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Genetics. 1979 Dec; 93(4): 861–875.
PMCID: PMC1214118

Vegetative Incompatibility and the Mating-Type Locus in the Cellular Slime Mold DICTYOSTELIUM DISCOIDEUM


The genetic basis of vegetative incompatibility in the cellular slime mold, Dictyostelium discoideum, is elucidated. Vegetatively compatible haploid strains from parasexual diploids at a frequency of between 10-6 and 10-5, whereas "escaped" diploids are formed between vegetatively incompatible strains at a frequency of ∼10-8. There is probably only a single vegetative incompatibility site, which appears to be located at, or closely linked to, the mating-type locus. The nature of the vegetative incompatibility is deduced from parasexual diploid formation between wild isolates and tester strains of each mating type, examination of the frequency of formation of "escaped" diploids formed between vegetatively incompatible strains, and examination of the mating type and vegetative incompatibility of haploid segregants obtained from "escaped" diploids.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Clark MA, Francis D, Eisenberg R. Mating types in cellular slime molds. Biochem Biophys Res Commun. 1973 May 15;52(2):672–678. [PubMed]
  • Erdos GW, Raper KB, Vogen LK. Mating Types and Macrocyst Formation in Dictyostelium discoideum. Proc Natl Acad Sci U S A. 1973 Jun;70(6):1828–1830. [PMC free article] [PubMed]
  • Filosa MF, Dengler RE. Ultrastructure of macrocyst formation in the cellular slime mold, Dictyostelium mucoroides: extensive phagocytosis of amoebae by a specialized cell. Dev Biol. 1972 Sep;29(1):1–16. [PubMed]
  • Free SJ, Schimke RT. The structural gene for alpha-mannosidase-1 in Dictyostellium discoideum. Genetics. 1976 Oct;84(2):159–174. [PMC free article] [PubMed]
  • Garnjobst L, Wilson JF. HETEROCARYOSIS AND PROTOPLASMIC INCOMPATIBILITY IN NEUROSPORA CRASSA. Proc Natl Acad Sci U S A. 1956 Sep;42(9):613–618. [PMC free article] [PubMed]
  • Klein J. Many questions (and almost no answers) about the phylogenetic origin of the major histocompatibility complex. Adv Exp Med Biol. 1975;64:467–478. [PubMed]
  • Newell PC. Genetics of the cellular slime molds. Annu Rev Genet. 1978;12:69–93. [PubMed]
  • Newmeyer D. A suppressor of the heterokaryon-incompatibility associated with mating type in Neurospora crassa. Can J Genet Cytol. 1970 Dec;12(4):914–926. [PubMed]
  • PONTECORVO G, KAFER E. Genetic analysis based on mitotic recombination. Adv Genet. 1958;9:71–104. [PubMed]
  • Wallace MA, Raper KB. Genetic exchanges in the macrocysts of Dictyostelium discoideum. J Gen Microbiol. 1979 Aug;113(2):327–337. [PubMed]
  • Williams KL. Isolation of strains of the cellular slime mold Dictyostelium discoideum capable of growing after a single passage in axenic medium. Appl Environ Microbiol. 1976 Oct;32(4):635–637. [PMC free article] [PubMed]

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