Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. 1991 Aug; 128(4): 813–821.
PMCID: PMC1204554

Interspecific Backcross Mice Show Sex-Specific Differences in Allelic Inheritance


Transmission distortion is identified as a difference in transmission frequency of two alleles from the normal 1:1 Mendelian segregation in diploid organisms. Transmission distortion can extend over part or all of a chromosome. The recent development of interspecific mouse backcrosses has provided a powerful method for multilocus mapping of entire chromosomes in a single cross, and consequently for identifying distortions in allelic inheritance. We used an interspecific backcross of [(C57BL/6J X Mus spretus)F(1) X C57BL/6J] mice to map molecular loci to mouse chromosome 2 and had previously found that the distal region of the chromosome showed distortions in allelic inheritance. We now report the mapping of five loci (Actc-1, D2Hgu1, His-1, Hox-4.1 and Neb) to chromosome 2, which, in addition to the Abl, Ada, B2m, Bmp-2a, Hc, Emv-15, Fshb, Hck-1, Pax-1, Pck-1, Spna-2 and Vim loci previously mapped in our interspecific backcross, serve as markers to measure allelic inheritance along ~75% of mouse chromosome 2. Statistical analyses are used to identify and delimit chromosomal regions showing transmission distortion and to determine whether there are sex-specific differences in allelic inheritance. These studies provide evidence for sex-specific differences in allelic inheritance for chromosome 2 and suggest biological explanations for this form of transmission distortion.

Full Text

The Full Text of this article is available as a PDF (921K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Avner P, Amar L, Dandolo L, Guénet JL. Genetic analysis of the mouse using interspecific crosses. Trends Genet. 1988 Jan;4(1):18–23. [PubMed]
  • Bickmore W, Christie S, van Heyningen V, Hastie ND, Porteous DJ. Hitch-hiking from HRAS1 to the WAGR locus with CMGT markers. Nucleic Acids Res. 1988 Jan 11;16(1):51–60. [PMC free article] [PubMed]
  • Biddle FG. Segregation distortion of X-linked marker genes in interspecific crosses between Mus musculus and M. spretus. Genome. 1987 Apr;29(2):389–392. [PubMed]
  • Bonhomme F, Catalan J, Britton-Davidian J, Chapman VM, Moriwaki K, Nevo E, Thaler L. Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275–303. [PubMed]
  • Crosby JL, Phillips SJ, Nadeau JH. The cardiac actin locus (Actc-1) is not on mouse chromosome 17 but is linked to beta 2-microglobulin on chromosome 2. Genomics. 1989 Jul;5(1):19–23. [PubMed]
  • Guénet JL. The contribution of wild derived mouse inbred strains to gene mapping methodology. Curr Top Microbiol Immunol. 1986;127:109–113. [PubMed]
  • Justice MJ, Siracusa LD, Gilbert DJ, Heisterkamp N, Groffen J, Chada K, Silan CM, Copeland NG, Jenkins NA. A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross. Genetics. 1990 Aug;125(4):855–866. [PMC free article] [PubMed]
  • Kitzis A, Chomel JC, Haliassos A, Tesson L, Kaplan JC, Feingold J, Giraud G, Lable A, Dastugue B, Dumur V, et al. Unusual segregation of cystic fibrosis alleles. Nature. 1988 Nov 24;336(6197):316–316. [PubMed]
  • Lonai P, Arman E, Czosnek H, Ruddle FH, Blatt C. New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409–418. [PubMed]
  • Mattei MG, Lilienbaum A, Lin LZ, Mattei JF, Paulin D. Chromosomal localization of the mouse gene coding for vimentin. Genet Res. 1989 Jun;53(3):183–185. [PubMed]
  • Seldin MF, Howard TA, D'Eustachio P. Comparison of linkage maps of mouse chromosome 12 derived from laboratory strain intraspecific and Mus spretus interspecific backcrosses. Genomics. 1989 Jul;5(1):24–28. [PubMed]
  • Siracusa LD, Buchberg AM, Copeland NG, Jenkins NA. Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus. Genetics. 1989 Jul;122(3):669–679. [PMC free article] [PubMed]
  • Siracusa LD, Silan CM, Justice MJ, Mercer JA, Bauskin AR, Ben-Neriah Y, Duboule D, Hastie ND, Copeland NG, Jenkins NA. A molecular genetic linkage map of mouse chromosome 2. Genomics. 1990 Mar;6(3):491–504. [PubMed]
  • Zeviani M, Darras BT, Rizzuto R, Salviati G, Betto R, Bonilla E, Miranda AF, Du J, Samitt C, Dickson G, et al. Cloning and expression of human nebulin cDNAs and assignment of the gene to chromosome 2q31-q32. Genomics. 1988 Apr;2(3):249–256. [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...