Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Apr 1994; 136(4): 1261–1269.
PMCID: PMC1205906

Genetic Characterization of Pathogenic Saccharomyces Cerevisiae Isolates


Saccharomyces cerevisiae isolates from human patients have been genetically analyzed. Some of the characteristics of these isolates are very different from laboratory and industrial strains of S. cerevisiae and, for this reason, stringent genetic tests have been used to confirm their identity as S. cerevisiae. Most of these clinical isolates are able to grow at 42°, a temperature that completely inhibits the growth of most other S. cerevisiae strains. This property can be considered a virulence trait and may help explain the presence of these isolates in human hosts. The ability to grow at 42° is shown to be polygenic with primarily additive effects between loci. S. cerevisiae will be a useful model for the evolution and genetic analysis of fungal virulence and the study of polygenic traits.

Full Text

The Full Text of this article is available as a PDF (1.9M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Aucott JN, Fayen J, Grossnicklas H, Morrissey A, Lederman MM, Salata RA. Invasive infection with Saccharomyces cerevisiae: report of three cases and review. Rev Infect Dis. 1990 May-Jun;12(3):406–411. [PubMed]
  • Chattoo BB, Sherman F, Azubalis DA, Fjellstedt TA, Mehnert D, Ogur M. Selection of lys2 Mutants of the Yeast SACCHAROMYCES CEREVISIAE by the Utilization of alpha-AMINOADIPATE. Genetics. 1979 Sep;93(1):51–65. [PMC free article] [PubMed]
  • Cimolai N, Gill MJ, Church D. Saccharomyces cerevisiae fungemia: case report and review of the literature. Diagn Microbiol Infect Dis. 1987 Oct;8(2):113–117. [PubMed]
  • Dougherty SH, Simmons RL. Postoperative peritonitis caused by Saccharomyces cerevisiae. Arch Surg. 1982 Feb;117(2):248–248. [PubMed]
  • Eng RH, Drehmel R, Smith SM, Goldstein EJ. Saccharomyces cerevisiae infections in man. Sabouraudia. 1984;22(5):403–407. [PubMed]
  • Eschete ML, West BC. Saccharomyces cerevisiae septicemia. Arch Intern Med. 1980 Nov;140(11):1539–1539. [PubMed]
  • Kamiyama A, Niimi M, Tokunaga M, Nakayama H. Adansonian study of Candida albicans: intraspecific homogeneity excepting C. stellatoidea strains. J Med Vet Mycol. 1989;27(4):229–241. [PubMed]
  • Manzella JP, Shaffer S, Agarwal N, Kellogg JA. Saccharomyces cerevisiae fungemia in a multiply traumatized patient. J Trauma. 1989 Jan;29(1):129–130. [PubMed]
  • McCusker JH, Haber JE. Cycloheximide-resistant temperature-sensitive lethal mutations of Saccharomyces cerevisiae. Genetics. 1988 Jun;119(2):303–315. [PMC free article] [PubMed]
  • Medoff G, Maresca B, Lambowitz AM, Kobayashi G, Painter A, Sacco M, Carratu L. Correlation between pathogenicity and temperature sensitivity in different strains of Histoplasma capsulatum. J Clin Invest. 1986 Dec;78(6):1638–1647. [PMC free article] [PubMed]
  • Mortimer RK, Schild D. Genetic map of Saccharomyces cerevisiae. Microbiol Rev. 1980 Dec;44(4):519–571. [PMC free article] [PubMed]
  • Nielsen H, Stenderup J, Bruun B. Fungemia with Saccharomycetaceae. Report of four cases and review of the literature. Scand J Infect Dis. 1990;22(5):581–584. [PubMed]
  • Perkins DD. Biochemical Mutants in the Smut Fungus Ustilago Maydis. Genetics. 1949 Sep;34(5):607–626. [PMC free article] [PubMed]
  • Scherer S, Magee PT. Genetics of Candida albicans. Microbiol Rev. 1990 Sep;54(3):226–241. [PMC free article] [PubMed]
  • Sethi N, Mandell W. Saccharomyces fungemia in a patient with AIDS. N Y State J Med. 1988 May;88(5):278–279. [PubMed]
  • Tawfik OW, Papasian CJ, Dixon AY, Potter LM. Saccharomyces cerevisiae pneumonia in a patient with acquired immune deficiency syndrome. J Clin Microbiol. 1989 Jul;27(7):1689–1691. [PMC free article] [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...