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Genetics. Sep 1989; 123(1): 109–121.
PMCID: PMC1203774

The Multivulva Phenotype of Certain Caenorhabditis Elegans Mutants Results from Defects in Two Functionally Redundant Pathways


We previously identified Caenorhabditis elegans mutants in which certain of the six vulval precursor cells adopt fates normally expressed by other vulval precursor cells. These mutants define genes that appear to function in the response to an intercellular signal that induces vulval development. The multivulva (Muv) phenotype of one such mutant, CB1322, results from an interaction between two unlinked mutations, lin-8(n111) II and lin-9(n112) III. In this paper, we identify 18 new mutations, which are alleles of eight genes, that interact with either lin-8(n111) or lin-9(n112) to generate a Muv phenotype. None of these 20 mutations alone causes any vulval cell lineage defects. The ``silent Muv'' mutations fall into two classes; hermaphrodites carrying a mutation of each class are Muv, while hermaphrodites carrying two mutations of the same class have a wild-type vulval phenotype. Our results indicate that the Muv phenotype of these mutants results from defects in two functionally-redundant pathways, thereby demonstrating that redundancy can occur at the level of gene pathways as well as at the level of gene families.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bullerjahn AM, Riddle DL. Fine-structure genetics of ama-1, an essential gene encoding the amanitin-binding subunit of RNA polymerase II in Caenorhabditis elegans. Genetics. 1988 Oct;120(2):423–434. [PMC free article] [PubMed]
  • Ferguson EL, Horvitz HR. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics. 1985 May;110(1):17–72. [PMC free article] [PubMed]
  • Ferguson EL, Sternberg PW, Horvitz HR. A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans. Nature. 1987 Mar 19;326(6110):259–267. [PubMed]
  • Golden JW, Riddle DL. A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci U S A. 1984 Feb;81(3):819–823. [PMC free article] [PubMed]
  • Greenwald IS, Horvitz HR. unc-93(e1500): A behavioral mutant of Caenorhabditis elegans that defines a gene with a wild-type null phenotype. Genetics. 1980 Sep;96(1):147–164. [PMC free article] [PubMed]
  • Herman RK. Crossover suppressors and balanced recessive lethals in Caenorhabditis elegans. Genetics. 1978 Jan;88(1):49–65. [PMC free article] [PubMed]
  • Horvitz HR, Brenner S, Hodgkin J, Herman RK. A uniform genetic nomenclature for the nematode Caenorhabditis elegans. Mol Gen Genet. 1979 Sep;175(2):129–133. [PubMed]
  • Kataoka T, Powers S, McGill C, Fasano O, Strathern J, Broach J, Wigler M. Genetic analysis of yeast RAS1 and RAS2 genes. Cell. 1984 Jun;37(2):437–445. [PubMed]
  • Kimble J. Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans. Dev Biol. 1981 Oct 30;87(2):286–300. [PubMed]
  • Kimble J, Hirsh D. The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans. Dev Biol. 1979 Jun;70(2):396–417. [PubMed]
  • Moerman DG, Baillie DL. Genetic Organization in CAENORHABDITIS ELEGANS: Fine-Structure Analysis of the unc-22 Gene. Genetics. 1979 Jan;91(1):95–103. [PMC free article] [PubMed]
  • Rogalski TM, Baillie DL. Genetic organization of the unc-22 IV gene and the adjacent region in Caenorhabditis elegans. Mol Gen Genet. 1985;201(3):409–414. [PubMed]
  • Rose AM, Baillie DL. Genetic organization of the region around UNC-15 (I), a gene affecting paramyosin in Caenorhabditis elegans. Genetics. 1980 Nov;96(3):639–648. [PMC free article] [PubMed]
  • Rykowski MC, Wallis JW, Choe J, Grunstein M. Histone H2B subtypes are dispensable during the yeast cell cycle. Cell. 1981 Aug;25(2):477–487. [PubMed]
  • Sternberg PW. Lateral inhibition during vulval induction in Caenorhabditis elegans. Nature. 1988 Oct 6;335(6190):551–554. [PubMed]
  • Sternberg PW, Horvitz HR. Pattern formation during vulval development in C. elegans. Cell. 1986 Mar 14;44(5):761–772. [PubMed]
  • Sulston JE, Albertson DG, Thomson JN. The Caenorhabditis elegans male: postembryonic development of nongonadal structures. Dev Biol. 1980 Aug;78(2):542–576. [PubMed]
  • Sulston JE, Horvitz HR. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol. 1977 Mar;56(1):110–156. [PubMed]
  • Sulston JE, Horvitz HR. Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans. Dev Biol. 1981 Feb;82(1):41–55. [PubMed]
  • Sulston JE, White JG. Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans. Dev Biol. 1980 Aug;78(2):577–597. [PubMed]
  • Trent C, Tsuing N, Horvitz HR. Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics. 1983 Aug;104(4):619–647. [PMC free article] [PubMed]
  • Wills N, Gesteland RF, Karn J, Barnett L, Bolten S, Waterston RH. The genes sup-7 X and sup-5 III of C. elegans suppress amber nonsense mutations via altered transfer RNA. Cell. 1983 Jun;33(2):575–583. [PubMed]
  • Waterston RH, Smith KC, Moerman DG. Genetic fine structure analysis of the myosin heavy chain gene unc-54 of Caenorhabditis elegans. J Mol Biol. 1982 Jun 15;158(1):1–15. [PubMed]

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