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Genetics. Sep 1983; 105(1): 207–217.
PMCID: PMC1202146

Maximum Likelihood Estimation of the Number of Nucleotide Substitutions from Restriction Sites Data


A simple method of the maximum likelihood estimation of the number of nucleotide substitutions is presented for the case where restriction sites data from many different restriction enzymes are available. An iteration method, based on nucleotide counting, is also developed. This method is simpler than the maximum likelihood method but gives the same estimate. A formula for computing the variance of a maximum likelihood estimate is also presented.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Adams J, Rothman ED. Estimation of phylogenetic relationships from DNA restriction patterns and selection of endonuclease cleavage sites. Proc Natl Acad Sci U S A. 1982 Jun;79(11):3560–3564. [PMC free article] [PubMed]
  • Gojobori T, Ishii K, Nei M. Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide. J Mol Evol. 1982;18(6):414–423. [PubMed]
  • Gotoh O, Hayashi JI, Yonekawa H, Tagashira Y. An improved method for estimating sequence divergence between related DNAs from changes in restriction endonuclease cleavage sites. J Mol Evol. 1979 Dec;14(4):301–310. [PubMed]
  • Kaplan N, Langley CH. A new estimate of sequence divergence of mitochondrial DNA using restriction endonuclease mappings. J Mol Evol. 1979 Nov;13(4):295–304. [PubMed]
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