• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Feb 1989; 121(2): 333–352.
PMCID: PMC1203621

Zygotic Lethals with Specific Maternal Effect Phenotypes in Drosophila Melanogaster. I. Loci on the X Chromosome


In order to identify all X-linked zygotic lethal loci that exhibit a specific maternal effect on embryonic development, germline clonal analyses of X-linked zygotic lethal mutations have been performed. Two strategies were employed. In Screen A germline clonal analysis of 441 mutations at 211 previously mapped X-linked loci within defined regions was performed. In Screen B germline clonal analysis of 581 larval and pupal mutations distributed throughout the entire length of the X chromosome was performed. These approaches provide an 86% level of saturation for X-linked late zygotic lethals (larval and pupal) with specific maternal effect embryonic lethal phenotypes. The maternal effect phenotypes of these mutations are described.

Full Text

The Full Text of this article is available as a PDF (3.6M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Akam M. The molecular basis for metameric pattern in the Drosophila embryo. Development. 1987 Sep;101(1):1–22. [PubMed]
  • Baker NE. Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos. EMBO J. 1987 Jun;6(6):1765–1773. [PMC free article] [PubMed]
  • Busson D, Gans M, Komitopoulou K, Masson M. Genetic Analysis of Three Dominant Female-Sterile Mutations Located on the X Chromosome of DROSOPHILA MELANOGASTER. Genetics. 1983 Oct;105(2):309–325. [PMC free article] [PubMed]
  • Cabrera CV, Alonso MC, Johnston P, Phillips RG, Lawrence PA. Phenocopies induced with antisense RNA identify the wingless gene. Cell. 1987 Aug 14;50(4):659–663. [PubMed]
  • Degelmann A, Hardy PA, Perrimon N, Mahowald AP. Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal-effect locus. Dev Biol. 1986 Jun;115(2):479–489. [PubMed]
  • Dietrich U, Campos-Ortega JA. The expression of neurogenic loci in imaginal epidermal cells of Drosophila melanogaster. J Neurogenet. 1984 Dec;1(4):315–332. [PubMed]
  • Doe CQ, Scott MP. Segmentation and homeotic gene function in the developing nervous system of Drosophila. Trends Neurosci. 1988 Mar;11(3):101–106. [PubMed]
  • Gans M, Audit C, Masson M. Isolation and characterization of sex-linked female-sterile mutants in Drosophila melanogaster. Genetics. 1975 Dec;81(4):683–704. [PMC free article] [PubMed]
  • Garcia-Bellido A, Robbins LG. Viability of Female Germ-Line Cells Homozygous for Zygotic Lethals in DROSOPHILA MELANOGASTER. Genetics. 1983 Feb;103(2):235–247. [PMC free article] [PubMed]
  • Gerttula S, Jin YS, Anderson KV. Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation. Genetics. 1988 May;119(1):123–133. [PMC free article] [PubMed]
  • Haenlin M, Steller H, Pirrotta V, Mohier E. A 43 kilobase cosmid P transposon rescues the fs(1)K10 morphogenetic locus and three adjacent Drosophila developmental mutants. Cell. 1985 Apr;40(4):827–837. [PubMed]
  • Komitopoulou K, Gans M, Margaritis LH, Kafatos FC, Masson M. Isolation and Characterization of Sex-Linked Female-Sterile Mutants in DROSOPHILA MELANOGASTER with Special Attention to Eggshell Mutants. Genetics. 1983 Dec;105(4):897–920. [PMC free article] [PubMed]
  • Konrad KD, Engstrom L, Perrimon N, Mahowald AP. Genetic analysis of oogenesis and the role of maternal gene expression in early development. Dev Biol (N Y 1985) 1985;1:577–617. [PubMed]
  • LaBonne SG, Mahowald AP. Partial rescue of embryos from two maternal-effect neurogenic mutants by transplantation of wild-type ooplasm. Dev Biol. 1985 Jul;110(1):264–267. [PubMed]
  • Lefevre G, Watkins W. The question of the total gene number in Drosophila melanogaster. Genetics. 1986 Aug;113(4):869–895. [PMC free article] [PubMed]
  • MacKrell AJ, Blumberg B, Haynes SR, Fessler JH. The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits. Proc Natl Acad Sci U S A. 1988 Apr;85(8):2633–2637. [PMC free article] [PubMed]
  • Mohler JD. Developmental genetics of the Drosophila egg. I. Identification of 59 sex-linked cistrons with maternal effects on embryonic development. Genetics. 1977 Feb;85(2):259–272. [PMC free article] [PubMed]
  • Mortin MA, Perrimon N, Bonner JJ. Clonal analysis of two mutations in the large subunit of RNA polymerase II of Drosophila. Mol Gen Genet. 1985;199(3):421–426. [PubMed]
  • Nüsslein-Volhard C, Frohnhöfer HG, Lehmann R. Determination of anteroposterior polarity in Drosophila. Science. 1987 Dec 18;238(4834):1675–1681. [PubMed]
  • Papkoff J, Brown AM, Varmus HE. The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway. Mol Cell Biol. 1987 Nov;7(11):3978–3984. [PMC free article] [PubMed]
  • Perrimon N. Clonal Analysis of Dominant Female-Sterile, Germline-Dependent Mutations in DROSOPHILA MELANOGASTER. Genetics. 1984 Dec;108(4):927–939. [PMC free article] [PubMed]
  • Perrimon N, Gans M. Clonal analysis of the tissue specificity of recessive female-sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation Fs(1)K1237. Dev Biol. 1983 Dec;100(2):365–373. [PubMed]
  • Perrimon N, Mahowald AP. Multiple functions of segment polarity genes in Drosophila. Dev Biol. 1987 Feb;119(2):587–600. [PubMed]
  • Perrimon N, Engstrom L, Mahowald AP. The effects of zygotic lethal mutations on female germ-line functions in Drosophila. Dev Biol. 1984 Oct;105(2):404–414. [PubMed]
  • Perrimon N, Engstrom L, Mahowald AP. Developmental genetics of the 2C-D region of the Drosophila X chromosome. Genetics. 1985 Sep;111(1):23–41. [PMC free article] [PubMed]
  • Perrimon N, Smouse D, Miklos GL. Developmental genetics of loci at the base of the X chromosome of Drosophila melanogaster. Genetics. 1989 Feb;121(2):313–331. [PMC free article] [PubMed]
  • Perrimon N, Mohler D, Engstrom L, Mahowald AP. X-linked female-sterile loci in Drosophila melanogaster. Genetics. 1986 Jul;113(3):695–712. [PMC free article] [PubMed]
  • Rijsewijk F, Schuermann M, Wagenaar E, Parren P, Weigel D, Nusse R. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell. 1987 Aug 14;50(4):649–657. [PubMed]
  • Shannon MP, Kaufman TC, Shen MW, Judd BH. Lethality patterns and morphology of selected lethal and semi-lethal mutations in the zeste-white region of Drosophila melanogaster. Genetics. 1972 Dec;72(4):615–638. [PMC free article] [PubMed]
  • Simpson P. Maternal-Zygotic Gene Interactions during Formation of the Dorsoventral Pattern in Drosophila Embryos. Genetics. 1983 Nov;105(3):615–632. [PMC free article] [PubMed]
  • Wright TR. The genetics of embryogenesis in Drosophila. Adv Genet. 1970;15:261–395. [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...