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Br Heart J. Dec 1989; 62(6): 462–466.
PMCID: PMC1216789

Cardiac involvement in Churg-Strauss syndrome shown by echocardiography.


To define the range of cardiac involvement in the Churg-Strauss syndrome, M mode, continuous wave Doppler, and cross sectional echocardiograms were recorded in twelve patients with the disorder. The M mode recordings were digitised and the cross sectional images were recorded with standardised gain settings to determine regional myocardial echo amplitude. Left ventricular end diastolic and end systolic dimensions were increased above the normal 95% confidence interval in four patients, three of whom showed a depressed shortening fraction. Mitral regurgitation was present in six patients; this was severe enough to need valve replacement in two. Mean echo amplitude in both the septum and the posterior wall was significantly increased above normal by a mean (SD) of 4.87 (2.57) dB, suggesting the presence of myocardial fibrosis. There was no evidence of subendocardial involvement as there is in other hypereosinophilic syndromes. Mitral regurgitation is common in the Churg-Strauss syndrome. This cannot be ascribed to involvement of the cusps or chordae and it occurs even when ventricular function is well preserved. It is suggested that mitral regurgitation is caused by diffuse myocardial fibrosis.

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Selected References

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  • Chumbley LC, Harrison EG, Jr, DeRemee RA. Allergic granulomatosis and angiitis (Churg-Strauss syndrome). Report and analysis of 30 cases. Mayo Clin Proc. 1977 Aug;52(8):477–484. [PubMed]
  • Lanham JG, Elkon KB, Pusey CD, Hughes GR. Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome. Medicine (Baltimore) 1984 Mar;63(2):65–81. [PubMed]
  • Oakley CM, Olsen GJ. Eosinophilia and heart disease. Br Heart J. 1977 Mar;39(3):233–237. [PMC free article] [PubMed]
  • Logan-Sinclair R, Wong CM, Gibson DG. Clinical application of amplitude processing of echocardiographic images. Br Heart J. 1981 Jun;45(6):621–627. [PMC free article] [PubMed]
  • Upton MT, Gibson DG. The study of left ventricular function from digitized echocardiograms. Prog Cardiovasc Dis. 1978 Mar-Apr;20(5):359–384. [PubMed]
  • Bradley JA, Gibson DG. Assessment of the severity of mitral regurgitation from the dynamics of retrograde flow. Br Heart J. 1988 Aug;60(2):134–140. [PMC free article] [PubMed]
  • Roberts WC, Liegler DG, Carbone PP. Endomyocardial disease and eosinophilia. A clinical and pathologic spectrum. Am J Med. 1969 Jan;46(1):28–42. [PubMed]
  • Olsen EG, Spry CJ. Relation between eosinophilia and endomyocardial disease. Prog Cardiovasc Dis. 1985 Jan-Feb;27(4):241–254. [PubMed]
  • Chusid MJ, Dale DC, West BC, Wolff SM. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 1975 Jan;54(1):1–27. [PubMed]
  • Roberts WC, Buja LM, Ferrans VJ. Löffler's fibroplastic parietal endocarditis, eosinophilic leukemia, and Davies' endomyocardial fibrosis: the same disease at different stages? Pathol Microbiol (Basel) 1970;35(1):90–95. [PubMed]
  • Chew CY, Ziady GM, Raphael MJ, Nellen M, Oakley CM. Primary restrictive cardiomyopathy. Non-tropical endomyocardial fibrosis and hypereosinophilic heart disease. Br Heart J. 1977 Apr;39(4):399–413. [PMC free article] [PubMed]
  • Spry CJ, Take M, Tai PC. Eosinophilic disorders affecting the myocardium and endocardium: a review. Heart Vessels Suppl. 1985;1:240–242. [PubMed]
  • Rosenberg TF, Medsger TA, Jr, DeCicco FA, Fireman P. Allergic granulomatous angiitis (Churg-Strauss syndrome). J Allergy Clin Immunol. 1975 Jan;55(1):56–67. [PubMed]
  • Davison AG, Thompson PJ, Davies J, Corrin B, Turner-Warwick M. Prominent pericardial and myocardial lesions in the Churg-Strauss syndrome (allergic granulomatosis and angiitis). Thorax. 1983 Oct;38(10):793–795. [PMC free article] [PubMed]
  • Shaw TR, Logan-Sinclair RB, Surin C, McAnulty RJ, Heard B, Laurent GJ, Gibson DG. Relation between regional echo intensity and myocardial connective tissue in chronic left ventricular disease. Br Heart J. 1984 Jan;51(1):46–53. [PMC free article] [PubMed]
  • Vijayaraghavan G, Davies J, Sadanandan S, Spry CJ, Gibson DG, Goodwin JF. Echocardiographic features of tropical endomyocardial disease in South India. Br Heart J. 1983 Nov;50(5):450–459. [PMC free article] [PubMed]
  • Davies J, Gibson DG, Foale R, Heer K, Spry CJ, Oakley CM, Goodwin JF. Echocardiographic features of eosinophilic endomyocardial disease. Br Heart J. 1982 Nov;48(5):434–440. [PMC free article] [PubMed]

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