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Genetics. Feb 1989; 121(2): 333–352.
PMCID: PMC1203621

Zygotic Lethals with Specific Maternal Effect Phenotypes in Drosophila Melanogaster. I. Loci on the X Chromosome

Abstract

In order to identify all X-linked zygotic lethal loci that exhibit a specific maternal effect on embryonic development, germline clonal analyses of X-linked zygotic lethal mutations have been performed. Two strategies were employed. In Screen A germline clonal analysis of 441 mutations at 211 previously mapped X-linked loci within defined regions was performed. In Screen B germline clonal analysis of 581 larval and pupal mutations distributed throughout the entire length of the X chromosome was performed. These approaches provide an 86% level of saturation for X-linked late zygotic lethals (larval and pupal) with specific maternal effect embryonic lethal phenotypes. The maternal effect phenotypes of these mutations are described.

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Selected References

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  • Akam M. The molecular basis for metameric pattern in the Drosophila embryo. Development. 1987 Sep;101(1):1–22. [PubMed]
  • Baker NE. Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos. EMBO J. 1987 Jun;6(6):1765–1773. [PMC free article] [PubMed]
  • Busson D, Gans M, Komitopoulou K, Masson M. Genetic Analysis of Three Dominant Female-Sterile Mutations Located on the X Chromosome of DROSOPHILA MELANOGASTER. Genetics. 1983 Oct;105(2):309–325. [PMC free article] [PubMed]
  • Cabrera CV, Alonso MC, Johnston P, Phillips RG, Lawrence PA. Phenocopies induced with antisense RNA identify the wingless gene. Cell. 1987 Aug 14;50(4):659–663. [PubMed]
  • Degelmann A, Hardy PA, Perrimon N, Mahowald AP. Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal-effect locus. Dev Biol. 1986 Jun;115(2):479–489. [PubMed]
  • Dietrich U, Campos-Ortega JA. The expression of neurogenic loci in imaginal epidermal cells of Drosophila melanogaster. J Neurogenet. 1984 Dec;1(4):315–332. [PubMed]
  • Doe CQ, Scott MP. Segmentation and homeotic gene function in the developing nervous system of Drosophila. Trends Neurosci. 1988 Mar;11(3):101–106. [PubMed]
  • Gans M, Audit C, Masson M. Isolation and characterization of sex-linked female-sterile mutants in Drosophila melanogaster. Genetics. 1975 Dec;81(4):683–704. [PMC free article] [PubMed]
  • Garcia-Bellido A, Robbins LG. Viability of Female Germ-Line Cells Homozygous for Zygotic Lethals in DROSOPHILA MELANOGASTER. Genetics. 1983 Feb;103(2):235–247. [PMC free article] [PubMed]
  • Gerttula S, Jin YS, Anderson KV. Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation. Genetics. 1988 May;119(1):123–133. [PMC free article] [PubMed]
  • Haenlin M, Steller H, Pirrotta V, Mohier E. A 43 kilobase cosmid P transposon rescues the fs(1)K10 morphogenetic locus and three adjacent Drosophila developmental mutants. Cell. 1985 Apr;40(4):827–837. [PubMed]
  • Komitopoulou K, Gans M, Margaritis LH, Kafatos FC, Masson M. Isolation and Characterization of Sex-Linked Female-Sterile Mutants in DROSOPHILA MELANOGASTER with Special Attention to Eggshell Mutants. Genetics. 1983 Dec;105(4):897–920. [PMC free article] [PubMed]
  • Konrad KD, Engstrom L, Perrimon N, Mahowald AP. Genetic analysis of oogenesis and the role of maternal gene expression in early development. Dev Biol (N Y 1985) 1985;1:577–617. [PubMed]
  • LaBonne SG, Mahowald AP. Partial rescue of embryos from two maternal-effect neurogenic mutants by transplantation of wild-type ooplasm. Dev Biol. 1985 Jul;110(1):264–267. [PubMed]
  • Lefevre G, Watkins W. The question of the total gene number in Drosophila melanogaster. Genetics. 1986 Aug;113(4):869–895. [PMC free article] [PubMed]
  • MacKrell AJ, Blumberg B, Haynes SR, Fessler JH. The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits. Proc Natl Acad Sci U S A. 1988 Apr;85(8):2633–2637. [PMC free article] [PubMed]
  • Mohler JD. Developmental genetics of the Drosophila egg. I. Identification of 59 sex-linked cistrons with maternal effects on embryonic development. Genetics. 1977 Feb;85(2):259–272. [PMC free article] [PubMed]
  • Mortin MA, Perrimon N, Bonner JJ. Clonal analysis of two mutations in the large subunit of RNA polymerase II of Drosophila. Mol Gen Genet. 1985;199(3):421–426. [PubMed]
  • Nüsslein-Volhard C, Frohnhöfer HG, Lehmann R. Determination of anteroposterior polarity in Drosophila. Science. 1987 Dec 18;238(4834):1675–1681. [PubMed]
  • Papkoff J, Brown AM, Varmus HE. The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway. Mol Cell Biol. 1987 Nov;7(11):3978–3984. [PMC free article] [PubMed]
  • Perrimon N. Clonal Analysis of Dominant Female-Sterile, Germline-Dependent Mutations in DROSOPHILA MELANOGASTER. Genetics. 1984 Dec;108(4):927–939. [PMC free article] [PubMed]
  • Perrimon N, Gans M. Clonal analysis of the tissue specificity of recessive female-sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation Fs(1)K1237. Dev Biol. 1983 Dec;100(2):365–373. [PubMed]
  • Perrimon N, Mahowald AP. Multiple functions of segment polarity genes in Drosophila. Dev Biol. 1987 Feb;119(2):587–600. [PubMed]
  • Perrimon N, Engstrom L, Mahowald AP. The effects of zygotic lethal mutations on female germ-line functions in Drosophila. Dev Biol. 1984 Oct;105(2):404–414. [PubMed]
  • Perrimon N, Engstrom L, Mahowald AP. Developmental genetics of the 2C-D region of the Drosophila X chromosome. Genetics. 1985 Sep;111(1):23–41. [PMC free article] [PubMed]
  • Perrimon N, Smouse D, Miklos GL. Developmental genetics of loci at the base of the X chromosome of Drosophila melanogaster. Genetics. 1989 Feb;121(2):313–331. [PMC free article] [PubMed]
  • Perrimon N, Mohler D, Engstrom L, Mahowald AP. X-linked female-sterile loci in Drosophila melanogaster. Genetics. 1986 Jul;113(3):695–712. [PMC free article] [PubMed]
  • Rijsewijk F, Schuermann M, Wagenaar E, Parren P, Weigel D, Nusse R. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell. 1987 Aug 14;50(4):649–657. [PubMed]
  • Shannon MP, Kaufman TC, Shen MW, Judd BH. Lethality patterns and morphology of selected lethal and semi-lethal mutations in the zeste-white region of Drosophila melanogaster. Genetics. 1972 Dec;72(4):615–638. [PMC free article] [PubMed]
  • Simpson P. Maternal-Zygotic Gene Interactions during Formation of the Dorsoventral Pattern in Drosophila Embryos. Genetics. 1983 Nov;105(3):615–632. [PMC free article] [PubMed]
  • Wright TR. The genetics of embryogenesis in Drosophila. Adv Genet. 1970;15:261–395. [PubMed]

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