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Genetics. Oct 1979; 93(2): 361–373.
PMCID: PMC1214084

Genetic Analysis of Gamma-Ray Mutagenesis in Yeast. I. Reversion in Radiation-Sensitive Strains


The frequency of revertants induced by 60Co γ rays of the ochre allele, cyc1-9, has been measured in radiation-sensitive strains carrying one of 19 nonallelic mutations and in wild-type strains. The results indicate that ionizing radiation mutagenesis depends on the activity of the RAD6 group of genes and that the gene functions employed are very similar, but probably not identical, to those that mediate UV mutagenesis. Repair activities dependent on the functions of the RAD50 through RAD57 loci, the major pathway for the repair of damage caused by ionizing radiation, do not appear to play any part in mutagenesis. A comparison between the γ-ray data and those obtained previously with UV (Lawrence and Christensen 1976) and chemical mutagens (Prakash 1976) suggests that the RAD6 "mutagenic pathway" is in fact composed of a set of processes, some of which are concerned with error-prone, and some with error-free, recovery activities.

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Selected References

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  • Lawrence CW, Stewart JW, Sherman F, Christensen R. Specificity and frequency of ultraviolet-induced reversion of an iso-1-cytochrome c ochre mutant in radiation-sensitive strains of yeast. J Mol Biol. 1974 May 5;85(1):137–162. [PubMed]
  • Resnick MA. Genetic control of radiation sensitivity in Saccharomyces cerevisiae. Genetics. 1969 Jul;62(3):519–531. [PMC free article] [PubMed]

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