• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Oct 1972; 72(2): 335–355.
PMCID: PMC1212831

Mutation Rate and Dominance of Genes Affecting Viability in DROSOPHILA MELANOGASTER

Abstract

Spontaneous mutations were allowed to accumulate in a second chromosome that was transmitted only through heterozygous males for 40 generations. At 10-generation intervals the chromosomes were assayed for homozygous effects of the accumulated mutants. From the regression of homozygous viability on the number of generations of mutant accumulation and from the increase in genetic variance between replicate chromosomes it is possible to estimate the mutation rate and average effect of the individual mutants. Lethal mutations arose at a rate of 0.0060 per chromosome per generation. The mutants having small effects on viability are estimated to arise with a frequency at least 10 times as high as lethals, more likely 20 times as high, and possibly many more times as high if there is a large class of very nearly neutral mutations.—The dominance of such mutants was measured for chromosomes extracted from a natural population. This was determined from the regression of heterozygous viability on that of the sum of the two constituent homozygotes. The average dominance for minor viability genes in an equilibrium population was estimated to be 0.21. This is lower than the value for new mutants, as expected since those with the greatest heterozygous effect are most quickly eliminated from the population. That these mutants have a disproportionately large heterozygous effect on total fitness (as well as on the viability component thereof) is shown by the low ratio of the genetic load in equilibrium homozygotes to that of new mutant homozygotes.

Full Text

The Full Text of this article is available as a PDF (1.1M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Hiraizumi Y, Crow JF. Heterozygous Effects on Viability, Fertility, Rate of Development, and Longevity of Drosophila Chromosomes That Are Lethal When Homozygous. Genetics. 1960 Aug;45(8):1071–1083. [PMC free article] [PubMed]
  • Morton NE, Chung CS, Friedman LD, Morton NT, Miki C, Yee S. Relation between homozygous viability and average dominance in Drosophila melanogaster. Genetics. 1968 Nov;60(3):601–614. [PMC free article] [PubMed]
  • Morton NE, Crow JF, Muller HJ. AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES. Proc Natl Acad Sci U S A. 1956 Nov;42(11):855–863. [PMC free article] [PubMed]
  • MUKAI T. THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. I. SPONTANEOUS MUTATION RATE OF POLYGENES CONTROLLING VIABILITY. Genetics. 1964 Jul;50:1–19. [PMC free article] [PubMed]
  • Mukai T, Yamazaki T. The genetic structure of natural populations of Drosophila melanogaster. V. Coupling-repulsion effect of spontaneous mutant polygenes controlling viability. Genetics. 1968 Aug;59(4):513–535. [PMC free article] [PubMed]
  • PAXMAN GJ. A study of spontaneous mutation in Drosophila melanogaster. Genetica. 1958;29(1-2):39–57. [PubMed]
  • Temin RG. Homozygous viability and fertility loads in Drosophila melanogaster. Genetics. 1966 Jan;53(1):27–46. [PMC free article] [PubMed]
  • Temin RG, Meyer HU, Dawson PS, Crow JF. The influence of epistasis on homozygous viability depression in Drosophila melanogaster. Genetics. 1969 Feb;61(2):497–519. [PMC free article] [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...