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Genetics. May 1987; 116(1): 153–159.
PMCID: PMC1203113

A Test of Neutral Molecular Evolution Based on Nucleotide Data

Abstract

The neutral theory of molecular evolution predicts that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of polymorphism within species. We present here a conservative statistical test of this prediction based on a constant-rate neutral model. The test requires data from an interspecific comparison of at least two regions of the genome and data on levels of intraspecific polymorphism in the same regions from at least one species. The model is rejected for data from the region encompassing the Adh locus and the 5' flanking sequence of Drosophila melanogaster and Drosophila sechellia . The data depart from the model in a direction that is consistent with the presence of balanced polymorphism in the coding region.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Gillespie JH, Langley CH. Are evolutionary rates really variable? J Mol Evol. 1979 Jun 8;13(1):27–34. [PubMed]
  • Hudson RR. Properties of a neutral allele model with intragenic recombination. Theor Popul Biol. 1983 Apr;23(2):183–201. [PubMed]
  • Kreitman M, Aguadé M. Genetic uniformity in two populations of Drosophila melanogaster as revealed by filter hybridization of four-nucleotide-recognizing restriction enzyme digests. Proc Natl Acad Sci U S A. 1986 May;83(10):3562–3566. [PMC free article] [PubMed]
  • Kreitman ME, Aguadé M. Excess polymorphism at the Adh locus in Drosophila melanogaster. Genetics. 1986 Sep;114(1):93–110. [PMC free article] [PubMed]
  • Strobeck C. Expected linkage disequilibrium for a neutral locus linked to a chromosomal arrangement. Genetics. 1983 Mar;103(3):545–555. [PMC free article] [PubMed]
  • Watterson GA. The homozygosity test of neutrality. Genetics. 1978 Feb;88(2):405–417. [PMC free article] [PubMed]
  • Ohta T. Role of very slightly deleterious mutations in molecular evolution and polymorphism. Theor Popul Biol. 1976 Dec;10(3):254–275. [PubMed]

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