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Genetics. Apr 1996; 142(4): 1299–1304.
PMCID: PMC1207126

Transmission-Ratio Distortion through F(1) Females at Chromosome 11 Loci Linked to Om in the Mouse Ddk Syndrome

Abstract

We determined the genotypes of >200 offspring that are survivors of matings between female reciprocal F(1) hybrids (between the DDK and C57BL/6J inbred mouse strains) and C57BL/6J males at markers linked to the Ovum mutant (Om) locus on chromosome 11. In contrast to the expectations of our previous genetic model to explain the ``DDK syndrome,'' the genotypes of these offspring do not reflect preferential survival of individuals that receive C57BL/6J alleles from the F(1) females in the region of chromosome 11 to which the Om locus has been mapped. In fact, we observe significant transmission-ratio distortion in favor of DDK alleles in this region. These results are also in contrast to the expectations of Wakasugi's genetic model for the inheritance of Om, in which he proposed equal transmission of DDK and non-DDK alleles from F(1) females. We propose that the results of these experiments may be explained by reduced expression of the maternal DDK Om allele or expression of the maternal DDK Om allele in only a portion of the ova of F(1) females.

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Selected References

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  • Baldacci PA, Richoux V, Renard JP, Guénet JL, Babinet C. The locus Om, responsible for the DDK syndrome, maps close to Sigje on mouse chromosome 11. Mamm Genome. 1992;2(2):100–105. [PubMed]
  • Copeland NG, Jenkins NA, Gilbert DJ, Eppig JT, Maltais LJ, Miller JC, Dietrich WF, Weaver A, Lincoln SE, Steen RG, et al. A genetic linkage map of the mouse: current applications and future prospects. Science. 1993 Oct 1;262(5130):57–66. [PubMed]
  • Chess A, Simon I, Cedar H, Axel R. Allelic inactivation regulates olfactory receptor gene expression. Cell. 1994 Sep 9;78(5):823–834. [PubMed]
  • Dietrich WF, Miller JC, Steen RG, Merchant M, Damron D, Nahf R, Gross A, Joyce DC, Wessel M, Dredge RD, et al. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nat Genet. 1994 Jun;7(2 Spec No):220–245. [PubMed]
  • Feil R, Baldacci PA, Tarttelin E, Rhodes M, Singh PB, Reik W. Cbx-rs2 (M31), a mouse homolog of the Drosophila Heterochromatin protein 1 gene, maps to distal chromosome 11 and is nonallelic to Om. Mamm Genome. 1995 Jul;6(7):469–471. [PubMed]
  • Frankel WN, Stoye JP, Taylor BA, Coffin JM. A linkage map of endogenous murine leukemia proviruses. Genetics. 1990 Feb;124(2):221–236. [PMC free article] [PubMed]
  • Hearne CM, McAleer MA, Love JM, Aitman TJ, Cornall RJ, Ghosh S, Knight AM, Prins JB, Todd JA. Additional microsatellite markers for mouse genome mapping. Mamm Genome. 1991;1(4):273–282. [PubMed]
  • Love JM, Knight AM, McAleer MA, Todd JA. Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites. Nucleic Acids Res. 1990 Jul 25;18(14):4123–4130. [PMC free article] [PubMed]
  • Mann JR. DDK egg-foreign sperm incompatibility in mice is not between the pronuclei. J Reprod Fertil. 1986 Mar;76(2):779–781. [PubMed]
  • Montagutelli X, Serikawa T, Guénet JL. PCR-analyzed microsatellites: data concerning laboratory and wild-derived mouse inbred strains. Mamm Genome. 1991;1(4):255–259. [PubMed]
  • Nehls M, Lüno K, Schorpp M, Pfeifer D, Krause S, Matysiak-Scholze U, Dierbach H, Boehm T. YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11. Mamm Genome. 1995 May;6(5):321–331. [PubMed]
  • Renard JP, Babinet C. Identification of a paternal developmental effect on the cytoplasm of one-cell-stage mouse embryos. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6883–6886. [PMC free article] [PubMed]
  • Renard JP, Baldacci P, Richoux-Duranthon V, Pournin S, Babinet C. A maternal factor affecting mouse blastocyst formation. Development. 1994 Apr;120(4):797–802. [PubMed]
  • Sapienza C, Paquette J, Pannunzio P, Albrechtson S, Morgan K. The polar-lethal Ovum mutant gene maps to the distal portion of mouse chromosome 11. Genetics. 1992 Sep;132(1):241–246. [PMC free article] [PubMed]
  • Wakasugi N. Studies on fertility of DDK mice: reciprocal crosses between DDK and C57BL/6J strains and experimental transplantation of the ovary. J Reprod Fertil. 1973 May;33(2):283–291. [PubMed]
  • Wakasugi N. A genetically determined incompatibility system between spermatozoa and eggs leading to embryonic death in mice. J Reprod Fertil. 1974 Nov;41(1):85–96. [PubMed]
  • Wakasugi N, Morita M. Studies on the development of F1 embryos from inter-strain cross involving DDK mice. J Embryol Exp Morphol. 1977 Apr;38:211–216. [PubMed]
  • Wakasugi N, Tomita T, Kondo K. Differences of fertility in reciprocal crosses between inbred strains of mice. DDK, KK and NC. J Reprod Fertil. 1967 Feb;13(1):41–50. [PubMed]

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