• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Dec 1980; 96(4): 819–839.
PMCID: PMC1219303

The Origin of Spontaneous Mutation in SACCHAROMYCES CEREVISIAE


Characterization of two antimutator loci in yeast shows that both are members of the same mutagenic repair system known to be responsible for almost all induced mutation (Lawrence and Christensen 1976, 1979a,b; Prakash 1976). One of the these newly isolated antimutator mutations is an allele of rev3 (Lemontt 1971b). Two other alleles of rev3 were tested and were also found to be antimutators. Double mutants carrying rev3 and mutator mutations of rad3, rad51 or rad18 are like rev3 single mutants with respect to spontaneous mutation rate, supporting the hypothesis (Hastings, Quah and von Borstel 1976) that many mutators in yeast act by channelling spontaneous lesions from accurate to mutagenic repair. However, the enhanced mutation rate seen in a radiation-resistant mutator mutant mut1 is not dependent on REV3, but is dependent on another gene designated ANT1. An additive effect on the reduction in spontaneous mutation, seen in the ant1 rev3 double-mutant strain, leads to the conclusion that at least 90% of spontaneous mutations seen in the wild type are caused by mutagenic repair of spontaneous lesions.

Full Text

The Full Text of this article is available as a PDF (1.0M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Postel M, Genet JP, Mathieu M. L'arthroplastie du genou Total Condylar. Chirurgie. 1981 Apr-May;107(5):375–378. [PubMed]
  • Lindegren G, Hwang YL, Oshima Y, Lindegren CC. Genetical mutants induced by ethyl methanesulfonate in Saccharomyces. Can J Genet Cytol. 1965 Sep;7(3):491–499. [PubMed]
  • McKee RH, Lawrence CW. Genetic analysis of gamma-ray mutagenesis in yeast. I. Reversion in radiation-sensitive strains. Genetics. 1979 Oct;93(2):361–373. [PMC free article] [PubMed]
  • Morrison DP, Hastings PJ. Characterization of the mutator mutation mut5-1. Mol Gen Genet. 1979 Aug;175(1):57–65. [PubMed]
  • Moustacchi E. Cytoplasmic and nuclear genetic events induced by UV light in strains of Saccharomyces cerevisiae with different UV sensitivities. Mutat Res. 1969 Mar-Apr;7(2):171–185. [PubMed]
  • Prakash L. Effect of Genes Controlling Radiation Sensitivity on Chemically Induced Mutations in SACCHAROMYCES CEREVISIAE. Genetics. 1976 Jun;83(2):285–301. [PMC free article] [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...