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Genetics. Oct 1979; 93(2): 375–381.
PMCID: PMC1214085

Genetic Analysis of Gamma-Ray Mutagenesis in Yeast. II. Allele-Specific Control of Mutagenesis


We find that partially different sets of gene functions are required for the production of different kinds of mutations induced by 60Co γ rays in Saccharomyces cerevisiae. This observation is very similar to others made previously with respect to UV mutagenesis (Lawrence and Christensen 1978a,b, 1979) and confirms the conclusion that such distinctive patterns of genetic control reflect properties of the test alleles and their genetic locations, rather than the kinds of lesions required to revert them. The data also support the model of mutagenic repair outlined in the first paper of this series (McKee and Lawrence 1979), in which partially different sets of gene functions are required for the production of different kinds of mutations, the formation of mutations at different genetic sites and the induction of mutations by different mutagens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Lawrence CW, Christensen R. UV mutagenesis in radiation-sensitive strains of yeast. Genetics. 1976 Feb;82(2):207–232. [PMC free article] [PubMed]
  • McKee RH, Lawrence CW. Genetic analysis of gamma-ray mutagenesis in yeast. I. Reversion in radiation-sensitive strains. Genetics. 1979 Oct;93(2):361–373. [PMC free article] [PubMed]

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