• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of geneticsGeneticsCurrent IssueInformation for AuthorsEditorial BoardSubscribeSubmit a Manuscript
Genetics. Sep 1982; 102(1): 49–70.
PMCID: PMC1201924

Polycomblike: A Gene That Appears to Be Required for the Normal Expression of the Bithorax and Antennapedia Gene Complexes of DROSOPHILA MELANOGASTER

Abstract

A newly identified gene is described that is required for the maintenance of normal identities in many of the body segments of the fly. The effects of mutants in this gene, which is called Polycomblike (Pcl), suggest that its wild-type allele functions in the regulation of the bithorax gene complex (BX-C) and the Antennapedia gene complex (ANT-C). Evidence in favor of this idea derives from (1) the close correspondence between segmental transformations caused by Pcl mutants and those caused by dominant gain-of-function mutants in the BX-C and ANT-C, (2) the interactions observed between Pcl mutants and mutants in these complexes, and (3) the dependence upon BX-C and ANT-C dosage of the severity of at least one of the transformations caused by Pcl mutants. Arguments are presented that the control of the BX-C and ANT-C by Pcl+ is negative in nature. The results of clonal analysis experiments indicate that, at least for the BX-C, Pcl+ exerts this control until late in development. Since the wild-type allele of another gene, called Polycomb (Pc), has previously been shown to have many of the same properties as Pcl+, it appears that the BX-C and perhaps also the ANT-C are continuously regulated during development by at least two and probably several other genes.

Full Text

The Full Text of this article is available as a PDF (3.1M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Baker BS, Ridge KA. Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster. Genetics. 1980 Feb;94(2):383–423. [PMC free article] [PubMed]
  • Denell RE, Hummels KR, Wakimoto BT, Kaufman TC. Developmental studies of lethality associated with the antennapedia gene complex in Drosophila melanogaster. Dev Biol. 1981 Jan 15;81(1):43–50. [PubMed]
  • Garcia-Bellido A, Dapena J. Induction, detection and characterization of cell differentiation mutants in Drosophila. Mol Gen Genet. 1974;128(2):117–130. [PubMed]
  • Lawrence PA, Struhl G, Morata G. Bristle patterns and compartment boundaries in the tarsi of Drosophila. J Embryol Exp Morphol. 1979 Jun;51:195–208. [PubMed]
  • Lohs-Schardin M, Cremer C, Nüsslein-Volhard C. A fate map for the larval epidermis of Drosophila melanogaster: localized cuticle defects following irradiation of the blastoderm with an ultraviolet laser microbeam. Dev Biol. 1979 Dec;73(2):239–255. [PubMed]
  • Morata G, Kerridge S. Sequential functions of the bithorax complex of Drosophila. Nature. 1981 Apr 30;290(5809):778–781. [PubMed]
  • Santamaria P, García-Bellido A. Localization and growth pattern of the tergite Anlage of Drosophila. J Embryol Exp Morphol. 1972 Oct;28(2):397–417. [PubMed]
  • Wakimoto BT, Kaufman TC. Analysis of larval segmentation in lethal genotypes associated with the antennapedia gene complex in Drosophila melanogaster. Dev Biol. 1981 Jan 15;81(1):51–64. [PubMed]

Articles from Genetics are provided here courtesy of Genetics Society of America

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...