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Genetics. Nov 1988; 120(3): 841–847.
PMCID: PMC1203561

Evolution by Gene Duplication and Compensatory Advantageous Mutations

Abstract

Relaxation of selective constraint is thought to play an important role for evolution by gene duplication, in connection with compensatory advantageous mutant substitutions. Models were investigated by incorporating gene duplication by unequal crossing over, selection, mutation and random genetic drift into Monte Carlo simulations. Compensatory advantageous mutations were introduced, and simulations were carried out with and without relaxation, when genes are redundant on chromosomes. Relaxation was introduced by assuming that deleterious mutants have no effect on fitness, so long as one or more genes free of such mutations remain in the array. Compensatory mutations are characterized by the intermediate deleterious step of their substitutions, and therefore relaxation by gene redundancy is important. Through extensive Monte Carlo simulations, it was found that compensatory mutant substitutions require relaxation in addition to gene duplication, when mutant effects are large. However when mutant effects are small, such that the product of selection coefficient and population size is around unity, evolution by compensatory mutation is enhanced by gene duplication even without relaxation.

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Selected References

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  • GERALD PS, EFRON ML. Chemical studies of several varieties of Hb M. Proc Natl Acad Sci U S A. 1961 Nov 15;47:1758–1767. [PMC free article] [PubMed]
  • Gilbert W. Genes-in-pieces revisited. Science. 1985 May 17;228(4701):823–824. [PubMed]
  • Gojobori T, Nei M. Concerted evolution of the immunoglobulin VH gene family. Mol Biol Evol. 1984 Feb;1(2):195–212. [PubMed]
  • Jukes TH. A change in the genetic code in Mycoplasma capricolum. J Mol Evol. 1985;22(4):361–362. [PubMed]
  • KIMURA M. On the probability of fixation of mutant genes in a population. Genetics. 1962 Jun;47:713–719. [PMC free article] [PubMed]
  • Muto A, Yamao F, Osawa S. The genome of Mycoplasma capricolum. Prog Nucleic Acid Res Mol Biol. 1987;34:29–58. [PubMed]
  • Ohta T. Slightly deleterious mutant substitutions in evolution. Nature. 1973 Nov 9;246(5428):96–98. [PubMed]
  • Ohta T. Simulating evolution by gene duplication. Genetics. 1987 Jan;115(1):207–213. [PMC free article] [PubMed]
  • Ohta T. A model of evolution for accumulating genetic information. J Theor Biol. 1987 Jan 21;124(2):199–211. [PubMed]
  • Stenzel P. Opossum Hb chain sequence and neutral mutation theory. Nature. 1974 Nov 1;252(5478):62–63. [PubMed]
  • Tsukihara T, Kobayashi M, Nakamura M, Katsube Y, Fukuyama K, Hase T, Wada K, Matsubara H. Structure-function relationship of [2Fe-2S] ferredoxins and design of a model molecule. Biosystems. 1982;15(3):243–257. [PubMed]
  • Yamao F, Muto A, Kawauchi Y, Iwami M, Iwagami S, Azumi Y, Osawa S. UGA is read as tryptophan in Mycoplasma capricolum. Proc Natl Acad Sci U S A. 1985 Apr;82(8):2306–2309. [PMC free article] [PubMed]

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