• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Sep 1989; 123(1): 229–240.
PMCID: PMC1203786

DNA Polymorphism in a Subdivided Population: The Expected Number of Segregating Sites in the Two-Subpopulation Model

Abstract

Using the two subpopulation model, the expected numbers of segregating sites in a number of DNA sequences randomly sampled from a subdivided population were examined for several types of population subdivisions. It is shown that, in the case where the pattern of migration is symmetrical such as the finite island model, the expected number of segregating sites is independent of the migration rate when two or three DNA sequences are randomly sampled from the same subpopulation, but depends on the migration rate when more than three DNA sequences are sampled. It is also shown that the population subdivision can increase the amount of DNA polymorphism even in a subpopulation in some cases.

Full Text

The Full Text of this article is available as a PDF (1.5M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Griffiths RC. Lines of descent in the diffusion approximation of neutral Wright-Fisher models. Theor Popul Biol. 1980 Feb;17(1):37–50. [PubMed]
  • Kimura M. Evolutionary rate at the molecular level. Nature. 1968 Feb 17;217(5129):624–626. [PubMed]
  • Kimura M. The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations. Genetics. 1969 Apr;61(4):893–903. [PMC free article] [PubMed]
  • Kimura M, Weiss GH. The Stepping Stone Model of Population Structure and the Decrease of Genetic Correlation with Distance. Genetics. 1964 Apr;49(4):561–576. [PMC free article] [PubMed]
  • Latter BD. The island model of population differentiation: a general solution. Genetics. 1973 Jan;73(1):147–157. [PMC free article] [PubMed]
  • Li WH. Distribution of nucleotide differences between two randomly chosen cistrons in a subdivided population: the finite island model. Theor Popul Biol. 1976 Dec;10(3):303–308. [PubMed]
  • Li WH, Nei M. Drift variances of heterozygosity and genetic distance in transient states. Genet Res. 1975 Jun;25(3):229–248. [PubMed]
  • Li WH, Nei M. Persistence of common alleles in two related populations or species. Genetics. 1977 Aug;86(4):901–914. [PMC free article] [PubMed]
  • Maruyama T. Effective number of alleles in a subdivided population. Theor Popul Biol. 1970 Nov;1(3):273–306. [PubMed]
  • Nei M, Feldman MW. Identity of genes by descent within and between populations under mutation and migration pressures. Theor Popul Biol. 1972 Dec;3(4):460–465. [PubMed]
  • Slatkin M. The average number of sites separating DNA sequences drawn from a subdivided population. Theor Popul Biol. 1987 Aug;32(1):42–49. [PubMed]
  • Strobeck C. Average number of nucleotide differences in a sample from a single subpopulation: a test for population subdivision. Genetics. 1987 Sep;117(1):149–153. [PMC free article] [PubMed]
  • Tajima F. Evolutionary relationship of DNA sequences in finite populations. Genetics. 1983 Oct;105(2):437–460. [PMC free article] [PubMed]
  • Watterson GA. On the number of segregating sites in genetical models without recombination. Theor Popul Biol. 1975 Apr;7(2):256–276. [PubMed]
  • Wright S. Evolution in Mendelian Populations. Genetics. 1931 Mar;16(2):97–159. [PMC free article] [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...