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Genetics. Nov 1983; 105(3): 681–721.
PMCID: PMC1202181

Mitochondrial DNA Evolution in Mice

Abstract

This study extends knowledge of mitochondrial DNA (mtDNA) diversity in mice to include 208 animals belonging to eight species in the subgenus Mus. Highly purified mtDNA from each has been subjected to high-resolution restriction mapping with respect to the known sequence of one mouse mtDNA. Variation attributed to base substitutions was encountered at about 200 of the 300 cleavage sites examined, and a length mutation was located in or near the displacement loop. The variability of different functional regions in this genome was as follows, from least to most: ribosomal RNA, transfer RNA, known proteins, displacement loop and unidentified reading frames.—Phylogenetic analysis confirmed the utility of the Sage and Marshall revision of mouse classification, according to which there are at least four species of commensal mice and three species of aboriginal mice in the complex that was formerly considered to be one species. The most thoroughly studied of these species is Mus domesticus, the house mouse of Western Europe and the Mediterranean region, which is the mitochondrial source of all 50 of the laboratory strains examined and of the representatives of wild house mice introduced by Europeans to North and South America during the past few hundred years.—The level of mtDNA variation among wild representatives of (M. musculus) and several other mammalian species. By contrast, among the many laboratory strains that are known or suspected to stem from the pet mouse trade, there is little interstrain variation, most strains having the "old inbred" type of domesticus mtDNA, whose frequency in the 145 wild mice examined is low, about 0.04. Also notable is the apparent homogeneity of mtDNA in domesticus races that have fixed six or more fused chromosomes and the close relationship of some of these mtDNAs to those of karyotypically normal mice.—In addition, this paper discusses fossil and other evidence for the view that in mice, as in many other mammals, the average rate of point mutational divergence in mtDNA is 2–4% per million years. From this, it is estimated that the commensal association between mice and our ancestors began more than a million years ago, i.e., at an early stage in the evolution of Homo erectus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Adolph S, Klein J. Robertsonian variation in Mus musculus from Central Europe Spain, and Scotland. J Hered. 1981 May-Jun;72(3):219–221. [PubMed]
  • Avise JC, Giblin-Davidson C, Laerm J, Patton JC, Lansman RA. Mitochondrial DNA clones and matriarchal phylogeny within and among geographic populations of the pocket gopher, Geomys pinetis. Proc Natl Acad Sci U S A. 1979 Dec;76(12):6694–6698. [PMC free article] [PubMed]
  • Bielschowsky M, Goodall CM. Origin of inbred NZ mouse strains. Cancer Res. 1970 Mar;30(3):834–836. [PubMed]
  • Brown WM. Polymorphism in mitochondrial DNA of humans as revealed by restriction endonuclease analysis. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3605–3609. [PMC free article] [PubMed]
  • Brown WM, George M, Jr, Wilson AC. Rapid evolution of animal mitochondrial DNA. Proc Natl Acad Sci U S A. 1979 Apr;76(4):1967–1971. [PMC free article] [PubMed]
  • Brown WM, Prager EM, Wang A, Wilson AC. Mitochondrial DNA sequences of primates: tempo and mode of evolution. J Mol Evol. 1982;18(4):225–239. [PubMed]
  • Cann RL, Brown WM, Wilson AC. Evolution of human mitochondrial DNA: a preliminary report. Prog Clin Biol Res. 1982;103(Pt A):157–165. [PubMed]
  • Ferris SD, Ritte U, Lindahl KF, Prager EM, Wilson AC. Unusual type of mitochondrial DNA in mice lacking a maternally transmitted antigen. Nucleic Acids Res. 1983 May 11;11(9):2917–2926. [PMC free article] [PubMed]
  • Lindahl KF, Hausmann B. Cytoplasmic inheritance of a cell surface antigen in the mouse. Genetics. 1983 Mar;103(3):483–494. [PMC free article] [PubMed]
  • Greenberg BD, Newbold JE, Sugino A. Intraspecific nucleotide sequence variability surrounding the origin of replication in human mitochondrial DNA. Gene. 1983 Jan-Feb;21(1-2):33–49. [PubMed]
  • Gropp A, Winking H, Redi C, Capanna E, Britton-Davidian J, Noack G. Robertsonian karyotype variation in wild house mice from Rhaeto-Lombardia. Cytogenet Cell Genet. 1982;34(1-2):67–77. [PubMed]
  • Hauswirth WW, Laipis PJ. Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows. Proc Natl Acad Sci U S A. 1982 Aug;79(15):4686–4690. [PMC free article] [PubMed]
  • Wilson SP, Kirshner N. Effects of ascorbic acid, dexamethasone, and insulin on the catecholamine and opioid peptide stores of cultured adrenal medullary chromaffin cells. J Neurosci. 1983 Oct;3(10):1971–1978. [PubMed]
  • Walts LF, Miller J, Davidson MB, Brown J. Perioperative management of diabetes mellitus. Anesthesiology. 1981 Aug;55(2):104–109. [PubMed]
  • Ferris SD, Sage RD, Wilson AC. Evidence from mtDNA sequences that common laboratory strains of inbred mice are descended from a single female. Nature. 1982 Jan 14;295(5845):163–165. [PubMed]
  • King BO, Shade RO, Lansman RA. The use of restriction endonucleases to compare mitochondrial DNA sequences in Mus musculus: a detailed restriction map of mitochondrial DNA from mouse L cells. Plasmid. 1981 May;5(3):313–328. [PubMed]
  • Lansman RA, Avise JC, Huettel MD. Critical experimental test of the possibility of "paternal leakage" of mitochondrial DNA. Proc Natl Acad Sci U S A. 1983 Apr;80(7):1969–1971. [PMC free article] [PubMed]
  • Rice MC, O'Brien SJ. Genetic variance of laboratory outbred Swiss mice. Nature. 1980 Jan 10;283(5743):157–161. [PubMed]
  • Yonekawa H, Moriwaki K, Gotoh O, Hayashi JI, Watanabe J, Miyashita N, Petras ML, Tagashira Y. Evolutionary relationships among five subspecies of Mus musculus based on restriction enzyme cleavage patterns of mitochondrial DNA. Genetics. 1981 Aug;98(4):801–816. [PMC free article] [PubMed]
  • Yonekawa H, Moriwaki K, Gotoh O, Miyashita N, Migita S, Bonhomme F, Hjorth JP, Petras ML, Tagashira Y. Origins of laboratory mice deduced from restriction patterns of mitochondrial DNA. Differentiation. 1982;22(3):222–226. [PubMed]

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