• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Feb 1974; 76(2): 327–338.
PMCID: PMC1213069

Population Studies in Microorganisms I. Evolution of Diploidy in SACCHAROMYCES CEREVISIAE

Abstract

The relative adaptation of isogenic haploid and diploid strains of yeast was investigated in different sets of physiological conditions. When all nutrients were present in excess, no difference in the reproductive rates of isogenic haploid and diploid strains of yeast was detected in both optimal and non-optimal growth conditions. Competition between haploid and diploid strains of yeast was observed when growth was limited by the concentration of a single nutrilite. Under certain conditions when fitness (reproductive rate) is determined by transport of an essential nutrilite that exists in very low concentrations, diploid cells were selected against. These environmental conditions are similar to those found in offshore marine environments where nutrients are often present in extremely low concentrations. The fitness of diploid cells was estimated to be.93 ±.02 (haploid fitness = 1). The reduced fitness of diploid cells in this environment can be explained by the reduced surface area/volume ratio possessed by diploid cells in comparison to haploid cells. The fitnesses of haploid and diploid cells in these environments are closely correlated with geometric variations in these strains. These results are consistent with the hypothesis that diploid cells are simply double haploids, and diploidy per se does not confer any direct adaptive advantage. The mechanism of the evolution of diploidy as a dominant phase in the life cycle of higher plants and animals remains obscure.

Full Text

The Full Text of this article is available as a PDF (833K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ciferri O, Sora S, Tiboni O. Effect of gene dosage on tryptophan synthetase activity in Saccharomyces cerevisiae. Genetics. 1969 Mar;61(3):567–576. [PMC free article] [PubMed]
  • Francis JC, Hansche PE. Directed evolution of metabolic pathways in microbial populations. I. Modification of the acid phosphatase pH optimum in S. cerevisiae. Genetics. 1972 Jan;70(1):59–73. [PMC free article] [PubMed]
  • HERBERT D, ELSWORTH R, TELLING RC. The continuous culture of bacteria; a theoretical and experimental study. J Gen Microbiol. 1956 Jul;14(3):601–622. [PubMed]
  • LACROUTE F. R'EGULATION DES ENZYMES DE BIOSYNTH'ESE DE L'URACILE CHEZ LA LEVURE. C R Hebd Seances Acad Sci. 1964 Mar 9;258:2884–2886. [PubMed]
  • MORTIMER RK. Radiobiological and genetic studies on a polyploid series (haploid to hexaploid) of Saccharomyces cerevisiae. Radiat Res. 1958 Sep;9(3):312–326. [PubMed]
  • Nitsch JP, Nitsch C. Haploid plants from pollen grains. Science. 1969 Jan 3;163(3862):85–87. [PubMed]
  • OGUR M, MINCKLER S, LINDEGREN G, LINDEGREN CC. The nucleic acids in a polyploid series of Saccharomyces. Arch Biochem Biophys. 1952 Sep;40(1):175–184. [PubMed]
  • Roman H, Phillips MM, Sands SM. Studies of Polyploid Saccharomyces. I. Tetraploid Segregation. Genetics. 1955 Jul;40(4):546–561. [PMC free article] [PubMed]
  • Schweizer E, Halvorson HO. On the regulation of ribosomal RNA synthesis in yeast. Exp Cell Res. 1969 Aug;56(2):239–244. [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...