral and vitreous fibres. Exp Toxicol Pathol. 1996 Jan;48(1):3–12. [PubMed]
  • Kamp DW, Graceffa P, Pryor WA, Weitzman SA. The role of free radicals in asbestos-induced diseases. Free Radic Biol Med. 1992;12(4):293–315. [PubMed]
  • Brown DM, Fisher C, Donaldson K. Free radical activity of synthetic vitreous fibers: iron chelation inhibits hydroxyl radical generation by refractory ceramic fiber. J Toxicol Environ Health A. 1998 Apr 10;53(7):545–561. [PubMed]
  • Mossman BT, Marsh JP, Shatos MA, Doherty J, Gilbert R, Hill S. Implication of active oxygen species as second messengers of asbestos toxicity. Drug Chem Toxicol. 1987;10(1-2):157–180. [PubMed]
  • Mossman BT, Sesko AM. In vitro assays to predict the pathogenicity of mineral fibers. Toxicology. 1990 Jan-Feb;60(1-2):53–61. [PubMed]
  • Hansen K, Mossman BT. Generation of superoxide (O2-.) from alveolar macrophages exposed to asbestiform and nonfibrous particles. Cancer Res. 1987 Mar 15;47(6):1681–1686. [PubMed]
  • Ruotsalainen M, Hirvonen MR, Luoto K, Savolainen KM. Production of reactive oxygen species by man-made vitreous fibres in human polymorphonuclear leukocytes. Hum Exp Toxicol. 1999 Jun;18(6):354–362. [PubMed]
  • Ohyama M, Otake T, Morinaga K. The chemiluminescent response from human monocyte-derived macrophages exposed to various mineral fibers of different sizes. Ind Health. 2000 Jul;38(3):289–293. [PubMed]
  • Kohyama N, Tanaka I, Tomita M, Kudo M, Shinohara Y. Preparation and characteristics of standard reference samples of fibrous minerals for biological experiments. Ind Health. 1997 Jul;35(3):415–432. [PubMed]
  • Yamato H, Morimoto Y, Tsuda T, Ohgami A, Kohyama N, Tanaka I. Fiber numbers per unit weight of JFM standard reference samples determined with a scanning electron microscope. Japan Fibrous Material. Ind Health. 1998 Oct;36(4):384–387. [PubMed]
  • Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77–89. [PubMed]
  • Nyberg P, Klockars M. Measurement of reactive oxygen metabolites produced by human monocyte-derived macrophages exposed to mineral dusts. Int J Exp Pathol. 1990 Aug;71(4):537–544. [PMC free article] [PubMed]
  • Vallyathan V, Mega JF, Shi X, Dalal NS. Enhanced generation of free radicals from phagocytes induced by mineral dusts. Am J Respir Cell Mol Biol. 1992 Apr;6(4):404–413. [PubMed]
  • Weitzman SA, Graceffa P. Asbestos catalyzes hydroxyl and superoxide radical generation from hydrogen peroxide. Arch Biochem Biophys. 1984 Jan;228(1):373–376. [PubMed]
  • Halliwell B, Gutteridge JM. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys. 1986 May 1;246(2):501–514. [PubMed]
  • Halliwell B, Gutteridge JM. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J. 1984 Apr 1;219(1):1–14. [PMC free article] [PubMed]
  • Stanton MF, Laynard M, Tegeris A, Miller E, May M, Kent E. Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J Natl Cancer Inst. 1977 Mar;58(3):587–603. [PubMed]
  • Archer VE. Carcinogenicity of fibers and films: a theory. Med Hypotheses. 1979 Nov;5(11):1257–1262. [PubMed]
  • Hesterberg TW, Axten C, McConnell EE, Oberdörster G, Everitt J, Miiller WC, Chevalier J, Chase GR, Thevenaz P. Chronic inhalation study of fiber glass and amosite asbestos in hamsters: twelve-month preliminary results. Environ Health Perspect. 1997 Sep;105 (Suppl 5):1223–1229. [PMC free article] [PubMed]
  • Hill IM, Beswick PH, Donaldson K. Differential release of superoxide anions by macrophages treated with long and short fibre amosite asbestos is a consequence of differential affinity for opsonin. Occup Environ Med. 1995 Feb;52(2):92–96. [PMC free article] [PubMed]
  • Goodglick LA, Kane AB. Cytotoxicity of long and short crocidolite asbestos fibers in vitro and in vivo. Cancer Res. 1990 Aug 15;50(16):5153–5163. [PubMed]
  • Dockery DW, Pope CA., 3rd Acute respiratory effects of particulate air pollution. Annu Rev Public Health. 1994;15:107–132. [PubMed]
  • Vedal S. Ambient particles and health: lines that divide. J Air Waste Manag Assoc. 1997 May;47(5):551–581. [PubMed]
  • Dockery DW, Pope CA, 3rd, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG, Jr, Speizer FE. An association between air pollution and mortality in six U.S. cities. N Engl J Med. 1993 Dec 9;329(24):1753–1759. [PubMed]
  • Pope CA, 3rd, Thun MJ, Namboodiri MM, Dockery DW, Evans JS, Speizer FE, Heath CW., Jr Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):669–674. [PubMed]
  • Abbey DE, Nishino N, McDonnell WF, Burchette RJ, Knutsen SF, Lawrence Beeson W, Yang JX. Long-term inhalable particles and other air pollutants related to mortality in nonsmokers. Am J Respir Crit Care Med. 1999 Feb;159(2):373–382. [PubMed]
  • Seaton A, MacNee W, Donaldson K, Godden D. Particulate air pollution and acute health effects. Lancet. 1995 Jan 21;345(8943):176–178. [PubMed]
  • Oberdörster G, Ferin J, Gelein R, Soderholm SC, Finkelstein J. Role of the alveolar macrophage in lung injury: studies with ultrafine particles. Environ Health Perspect. 1992 Jul;97:193–199. [PMC free article] [PubMed]
  • Ferin J, Oberdörster G, Penney DP. Pulmonary retention of ultrafine and fine particles in rats. Am J Respir Cell Mol Biol. 1992 May;6(5):535–542. [PubMed]
  • Churg A. The uptake of mineral particles by pulmonary epithelial cells. Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1124–1140. [PubMed]
  • Churg A, Brauer M. Human lung parenchyma retains PM2.5. Am J Respir Crit Care Med. 1997 Jun;155(6):2109–2111. [PubMed]
  • Jörres R, Magnussen H. Influence of short-term passive smoking on symptoms, lung mechanics and airway responsiveness in asthmatic subjects and healthy controls. Eur Respir J. 1992 Sep;5(8):936–944. [PubMed]
  • Danuser B, Weber A, Hartmann AL, Krueger H. Effects of a bronchoprovocation challenge test with cigarette sidestream smoke on sensitive and healthy adults. Chest. 1993 Feb;103(2):353–358. [PubMed]
  • Nowak D, Jörres R, Schmidt A, Magnussen H. Effect of 3 hours' passive smoke exposure in the evening on airway tone and responsiveness until next morning. Int Arch Occup Environ Health. 1997;69(2):125–133. [PubMed]
  • Weber A. Irritating and annoying effects of passive smoking. Tokai J Exp Clin Med. 1985 Aug;10(4):341–345. [PubMed]
  • Oglesby L, Künzli N, Rösli M, Braun-Fahrländer C, Mathys P, Stern W, Jantunen M, Kousa A. Validity of ambient levels of fine particles as surrogate for personal exposure to outdoor air pollution--results of the European EXPOLIS-EAS Study (Swiss Center Basel). J Air Waste Manag Assoc. 2000 Jul;50(7):1251–1261. [PubMed]
  • Jenkins RA, Counts RW. Occupational exposure to environmental tobacco smoke: results of two personal exposure studies. Environ Health Perspect. 1999 May;107 (Suppl 2):341–348. [PMC free article] [PubMed]
  • Junker M, Koller T, Monn C. An assessment of indoor air contaminants in buildings with recreational activity. Sci Total Environ. 2000 Feb 10;246(2-3):139–152. [PubMed]
  • Cummings KM, Zaki A, Markello S. Variation in sensitivity to environmental tobacco smoke among adult non-smokers. Int J Epidemiol. 1991 Mar;20(1):121–125. [PubMed]
  • Huber G, Hangartner M, Gierer R. Sensorische Geruchsmessung. Soz Praventivmed. 1981 Jul;26(3):179–182. [PubMed]
  • Lang PJ, Bradley MM, Cuthbert BN. Emotion, attention, and the startle reflex. Psychol Rev. 1990 Jul;97(3):377–395. [PubMed]
  • Miltner W, Matjak M, Braun C, Diekmann H, Brody S. Emotional qualities of odors and their influence on the startle reflex in humans. Psychophysiology. 1994 Jan;31(1):107–110. [PubMed]
  • Anthony BJ, Graham FK. Blink reflex modification by selective attention: evidence for the modulation of 'automatic' processing. Biol Psychol. 1985 Aug;21(1):43–59. [PubMed]
  • Schicatano EJ, Blumenthal TD. The effects of caffeine and directed attention on acoustic startle habituation. Pharmacol Biochem Behav. 1998 Jan;59(1):145–150. [PubMed]
  • Warren DW, Walker JC, Drake AF, Lutz RW. Effects of odorants and irritants on respiratory behavior. Laryngoscope. 1994 May;104(5 Pt 1):623–626. [PubMed]
  • Junker M, Koller T, Monn C. An assessment of indoor air contaminants in buildings with recreational activity. Sci Total Environ. 2000 Feb 10;246(2-3):139–152. [PubMed]
  • Ehrlichman H, Brown S, Zhu J, Warrenburg S. Startle reflex modulation during exposure to pleasant and unpleasant odors. Psychophysiology. 1995 Mar;32(2):150–154. [PubMed]
  • Ehrlichman H, Kuhl SB, Zhu J, Warrenburg S. Startle reflex modulation by pleasant and unpleasant odors in a between-subjects design. Psychophysiology. 1997 Nov;34(6):726–729. [PubMed]
  • Muramatsu T, Weber A, Muramatsu S, Akermann F. An experimental study on irritation and annoyance due to passive smoking. Int Arch Occup Environ Health. 1983;51(4):305–317. [PubMed]
  • Winneke G. Structure and determinants of psychophysiological response to odorant/irritant air pollution. Ann N Y Acad Sci. 1992 Apr 30;641:261–276. [PubMed]
  • Repace JL, Lowrey AH. Indoor air pollution, tobacco smoke, and public health. Science. 1980 May 2;208(4443):464–472. [PubMed]
  • Schwartz J, Norris G, Larson T, Sheppard L, Claiborne C, Koenig J. Episodes of high coarse particle concentrations are not associated with increased mortality. Environ Health Perspect. 1999 May;107(5):339–342. [PMC free article] [PubMed]
  • Chen C, Chock DP, Winkler SL. A simulation study of confounding in generalized linear models for air pollution epidemiology. Environ Health Perspect. 1999 Mar;107(3):217–222. [PMC free article] [PubMed]
  • Lipfert FW, Wyzga RE. Statistical considerations in determining the health significance of constituents of airborne particulate matter. J Air Waste Manag Assoc. 1999 Sep;49(9 Spec No):182–191. [PubMed]
  • Samet JM, Dominici F, Curriero FC, Coursac I, Zeger SL. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med. 2000 Dec 14;343(24):1742–1749. [PubMed]
  • Schwartz J. Assessing confounding, effect modification, and thresholds in the association between ambient particles and daily deaths. Environ Health Perspect. 2000 Jun;108(6):563–568. [PMC free article] [PubMed]
  • Fairley D. Daily mortality and air pollution in Santa Clara County, California: 1989-1996. Environ Health Perspect. 1999 Aug;107(8):637–641. [PMC free article] [PubMed]
  • Sarnat JA, Koutrakis P, Suh HH. Assessing the relationship between personal particulate and gaseous exposures of senior citizens living in Baltimore, MD. J Air Waste Manag Assoc. 2000 Jul;50(7):1184–1198. [PubMed]
  • Long CM, Suh HH, Koutrakis P. Characterization of indoor particle sources using continuous mass and size monitors. J Air Waste Manag Assoc. 2000 Jul;50(7):1236–1250. [PubMed]
  • Chang LT, Koutrakis P, Catalano PJ, Suh HH. Hourly personal exposures to fine particles and gaseous pollutants--results from Baltimore, Maryland. J Air Waste Manag Assoc. 2000 Jul;50(7):1223–1235. [PubMed]
  • Levy JI, Lee K, Spengler JD, Yanagisawa Y. Impact of residential nitrogen dioxide exposure on personal exposure: an international study. J Air Waste Manag Assoc. 1998 Jun;48(6):553–560. [PubMed]
  • Liu LJ, Delfino R, Koutrakis P. Ozone exposure assessment in a southern California community. Environ Health Perspect. 1997 Jan;105(1):58–65. [PMC free article] [PubMed]
  • Janssen NA, Hoek G, Brunekreef B, Harssema H, Mensink I, Zuidhof A. Personal sampling of particles in adults: relation among personal, indoor, and outdoor air concentrations. Am J Epidemiol. 1998 Mar 15;147(6):537–547. [PubMed]
  • Alm S, Mukala K, Pasanen P, Tiittanen P, Ruuskanen J, Tuomisto J, Jantunen MJ. Personal NO2 exposures of preschool children in Helsinki. J Expo Anal Environ Epidemiol. 1998 Jan-Mar;8(1):79–100. [PubMed]
  • Burnett RT, Brook JR, Yung WT, Dales RE, Krewski D. Association between ozone and hospitalization for respiratory diseases in 16 Canadian cities. Environ Res. 1997 Jan;72(1):24–31. [PubMed]
  • Clarke RW, Coull B, Reinisch U, Catalano P, Killingsworth CR, Koutrakis P, Kavouras I, Murthy GG, Lawrence J, Lovett E, et al. Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines. Environ Health Perspect. 2000 Dec;108(12):1179–1187. [PMC free article] [PubMed]
  • Tyler CR, Jobling S, Sumpter JP. Endocrine disruption in wildlife: a critical review of the evidence. Crit Rev Toxicol. 1998 Jul;28(4):319–361. [PubMed]
  • Vos JG, Dybing E, Greim HA, Ladefoged O, Lambré C, Tarazona JV, Brandt I, Vethaak AD. Health effects of endocrine-disrupting chemicals on wildlife, with special reference to the European situation. Crit Rev Toxicol. 2000 Jan;30(1):71–133. [PubMed]
  • White R, Jobling S, Hoare SA, Sumpter JP, Parker MG. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology. 1994 Jul;135(1):175–182. [PubMed]
  • Arnold SF, Vonier PM, Collins BM, Klotz DM, Guillette LJ, Jr, McLachlan JA. In vitro synergistic interaction of alligator and human estrogen receptors with combinations of environmental chemicals. Environ Health Perspect. 1997 Apr;105 (Suppl 3):615–618. [PMC free article] [PubMed]
  • Colborn T, vom Saal FS, Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect. 1993 Oct;101(5):378–384. [PMC free article] [PubMed]
  • Chapin RE, Stevens JT, Hughes CL, Kelce WR, Hess RA, Daston GP. Endocrine modulation of reproduction. Fundam Appl Toxicol. 1996 Jan;29(1):1–17. [PubMed]
  • Gray LE, Jr, Ostby JS, Kelce WR. Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. Toxicol Appl Pharmacol. 1994 Nov;129(1):46–52. [PubMed]
  • Kelce WR, Monosson E, Gamcsik MP, Laws SC, Gray LE., Jr Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol Appl Pharmacol. 1994 Jun;126(2):276–285. [PubMed]
  • Kelce WR, Stone CR, Laws SC, Gray LE, Kemppainen JA, Wilson EM. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature. 1995 Jun 15;375(6532):581–585. [PubMed]
  • Wong C, Kelce WR, Sar M, Wilson EM. Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J Biol Chem. 1995 Aug 25;270(34):19998–20003. [PubMed]
  • Kelce WR, Lambright CR, Gray LE, Jr, Roberts KP. Vinclozolin and p,p'-DDE alter androgen-dependent gene expression: in vivo confirmation of an androgen receptor-mediated mechanism. Toxicol Appl Pharmacol. 1997 Jan;142(1):192–200. [PubMed]
  • Kelce WR, Wilson EM. Environmental antiandrogens: developmental effects, molecular mechanisms, and clinical implications. J Mol Med (Berl) 1997 Mar;75(3):198–207. [PubMed]
  • Gray LE, Jr, Ostby J. Effects of pesticides and toxic substances on behavioral and morphological reproductive development: endocrine versus nonendocrine mechanisms. Toxicol Ind Health. 1998 Jan-Apr;14(1-2):159–184. [PubMed]
  • Wolf C, Jr, Lambright C, Mann P, Price M, Cooper RL, Ostby J, Gray LE., Jr Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health. 1999 Jan-Mar;15(1-2):94–118. [PubMed]
  • Gray LE, Jr, Ostby J, Monosson E, Kelce WR. Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat. Toxicol Ind Health. 1999 Jan-Mar;15(1-2):48–64. [PubMed]
  • Ashby J, Lefevre PA. The weanling male rat as an assay for endocrine disruption: preliminary observations. Regul Toxicol Pharmacol. 1997 Dec;26(3):330–337. [PubMed]
  • Monosson E, Kelce WR, Lambright C, Ostby J, Gray LE., Jr Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor function in the male rat. Toxicol Ind Health. 1999 Jan-Mar;15(1-2):65–79. [PubMed]
  • Roberts KP, Zirkin BR. Androgen regulation of spermatogenesis in the rat. Ann N Y Acad Sci. 1991;637:90–106. [PubMed]
  • Guillette LJ, Jr, Gross TS, Masson GR, Matter JM, Percival HF, Woodward AR. Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. Environ Health Perspect. 1994 Aug;102(8):680–688. [PMC free article] [PubMed]
  • Guillette LJ, Jr, Pickford DB, Crain DA, Rooney AA, Percival HF. Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment. Gen Comp Endocrinol. 1996 Jan;101(1):32–42. [PubMed]
  • Sperry TS, Thomas P. Characterization of two nuclear androgen receptors in Atlantic croaker: comparison of their biochemical properties and binding specificities. Endocrinology. 1999 Apr;140(4):1602–1611. [PubMed]
  • Sperry TS, Thomas P. Identification of two nuclear androgen receptors in kelp bass (Paralabrax clathratus) and their binding affinities for xenobiotics: comparison with Atlantic croaker (Micropogonias undulatus) androgen receptors. Biol Reprod. 1999 Oct;61(4):1152–1161. [PubMed]
  • Makynen EA, Kahl MD, Jensen KM, Tietge JE, Wells KL, Van Der Kraak G, Ankley GT. Effects of the mammalian antiandrogen vinclozolin on development and reproduction of the fathead minnow (Pimephales promelas). Aquat Toxicol. 2000 Apr 1;48(4):461–475. [PubMed]
  • Stahlschmidt-Allner P, Allner B, Römbke J, Knacker T. Endocrine disrupters in the aquatic environment. Environ Sci Pollut Res Int. 1997;4(3):155–162. [PubMed]
  • Matthews IM, Evans JP, Magurran AE. Male display rate reveals ejaculate characteristics in the Trinidadian guppy, Poecilia reticulata. Proc Biol Sci. 1997 May 22;264(1382):695–700. [PMC free article]
  • Toft G, Baatrup E. Sexual characteristics are altered by 4-tert-octylphenol and 17beta-estradiol in the adult male guppy (Poecilia reticulata). Ecotoxicol Environ Saf. 2001 Jan;48(1):76–84. [PubMed]
  • Pandey S. Effects of hypophysectomy on the testis and secondary sex characters of the adult guppy Poecilia reticulata Peters. Can J Zool. 1969 Sep;47(5):775–781. [PubMed]
  • Bayley M, Nielsen JR, Baatrup E. Guppy sexual behavior as an effect biomarker of estrogen mimics. Ecotoxicol Environ Saf. 1999 May;43(1):68–73. [PubMed]
  • Liley NR. The endocrine control of reproductive behaviour in the female guppy, Poecilia reticulata peters. Anim Behav. 1968 Apr-Jul;16(2):318–331. [PubMed]
  • Carlson DB, Curtis LR, Williams DE. Salmonid sexual development is not consistently altered by embryonic exposure to endocrine-active chemicals. Environ Health Perspect. 2000 Mar;108(3):249–255. [PMC free article] [PubMed]
  • Pandey S. Effects of methyl testosterone on the testis and secondary sex characters of the hypophysectomized adult guppy Poecilia reticulata Peters. Can J Zool. 1969 Sep;47(5):783–786. [PubMed]
  • Pandey S. The role of pituitary and gonadal hormones in the differentiation of testis and secondary sex characters of the juvenile guppy Poecilia reticulata peters. Biol Reprod. 1969 Sep;1(3):272–281. [PubMed]
  • Consensus development meeting 1995: combined oral contraceptives and cardiovascular disease. The Consensus Statement issued after the Second European Conference on Sex Steroids and Metabolism, Amsterdam, November 1995. Writing Committee. Gynecol Endocrinol. 1996 Feb;10(1):1–5. [PubMed]
  • Simard J, Singh SM, Labrie F. Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters. Urology. 1997 Apr;49(4):580–589. [PubMed]
  • Kime DE. A strategy for assessing the effects of xenobiotics on fish reproduction. Sci Total Environ. 1999 Jan 12;225(1-2):3–11. [PubMed]
  • Rouse EF, Coppenger CJ, Barnes PR. The effect of an androgen inhibitor on behavior and testicular morphology in the stickleback Gasterosteus aculeatus. Horm Behav. 1977 Aug;9(1):8–18. [PubMed]
  • Haider SG. Histophysiological effects of an antiandrogen (cyproterone acetate) on the testis of the frog Rana temporaria. Acta Anat (Basel) 1980;106(3):387–391. [PubMed]
  • Balbontin JB, Ferrario M. Effects of cyproterone acetate on the reproductive tract and pituitary-gonadal axis of the golden hamster. Andrologia. 1993 Sep-Oct;25(5):289–292. [PubMed]
  • Meriggiola MC, Bremner WJ, Costantino A, Pavani A, Capelli M, Flamigni C. An oral regimen of cyproterone acetate and testosterone undecanoate for spermatogenic suppression in men. Fertil Steril. 1997 Nov;68(5):844–850. [PubMed]
  • Loeffler IK, Peterson RE. Interactive effects of TCDD and p,p'-DDE on male reproductive tract development in in utero and lactationally exposed rats. Toxicol Appl Pharmacol. 1999 Jan 1;154(1):28–39. [PubMed]
  • Moorman WJ, Cheever KL, Skaggs SR, Clark JC, Turner TW, Marlow KL, Schrader SM. Male adolescent exposure to endocrine-disrupting pesticides: vinclozolin exposure in peripubertal rabbits. Andrologia. 2000 Sep;32(4-5):285–293. [PubMed]
  • Daniels JL, Olshan AF, Savitz DA. Pesticides and childhood cancers. Environ Health Perspect. 1997 Oct;105(10):1068–1077. [PMC free article] [PubMed]
  • Zahm SH, Ward MH. Pesticides and childhood cancer. Environ Health Perspect. 1998 Jun;106 (Suppl 3):893–908. [PMC free article] [PubMed]
  • Ward MH, Nuckols JR, Weigel SJ, Maxwell SK, Cantor KP, Miller RS. Identifying populations potentially exposed to agricultural pesticides using remote sensing and a Geographic Information System. Environ Health Perspect. 2000 Jan;108(1):5–12. [PMC free article] [PubMed]
  • Xiang H, Nuckols JR, Stallones L. A geographic information assessment of birth weight and crop production patterns around mother's residence. Environ Res. 2000 Feb;82(2):160–167. [PubMed]
  • Kettles MK, Browning SR, Prince TS, Horstman SW. Triazine herbicide exposure and breast cancer incidence: an ecologic study of Kentucky counties. Environ Health Perspect. 1997 Nov;105(11):1222–1227. [PMC free article] [PubMed]
  • Mills PK. Correlation analysis of pesticide use data and cancer incidence rates in California counties. Arch Environ Health. 1998 Nov-Dec;53(6):410–413. [PubMed]
  • Schreinemachers DM, Creason JP, Garry VF. Cancer mortality in agricultural regions of Minnesota. Environ Health Perspect. 1999 Mar;107(3):205–211. [PMC free article] [PubMed]
  • Lewis RG, Fortmann RC, Camann DE. Evaluation of methods for monitoring the potential exposure of small children to pesticides in the residential environment. Arch Environ Contam Toxicol. 1994 Jan;26(1):37–46. [PubMed]
  • Whitemore RW, Immerman FW, Camann DE, Bond AE, Lewis RG, Schaum JL. Non-occupational exposures to pesticides for residents of two U.S. cities. Arch Environ Contam Toxicol. 1994 Jan;26(1):47–59. [PubMed]
  • Cohen Hubal EA, Sheldon LS, Burke JM, McCurdy TR, Berry MR, Rigas ML, Zartarian VG, Freeman NC. Children's exposure assessment: a review of factors influencing Children's exposure, and the data available to characterize and assess that exposure. Environ Health Perspect. 2000 Jun;108(6):475–486. [PMC free article] [PubMed]
  • Zartarian VG, Ozkaynak H, Burke JM, Zufall MJ, Rigas ML, Furtaw EJ., Jr A modeling framework for estimating children's residential exposure and dose to chlorpyrifos via dermal residue contact and nondietary ingestion. Environ Health Perspect. 2000 Jun;108(6):505–514. [PMC free article] [PubMed]
  • Quackenboss JJ, Pellizzari ED, Shubat P, Whitmore RW, Adgate JL, Thomas KW, Freeman NC, Stroebel C, Lioy PJ, Clayton AC, et al. Design strategy for assessing multi-pathway exposure for children: the Minnesota Children's Pesticide Exposure Study (MNCPES). J Expo Anal Environ Epidemiol. 2000 Mar-Apr;10(2):145–158. [PubMed]
  • Simcox NJ, Fenske RA, Wolz SA, Lee IC, Kalman DA. Pesticides in household dust and soil: exposure pathways for children of agricultural families. Environ Health Perspect. 1995 Dec;103(12):1126–1134. [PMC free article] [PubMed]
  • Bradman MA, Harnly ME, Draper W, Seidel S, Teran S, Wakeham D, Neutra R. Pesticide exposures to children from California's Central Valley: results of a pilot study. J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217–234. [PubMed]
  • Loewenherz C, Fenske RA, Simcox NJ, Bellamy G, Kalman D. Biological monitoring of organophosphorus pesticide exposure among children of agricultural workers in central Washington State. Environ Health Perspect. 1997 Dec;105(12):1344–1353. [PMC free article] [PubMed]
  • Fenske RA, Kissel JC, Lu C, Kalman DA, Simcox NJ, Allen EH, Keifer MC. Biologically based pesticide dose estimates for children in an agricultural community. Environ Health Perspect. 2000 Jun;108(6):515–520. [PMC free article] [PubMed]
  • Barnard C, Daberkow S, Padgitt M, Smith ME, Uri ND. Alternative measures of pesticide use. Sci Total Environ. 1997 Sep 15;203(3):229–244. [PubMed]
  • Cochran RC, Formoli TA, Pfeifer KF, Aldous CN. Characterization of risks associated with the use of molinate. Regul Toxicol Pharmacol. 1997 Apr;25(2):146–157. [PubMed]
  • Rall DP. Can laboratory animal carcinogenicity studies predict cancer in exposed children? Environ Health Perspect. 1995 Sep;103 (Suppl 6):173–175. [PMC free article] [PubMed]
  • Chester G, Ward RJ. Occupational exposure and drift hazard during aerial application of paraquat to cotton. Arch Environ Contam Toxicol. 1984 Sep;13(5):551–563. [PubMed]
  • Kukull WA, Larson EB, Bowen JD, McCormick WC, Teri L, Pfanschmidt ML, Thompson JD, O'Meara ES, Brenner DE, van Belle G. Solvent exposure as a risk factor for Alzheimer's disease: a case-control study. Am J Epidemiol. 1995 Jun 1;141(11):1059–1079. [PubMed]
  • Needleman HL, Gunnoe C, Leviton A, Reed R, Peresie H, Maher C, Barrett P. Deficits in psychologic and classroom performance of children with elevated dentine lead levels. N Engl J Med. 1979 Mar 29;300(13):689–695. [PubMed]
  • Needleman HL, Gatsonis CA. Low-level lead exposure and the IQ of children. A meta-analysis of modern studies. JAMA. 1990 Feb 2;263(5):673–678. [PubMed]
  • Schwartz J, Angle C, Pitcher H. Relationship between childhood blood lead levels and stature. Pediatrics. 1986 Mar;77(3):281–288. [PubMed]
  • Schwartz J, Otto D. Blood lead, hearing thresholds, and neurobehavioral development in children and youth. Arch Environ Health. 1987 May-Jun;42(3):153–160. [PubMed]
  • Wasserman G, Graziano JH, Factor-Litvak P, Popovac D, Morina N, Musabegovic A, Vrenezi N, Capuni-Paracka S, Lekic V, Preteni-Redjepi E, et al. Independent effects of lead exposure and iron deficiency anemia on developmental outcome at age 2 years. J Pediatr. 1992 Nov;121(5 Pt 1):695–703. [PubMed]
  • Wasserman GA, Graziano JH, Factor-Litvak P, Popovac D, Morina N, Musabegovic A, Vrenezi N, Capuni-Paracka S, Lekic V, Preteni-Redjepi E, et al. Consequences of lead exposure and iron supplementation on childhood development at age 4 years. Neurotoxicol Teratol. 1994 May-Jun;16(3):233–240. [PubMed]
  • Pirkle JL, Brody DJ, Gunter EW, Kramer RA, Paschal DC, Flegal KM, Matte TD. The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES) JAMA. 1994 Jul 27;272(4):284–291. [PubMed]
  • Brody DJ, Pirkle JL, Kramer RA, Flegal KM, Matte TD, Gunter EW, Paschal DC. Blood lead levels in the US population. Phase 1 of the Third National Health and Nutrition Examination Survey (NHANES III, 1988 to 1991) JAMA. 1994 Jul 27;272(4):277–283. [PubMed]
  • Update: blood lead levels--United States, 1991-1994. MMWR Morb Mortal Wkly Rep. 1997 Feb 21;46(7):141–146. [PubMed]
  • Dallman PR, Yip R, Johnson C. Prevalence and causes of anemia in the United States, 1976 to 1980. Am J Clin Nutr. 1984 Mar;39(3):437–445. [PubMed]
  • Sargent JD, Stukel TA, Dalton MA, Freeman JL, Brown MJ. Iron deficiency in Massachusetts communities: Socioeconomic and demographic risk factors among children. Am J Public Health. 1996 Apr;86(4):544–550. [PMC free article] [PubMed]
  • Yip R, Dallman PR. Developmental changes in erythrocyte protoporphyrin: roles of iron deficiency and lead toxicity. J Pediatr. 1984 May;104(5):710–713. [PubMed]
  • Eden AN, Mir MA. Iron deficiency in 1- to 3-year-old children. A pediatric failure? Arch Pediatr Adolesc Med. 1997 Oct;151(10):986–988. [PubMed]
  • Six KM, Goyer RA. The influence of iron deficiency on tissue content and toxicity of ingested lead in the rat. J Lab Clin Med. 1972 Jan;79(1):128–136. [PubMed]
  • Miller GD, Massaro TF, Massaro EJ. Interactions between lead and essential elements: a review. Neurotoxicology. 1990 Spring;11(1):99–119. [PubMed]
  • Barton JC, Conrad ME, Nuby S, Harrison L. Effects of iron on the absorption and retention of lead. J Lab Clin Med. 1978 Oct;92(4):536–547. [PubMed]
  • Ragan HA. Effects of iron deficiency on the absorption and distribution of lead and cadmium in rats. J Lab Clin Med. 1977 Oct;90(4):700–706. [PubMed]
  • Flanagan PR, Hamilton DL, Haist J, Valberg LS. Interrelationships between iron and lead absorption in iron-deficient mice. Gastroenterology. 1979 Nov;77(5):1074–1081. [PubMed]
  • Conrad ME, Umbreit JN, Moore EG. A role for mucin in the absorption of inorganic iron and other metal cations. A study in rats. Gastroenterology. 1991 Jan;100(1):129–136. [PubMed]
  • Conrad ME, Umbreit JN, Moore EG, Rodning CR. Newly identified iron-binding protein in human duodenal mucosa. Blood. 1992 Jan 1;79(1):244–247. [PubMed]
  • Markowitz ME, Rosen JF, Bijur PE. Effects of iron deficiency on lead excretion in children with moderate lead intoxication. J Pediatr. 1990 Mar;116(3):360–364. [PubMed]
  • Ruff HA, Markowitz ME, Bijur PE, Rosen JF. Relationships among blood lead levels, iron deficiency, and cognitive development in two-year-old children. Environ Health Perspect. 1996 Feb;104(2):180–185. [PMC free article] [PubMed]
  • Lacey EP. Broadening the perspective of pica: literature review. Public Health Rep. 1990 Jan-Feb;105(1):29–35. [PMC free article] [PubMed]
  • Federman DG, Kirsner RS, Federman GS. Pica: are you hungry for the facts? Conn Med. 1997 Apr;61(4):207–209. [PubMed]
  • Watson WS, Hume R, Moore MR. Oral absorption of lead and iron. Lancet. 1980 Aug 2;2(8188):236–237. [PubMed]
  • Watson WS, Morrison J, Bethel MI, Baldwin NM, Lyon DT, Dobson H, Moore MR, Hume R. Food iron and lead absorption in humans. Am J Clin Nutr. 1986 Aug;44(2):248–256. [PubMed]
  • Mahaffey KR. Environmental lead toxicity: nutrition as a component of intervention. Environ Health Perspect. 1990 Nov;89:75–78. [PMC free article] [PubMed]
  • Flanagan PR, Chamberlain MJ, Valberg LS. The relationship between iron and lead absorption in humans. Am J Clin Nutr. 1982 Nov;36(5):823–829. [PubMed]
  • Yip R, Norris TN, Anderson AS. Iron status of children with elevated blood lead concentrations. J Pediatr. 1981 Jun;98(6):922–925. [PubMed]
  • Hammad TA, Sexton M, Langenberg P. Relationship between blood lead and dietary iron intake in preschool children. A cross-sectional study. Ann Epidemiol. 1996 Jan;6(1):30–33. [PubMed]
  • Wright RO, Shannon MW, Wright RJ, Hu H. Association between iron deficiency and low-level lead poisoning in an urban primary care clinic. Am J Public Health. 1999 Jul;89(7):1049–1053. [PMC free article] [PubMed]
  • Hershko C, Konijn AM, Moreb J, Link G, Grauer F, Weissenberg E. Iron depletion and blood lead levels in a population with endemic lead poisoning. Isr J Med Sci. 1984 Nov;20(11):1039–1043. [PubMed]
  • Lucas SR, Sexton M, Langenberg P. Relationship between blood lead and nutritional factors in preschool children: a cross-sectional study. Pediatrics. 1996 Jan;97(1):74–78. [PubMed]
  • Ziegler EE, Edwards BB, Jensen RL, Mahaffey KR, Fomon SJ. Absorption and retention of lead by infants. Pediatr Res. 1978 Jan;12(1):29–34. [PubMed]
  • Sutton PM, Athanasoulis M, Flessel P, Guirguis G, Haan M, Schlag R, Goldman LR. Lead levels in the household environment of children in three high-risk communities in California. Environ Res. 1995 Jan;68(1):45–57. [PubMed]
  • Siimes MA, Addiego JE, Jr, Dallman PR. Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children. Blood. 1974 Apr;43(4):581–590. [PubMed]
  • Cook JD, Skikne BS. Iron deficiency: definition and diagnosis. J Intern Med. 1989 Nov;226(5):349–355. [PubMed]
  • Dallman PR, Siimes MA, Stekel A. Iron deficiency in infancy and childhood. Am J Clin Nutr. 1980 Jan;33(1):86–118. [PubMed]
  • Deinard AS, Schwartz S, Yip R. Developmental changes in serum ferritin and erythrocyte protoporphyrin in normal (nonanemic) children. Am J Clin Nutr. 1983 Jul;38(1):71–76. [PubMed]
  • CDC criteria for anemia in children and childbearing-aged women. MMWR Morb Mortal Wkly Rep. 1989 Jun 9;38(22):400–404. [PubMed]
  • Yip R, Johnson C, Dallman PR. Age-related changes in laboratory values used in the diagnosis of anemia and iron deficiency. Am J Clin Nutr. 1984 Mar;39(3):427–436. [PubMed]
  • Madhavan S, Rosenman KD, Shehata T. Lead in soil: recommended maximum permissible levels. Environ Res. 1989 Jun;49(1):136–142. [PubMed]
  • Hsieh LL, Liou SH, Chen YH, Tsai LC, Yang T, Wu TN. Association between aminolevulinate dehydrogenase genotype and blood lead levels in Taiwan. J Occup Environ Med. 2000 Feb;42(2):151–155. [PubMed]
  • Schwartz BS, Stewart WF, Kelsey KT, Simon D, Park S, Links JM, Todd AC. Associations of tibial lead levels with BsmI polymorphisms in the vitamin D receptor in former organolead manufacturing workers. Environ Health Perspect. 2000 Mar;108(3):199–203. [PMC free article] [PubMed]
  • Wetmur JG, Lehnert G, Desnick RJ. The delta-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes. Environ Res. 1991 Dec;56(2):109–119. [PubMed]
  • Ziemsen B, Angerer J, Lehnert G, Benkmann HG, Goedde HW. Polymorphism of delta-aminolevulinic acid dehydratase in lead-exposed workers. Int Arch Occup Environ Health. 1986;58(3):245–247. [PubMed]
  • Mahaffey KR, Gartside PS, Glueck CJ. Blood lead levels and dietary calcium intake in 1- to 11-year-old children: the Second National Health and Nutrition Examination Survey, 1976 to 1980. Pediatrics. 1986 Aug;78(2):257–262. [PubMed]
  • Johnson NE, Tenuta K. Diets and lead blood levels of children who practice pica. Environ Res. 1979 Apr;18(2):369–376. [PubMed]
  • Blake KC, Mann M. Effect of calcium and phosphorus on the gastrointestinal absorption of 203Pb in man. Environ Res. 1983 Feb;30(1):188–194. [PubMed]
  • Sargent JD, Dalton MA, O'Connor GT, Olmstead EM, Klein RZ. Randomized trial of calcium glycerophosphate-supplemented infant formula to prevent lead absorption. Am J Clin Nutr. 1999 Jun;69(6):1224–1230. [PubMed]
  • Laraque D, McCormick M, Norman M, Taylor A, Weller SC, Karp J. Blood lead, calcium status, and behavior in preschool children. Am J Dis Child. 1990 Feb;144(2):186–189. [PubMed]
  • Pollitt E, Leibel RL. Iron deficiency and behavior. J Pediatr. 1976 Mar;88(3):372–381. [PubMed]
  • Lozoff B, Brittenham GM, Viteri FE, Wolf AW, Urrutia JJ. Developmental deficits in iron-deficient infants: effects of age and severity of iron lack. J Pediatr. 1982 Dec;101(6):948–952. [PubMed]
  • Idjradinata P, Pollitt E. Reversal of developmental delays in iron-deficient anaemic infants treated with iron. Lancet. 1993 Jan 2;341(8836):1–4. [PubMed]
  • Gergen PJ, Weiss KB. Changing patterns of asthma hospitalization among children: 1979 to 1987. JAMA. 1990 Oct 3;264(13):1688–1692. [PubMed]
  • Mannino DM, Homa DM, Pertowski CA, Ashizawa A, Nixon LL, Johnson CA, Ball LB, Jack E, Kang DS. Surveillance for asthma--United States, 1960-1995. MMWR CDC Surveill Summ. 1998 Apr 24;47(1):1–27. [PubMed]
  • Braun-Fahrländer C, Ackermann-Liebrich U, Schwartz J, Gnehm HP, Rutishauser M, Wanner HU. Air pollution and respiratory symptoms in preschool children. Am Rev Respir Dis. 1992 Jan;145(1):42–47. [PubMed]
  • Martinez FD, Cline M, Burrows B. Increased incidence of asthma in children of smoking mothers. Pediatrics. 1992 Jan;89(1):21–26. [PubMed]
  • Busse WW, Gern JE, Dick EC. The role of respiratory viruses in asthma. Ciba Found Symp. 1997;206:208–219. [PubMed]
  • Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990 Aug 23;323(8):502–507. [PubMed]
  • Weiss KB, Gergen PJ, Crain EF. Inner-city asthma. The epidemiology of an emerging US public health concern. Chest. 1992 Jun;101(6 Suppl):362S–367S. [PubMed]
  • Adler NE, Boyce T, Chesney MA, Cohen S, Folkman S, Kahn RL, Syme SL. Socioeconomic status and health. The challenge of the gradient. Am Psychol. 1994 Jan;49(1):15–24. [PubMed]
  • Rabkin JG, Struening EL. Live events, stress, and illness. Science. 1976 Dec 3;194(4269):1013–1020. [PubMed]
  • Taylor SE, Repetti RL, Seeman T. Health psychology: what is an unhealthy environment and how does it get under the skin? Annu Rev Psychol. 1997;48:411–447. [PubMed]
  • Taylor L, Zuckerman B, Harik V, Groves BM. Witnessing violence by young children and their mothers. J Dev Behav Pediatr. 1994 Apr;15(2):120–123. [PubMed]
  • Sheehan K, DiCara JA, LeBailly S, Christoffel KK. Children's exposure to violence in an urban setting. Arch Pediatr Adolesc Med. 1997 May;151(5):502–504. [PubMed]
  • Osofsky JD, Wewers S, Hann DM, Fick AC. Chronic community violence: what is happening to our children? Psychiatry. 1993 Feb;56(1):36–45. [PubMed]
  • Herman AA. Political violence, health, and health services in South Africa. Am J Public Health. 1988 Jul;78(7):767–768. [PMC free article] [PubMed]
  • Zapata BC, Rebolledo A, Atalah E, Newman B, King MC. The influence of social and political violence on the risk of pregnancy complications. Am J Public Health. 1992 May;82(5):685–690. [PMC free article] [PubMed]
  • Pike JL, Smith TL, Hauger RL, Nicassio PM, Patterson TL, McClintick J, Costlow C, Irwin MR. Chronic life stress alters sympathetic, neuroendocrine, and immune responsivity to an acute psychological stressor in humans. Psychosom Med. 1997 Jul-Aug;59(4):447–457. [PubMed]
  • Baum A. Stress, intrusive imagery, and chronic distress. Health Psychol. 1990;9(6):653–675. [PubMed]
  • Fitzpatrick KM, Boldizar JP. The prevalence and consequences of exposure to violence among African-American youth. J Am Acad Child Adolesc Psychiatry. 1993 Mar;32(2):424–430. [PubMed]
  • McEwen BS, Biron CA, Brunson KW, Bulloch K, Chambers WH, Dhabhar FS, Goldfarb RH, Kitson RP, Miller AH, Spencer RL, et al. The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Res Brain Res Rev. 1997 Feb;23(1-2):79–133. [PubMed]
  • Brosschot JF, Benschop RJ, Godaert GL, Olff M, De Smet M, Heijnen CJ, Ballieux RE. Influence of life stress on immunological reactivity to mild psychological stress. Psychosom Med. 1994 May-Jun;56(3):216–224. [PubMed]
  • Sternberg EM. Neural-immune interactions in health and disease. J Clin Invest. 1997 Dec 1;100(11):2641–2647. [PMC free article] [PubMed]
  • Busse WW, Kiecolt-Glaser JK, Coe C, Martin RJ, Weiss ST, Parker SR. NHLBI Workshop summary. Stress and asthma. Am J Respir Crit Care Med. 1995 Jan;151(1):249–252. [PubMed]
  • Wright RJ, Rodriguez M, Cohen S. Review of psychosocial stress and asthma: an integrated biopsychosocial approach. Thorax. 1998 Dec;53(12):1066–1074. [PMC free article] [PubMed]
  • Gellhorn E. The neurophysiological basis of anxiety: a hypothesis. Perspect Biol Med. 1965 Summer;8(4):488–515. [PubMed]
  • Vingerhoets AJ. The role of the parasympathetic division of the autonomic nervous system in stress and the emotions. Int J Psychosom. 1985;32(3):28–34. [PubMed]
  • Nadel JA, Barnes PJ. Autonomic regulation of the airways. Annu Rev Med. 1984;35:451–467. [PubMed]
  • Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med. 1991 Aug 29;325(9):606–612. [PubMed]
  • Graham NM, Douglas RM, Ryan P. Stress and acute respiratory infection. Am J Epidemiol. 1986 Sep;124(3):389–401. [PubMed]
  • Donovan CE, Finn PW. Immune mechanisms of childhood asthma. Thorax. 1999 Oct;54(10):938–946. [PMC free article] [PubMed]
  • Beckham JC, Roodman AA, Shipley RH, Hertzberg MA, Cunha GH, Kudler HS, Levin ED, Rose JE, Fairbank JA. Smoking in Vietnam combat veterans with post-traumatic stress disorder. J Trauma Stress. 1995 Jul;8(3):461–472. [PubMed]
  • Acierno RA, Kilpatrick DG, Resnick HS, Saunders BE, Best CL. Violent assault, posttraumatic stress disorder, and depression. Risk factors for cigarette use among adult women. Behav Modif. 1996 Oct;20(4):363–384. [PubMed]
  • Reijneveld SA. The impact of individual and area characteristics on urban socioeconomic differences in health and smoking. Int J Epidemiol. 1998 Feb;27(1):33–40. [PubMed]
  • Feigelman W, Gorman B. Toward explaining the higher incidence of cigarette smoking among black Americans. J Psychoactive Drugs. 1989 Jul-Sep;21(3):299–305. [PubMed]
  • Romano PS, Bloom J, Syme SL. Smoking, social support, and hassles in an urban African-American community. Am J Public Health. 1991 Nov;81(11):1415–1422. [PMC free article] [PubMed]
  • Stenius-Aarniala B, Poussa T, Kvarnström J, Grönlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ. 2000 Mar 25;320(7238):827–832. [PMC free article] [PubMed]
  • Gortmaker SL, Must A, Sobol AM, Peterson K, Colditz GA, Dietz WH. Television viewing as a cause of increasing obesity among children in the United States, 1986-1990. Arch Pediatr Adolesc Med. 1996 Apr;150(4):356–362. [PubMed]
  • Krause N. Stress and isolation from close ties in later life. J Gerontol. 1991 Jul;46(4):S183–S194. [PubMed]
  • Fong RL. Violence as a barrier to compliance for the hypertensive urban African American. J Natl Med Assoc. 1995 Mar;87(3):203–207. [PMC free article] [PubMed]
  • Fleming AW, Sterling-Scott RP, Carabello G, Imari-Williams I, Allmond B, Foster RS, Kennedy F, Shoemaker WC. Injury and violence in Los Angeles. Impact on access to health care and surgical education. Arch Surg. 1992 Jun;127(6):671–676. [PubMed]
  • Robicsek F, Ribbeck B, Walker LG, Thomason MH, Hollenbeck JI, Baker JW. The cost of violence. The economy of health care delivery for non-accidental trauma in an urban southeastern community. N C Med J. 1993 Nov;54(11):578–582. [PubMed]
  • Gustafsson PA, Kjellman NI, Ludvigsson J, Cederblad M. Asthma and family interaction. Arch Dis Child. 1987 Mar;62(3):258–263. [PMC free article] [PubMed]
  • Boxer GH, Carson J, Miller BD. Neglect contributing to tertiary hospitalization in childhood asthma. Child Abuse Negl. 1988;12(4):491–501. [PubMed]
  • Strunk RC, Mrazek DA, Fuhrmann GS, LaBrecque JF. Physiologic and psychological characteristics associated with deaths due to asthma in childhood. A case-controlled study. JAMA. 1985 Sep 6;254(9):1193–1198. [PubMed]
  • Kauffman KS. Center as haven: findings of an urban ethnography. Nurs Res. 1995 Jul-Aug;44(4):231–236. [PubMed]
  • Stringham P. Violence anticipatory guidance. Pediatr Clin North Am. 1998 Apr;45(2):439–448. [PubMed]
  • Sampson RJ, Raudenbush SW, Earls F. Neighborhoods and violent crime: a multilevel study of collective efficacy. Science. 1997 Aug 15;277(5328):918–924. [PubMed]
  • Kawachi I, Kennedy BP, Wilkinson RG. Crime: social disorganization and relative deprivation. Soc Sci Med. 1999 Mar;48(6):719–731. [PubMed]
  • Wallace D, Wallace R. Scales of geography, time, and population: the study of violence as a public health problem. Am J Public Health. 1998 Dec;88(12):1853–1858. [PMC free article] [PubMed]
  • Kawachi I, Kennedy BP. Income inequality and health: pathways and mechanisms. Health Serv Res. 1999 Apr;34(1 Pt 2):215–227. [PMC free article] [PubMed]

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