• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Feb 1995; 139(2): 1031–1044.
PMCID: PMC1206354

Modeling Interference in Genetic Recombination


In analyzing genetic linkage data it is common to assume that the locations of crossovers along a chromosome follow a Poisson process, whereas it has long been known that this assumption does not fit the data. In many organisms it appears that the presence of a crossover inhibits the formation of another nearby, a phenomenon known as ``interference.'' We discuss several point process models for recombination that incorporate position interference but assume no chromatid interference. Using stochastic simulation, we are able to fit the models to a multilocus Drosophila dataset by the method of maximum likelihood. We find that some biologically inspired point process models incorporating one or two additional parameters provide a dramatically better fit to the data than the usual ``no-interference'' Poisson model.

Full Text

The Full Text of this article is available as a PDF (2.6M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • CARTER TC, ROBERTSON A. A mathematical treatment of genetical recombination using a four-strand model. Proc R Soc Lond B Biol Sci. 1952 Apr 24;139(896):410–426. [PubMed]
  • Cobbs G. Renewal process approach to the theory of genetic linkage: case of no chromatid interference. Genetics. 1978 Jul;89(3):563–581. [PMC free article] [PubMed]
  • Foss E, Lande R, Stahl FW, Steinberg CM. Chiasma interference as a function of genetic distance. Genetics. 1993 Mar;133(3):681–691. [PMC free article] [PubMed]
  • Goldgar DE, Fain PR. Models of multilocus recombination: nonrandomness in chiasma number and crossover positions. Am J Hum Genet. 1988 Jul;43(1):38–45. [PMC free article] [PubMed]
  • Liberman U, Karlin S. Theoretical models of genetic map functions. Theor Popul Biol. 1984 Jun;25(3):331–346. [PubMed]
  • OWEN ARG. The theory of genetical recombination. Adv Genet. 1950;3:117–157. [PubMed]
  • Pascoe L, Morton NE. The use of map functions in multipoint mapping. Am J Hum Genet. 1987 Feb;40(2):174–183. [PMC free article] [PubMed]
  • Risch N, Lange K. An alternative model of recombination and interference. Ann Hum Genet. 1979 Jul;43(1):61–70. [PubMed]
  • Risch N, Lange K. Statistical analysis of multilocus recombination. Biometrics. 1983 Dec;39(4):949–963. [PubMed]
  • Speed TP, McPeek MS, Evans SN. Robustness of the no-interference model for ordering genetic markers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3103–3106. [PMC free article] [PubMed]
  • Stam P. Interference in Genetic Crossing over and Chromosome Mapping. Genetics. 1979 Jun;92(2):573–594. [PMC free article] [PubMed]
  • Weinstein A. The Theory of Multiple-Strand Crossing over. Genetics. 1936 May;21(3):155–199. [PMC free article] [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...