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Genetics. Jan 1989; 121(1): 129–138.
PMCID: PMC1203595

Genotype-Environment Interactions and the Maintenance of Polygenic Variation

Abstract

Genotype-environment interactions may be a potent force maintaining genetic variation in quantitative traits in natural populations. This is shown by a simple model of additive polygenic inheritance in which the additive contributions of alleles vary with the environment. Under simplifying symmetry assumptions, the model implies that the variance of the phenotypes produced across environments by a multilocus genotype decreases as the number of heterozygous loci increases. In the region of an optimal phenotype, the mapping from the quantitative trait into fitness is concave, and the mean fitness of a genotype will increase with the number of heterozygous loci. This leads to balancing selection, polymorphism, and potentially high levels of additive genetic variance, even though all allelic effects remain additive within each specific environment. An important implication of the model is that the variation maintained by genotype-environment interactions is difficult to study with the restricted range of environments represented in typical experiments. In particular, if fluctuations in allelic effects are pervasive, as suggested by the extensive literature on genotype-environment interactions, efforts to estimate genetic parameters in a single environment may be of limited value.

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Selected References

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  • Coyne JA, Beecham E. Heritability of two morphological characters within and among natural populations of Drosophila melanogaster. Genetics. 1987 Dec;117(4):727–737. [PMC free article] [PubMed]
  • Dobzhansky T, Pavlovsky O, Spassky B, Spassky N. Genetics of Natural Populations. Xxiii. Biological Role of Deleterious Recessives in Populations of Drosophila Pseudoobscura. Genetics. 1955 Nov;40(6):781–796. [PMC free article] [PubMed]
  • Dobzhansky T, Levene H. Genetics of Natural Populations. Xxiv. Developmental Homeostasis in Natural Populations of Drosophila Pseudoobscura. Genetics. 1955 Nov;40(6):797–808. [PMC free article] [PubMed]
  • Felsenstein J. The theoretical population genetics of variable selection and migration. Annu Rev Genet. 1976;10:253–280. [PubMed]
  • Gillespie JH. A general model to account for enzyme variation in natural populations. V. The SAS--CFF model. Theor Popul Biol. 1978 Aug;14(1):1–45. [PubMed]
  • Gillespie JH. Pleiotropic overdominance and the maintenance of genetic variation in polygenic characters. Genetics. 1984 Jun;107(2):321–330. [PMC free article] [PubMed]
  • Karlin S. Principles of polymorphism and epistasis for multilocus systems. Proc Natl Acad Sci U S A. 1979 Jan;76(1):541–545. [PMC free article] [PubMed]
  • Kimura M. RULES FOR TESTING STABILITY OF A SELECTIVE POLYMORPHISM. Proc Natl Acad Sci U S A. 1956 Jun;42(6):336–340. [PMC free article] [PubMed]
  • Lande R. The influence of the mating system on the maintenance of genetic variability in polygenic characters. Genetics. 1977 Jun;86(2 Pt 1):485–498. [PMC free article] [PubMed]
  • LEWONTIN RC. THE INTERACTION OF SELECTION AND LINKAGE. II. OPTIMUM MODELS. Genetics. 1964 Oct;50:757–782. [PMC free article] [PubMed]
  • Tachida H, Mukai T. The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. Xix. Genotype-Environment Interaction in Viability. Genetics. 1985 Sep;111(1):43–55. [PMC free article] [PubMed]
  • Turelli M. Heritable genetic variation via mutation-selection balance: Lerch's zeta meets the abdominal bristle. Theor Popul Biol. 1984 Apr;25(2):138–193. [PubMed]
  • Turelli M. Effects of pleiotropy on predictions concerning mutation-selection balance for polygenic traits. Genetics. 1985 Sep;111(1):165–195. [PMC free article] [PubMed]
  • Via S, Lande R. Evolution of genetic variability in a spatially heterogeneous environment: effects of genotype-environment interaction. Genet Res. 1987 Apr;49(2):147–156. [PubMed]

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