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Genetics. Mar 1973; 73(3): 513–530.
PMCID: PMC1212910

Effects of Population Size and Selection Intensity on Short-Term Response to Selection for Postweaning Gain in Mice

Abstract

The effects of population size and selection intensity on the mean response was examined after 14 generations of within full-sib family selection for postweaning gain in mice. Population sizes of 1, 2, 4, 8 and 16 pair matings were each evaluated at selection intensities of 100% (control), 50% and 25% in a replicated experiment. Selection response per generation increased as selection intensity increased. Selection response and realized heritability tended to increase with increasing population size. Replicate variability in realized heritability was large at population sizes of 1, 2 and 4 pairs. Genetic drift was implicated as the primary factor causing the reduced response and lowered repeatability at the smaller population sizes. Lines with intended effective population sizes of 62 yielded larger selection responses per unit selection differential than lines with effective population sizes of 30 or less.

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Selected References

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  • Chung CS, Chapman AB. Comparisons of the Predicted with Actual Gains from Selection of Parents of Inbred Progeny of Rats. Genetics. 1958 May;43(3):594–600. [PMC free article] [PubMed]

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