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Biochem J. Feb 15, 2004; 378(Pt 1): 213–217.
PMCID: PMC1223940

Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition.


The mechanisms regulating mitochondrial outer-membrane permeabilization and the release of cytochrome c during apoptosis remain controversial. In the present study, we show in an in vitro model system that the release of cytochrome c may occur via moderate modulation of mitochondrial volume, irrespective of the mechanism leading to the mitochondrial swelling. In contrast with mitochondrial permeability transition-dependent release of cytochrome c, in the present study mitochondria remain intact and functionally active.

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Selected References

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