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Genetics. May 1974; 77(1): 71–94.
PMCID: PMC1213120



Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.

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Selected References

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  • Dion M, Brun JL. Cartographie génique du nématode libre Caenorhabditis elegans, Maupas 1900, variété Bergerac. I. Etude de deux mutants nains. Mol Gen Genet. 1971;112(2):133–151. [PubMed]
  • Sulston JE, Brenner S. The DNA of Caenorhabditis elegans. Genetics. 1974 May;77(1):95–104. [PMC free article] [PubMed]
  • Thienpont D, Vanparijs OF, Raeymaekers AH, Vandenberk J, Demoen JA, Allewijn FT, Marsboom RP, Niemegeers CJ, Schellekens KH, Janssen PA. Tetramisole (R 8299), a new, potent broad spectrum anthelmintic. Nature. 1966 Mar 12;209(5028):1084–1086. [PubMed]

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