• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Oct 1978; 90(2): 277–289.
PMCID: PMC1213889

Homoeosis in Drosophila. II. a Genetic Analysis of Polycomb

Abstract

Three dominant mutant alleles of the Polycomb locus of Drosophila melanogaster are associated with homoeotic transformations of meso- and metathoracic to prothoracic legs, a homoeotic transformation of antennae to legs, and abnormalities of wings and some thoracic bristles. Puro and Nygrén (1975) localized Polycomb in the proximal left arm of chromosome 3 within salivary gland chromosome interval 77E,F-80. In the present study, the location and dosage relationships of this locus were examined, using translocation-generated segmental aneuploidy. The results indicate that Polycomb lies within interval 78C,D-79D, and that the locus is haplo-insufficient. Males hypoploid for this interval show meso- and metathoracic leg transformations, and both males and females show wing abnormalities. In addition, the legs of hypoploids of both sexes are shorter than those of wild-type flies, and show aberrancies of segmentation, chaetal number and distribution, and other morphological characteristics. Hypoploid flies do not express a homoeotic antennal-leg transformation, but the deficiency is associated with a Minute phenotype that is known to suppress this transformation in Polycomb flies; thus it cannot be ascertained whether the antennal-leg transformation is a haplo-insufficient phenotype. It is suggested that the expression of non-homoeotic pleiotropic effects provides a criterion for identifying homoeotic mutations that do not function directly in the establishment of determined states, but rather cause homoeosis indirectly. Polycomb is interpreted in this fashion, and it is suggested that the mutant syndrome may result from localized cell death.

Full Text

The Full Text of this article is available as a PDF (1001K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Shearn A, Hersperger G, Hersperger E. Genetic analysis of two allelic temperature-sensitive mutants of Drosophila melanogaster both of which are zygotic and maternal-effect lethals. Genetics. 1978 Jun;89(2):341–353. [PMC free article] [PubMed]
  • Capdevila MP, Garcia-Bellido A. Development and genetic analysis of bithorax phenocopies in Drosophila. Nature. 1974 Aug 9;250(5466):500–502. [PubMed]
  • Denell RE. The nature of reversion of a dominant gene of Drosophila melanogaster. Mutat Res. 1972 Jun;15(2):221–223. [PubMed]
  • Duncan IW, Kaufman TC. Cytogenic analysis of chromosome 3 in Drosophila melanogaster: mapping of the proximal portion of the right arm. Genetics. 1975 Aug;80(4):733–752. [PMC free article] [PubMed]
  • Hochman B. Analysis of chromosome 4 in Drosophila melanogaster. II. Ethyl methanesulfonate induced lethals. Genetics. 1971 Feb;67(2):235–252. [PMC free article] [PubMed]
  • Lindsley DL, Sandler L, Baker BS, Carpenter AT, Denell RE, Hall JC, Jacobs PA, Miklos GL, Davis BK, Gethmann RC, et al. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics. 1972 May;71(1):157–184. [PMC free article] [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...