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Environ Health Perspect. 2002 Jan; 110(1): A8–10.
PMCID: PMC1240702
Research Article

The National Center for Toxicogenomics: using new technologies to inform mechanistic toxicology.

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Selected References

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  • Iannaccone PM. Toxicogenomics: "the call of the wild chip". Environ Health Perspect. 2001 Jan;109(1):A8–11. [PMC free article] [PubMed]
  • Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science. 1995 Oct 20;270(5235):467–470. [PubMed]
  • Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H, et al. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol. 1996 Dec;14(13):1675–1680. [PubMed]
  • Brown PO, Botstein D. Exploring the new world of the genome with DNA microarrays. Nat Genet. 1999 Jan;21(1 Suppl):33–37. [PubMed]
  • Afshari CA, Nuwaysir EF, Barrett JC. Application of complementary DNA microarray technology to carcinogen identification, toxicology, and drug safety evaluation. Cancer Res. 1999 Oct 1;59(19):4759–4760. [PubMed]
  • Olden K, Guthrie J. Genomics: implications for toxicology. Mutat Res. 2001 Jan 25;473(1):3–10. [PubMed]
  • Hamadeh HK, Bushel P, Paules R, Afshari CA. Discovery in toxicology: mediation by gene expression array technology. J Biochem Mol Toxicol. 2001;15(5):231–242. [PubMed]
  • Lobenhofer EK, Bushel PR, Afshari CA, Hamadeh HK. Progress in the application of DNA microarrays. Environ Health Perspect. 2001 Sep;109(9):881–891. [PMC free article] [PubMed]
  • Fielden MR, Zacharewski TR. Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicol Sci. 2001 Mar;60(1):6–10. [PubMed]
  • Smith LL. Key challenges for toxicologists in the 21st century. Trends Pharmacol Sci. 2001 Jun;22(6):281–285. [PubMed]
  • Bartosiewicz MJ, Jenkins D, Penn S, Emery J, Buckpitt A. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. J Pharmacol Exp Ther. 2001 Jun;297(3):895–905. [PubMed]
  • Bulera SJ, Eddy SM, Ferguson E, Jatkoe TA, Reindel JF, Bleavins MR, De La Iglesia FA. RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays. Hepatology. 2001 May;33(5):1239–1258. [PubMed]
  • Bessems JG, Vermeulen NP. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit Rev Toxicol. 2001 Jan;31(1):55–138. [PubMed]
  • Wilkins MR, Pasquali C, Appel RD, Ou K, Golaz O, Sanchez JC, Yan JX, Gooley AA, Hughes G, Humphery-Smith I, et al. From proteins to proteomes: large scale protein identification by two-dimensional electrophoresis and amino acid analysis. Biotechnology (N Y) 1996 Jan;14(1):61–65. [PubMed]
  • Rubin RB, Merchant M. A rapid protein profiling system that speeds study of cancer and other diseases. Am Clin Lab. 2000 Sep-Oct;19(8):28–29. [PubMed]
  • Merchant M, Weinberger SR. Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry. Electrophoresis. 2000 Apr;21(6):1164–1177. [PubMed]
  • Li X, Mohan S, Gu W, Miyakoshi N, Baylink DJ. Differential protein profile in the ear-punched tissue of regeneration and non-regeneration strains of mice: a novel approach to explore the candidate genes for soft-tissue regeneration. Biochim Biophys Acta. 2000 Dec 15;1524(2-3):102–109. [PubMed]
  • Borrebaeck CA. Antibodies in diagnostics - from immunoassays to protein chips. Immunol Today. 2000 Aug;21(8):379–382. [PubMed]
  • Liotta L, Petricoin E. Molecular profiling of human cancer. Nat Rev Genet. 2000 Oct;1(1):48–56. [PubMed]
  • Huang RP. Detection of multiple proteins in an antibody-based protein microarray system. J Immunol Methods. 2001 Sep 1;255(1-2):1–13. [PubMed]
  • Lueking A, Horn M, Eickhoff H, Büssow K, Lehrach H, Walter G. Protein microarrays for gene expression and antibody screening. Anal Biochem. 1999 May 15;270(1):103–111. [PubMed]
  • Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999 Nov;29(11):1181–1189. [PubMed]
  • Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863–14868. [PMC free article] [PubMed]
  • Ermolaeva O, Rastogi M, Pruitt KD, Schuler GD, Bittner ML, Chen Y, Simon R, Meltzer P, Trent JM, Boguski MS. Data management and analysis for gene expression arrays. Nat Genet. 1998 Sep;20(1):19–23. [PubMed]
  • Tamayo P, Slonim D, Mesirov J, Zhu Q, Kitareewan S, Dmitrovsky E, Lander ES, Golub TR. Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2907–2912. [PMC free article] [PubMed]
  • Quackenbush J. Computational analysis of microarray data. Nat Rev Genet. 2001 Jun;2(6):418–427. [PubMed]

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