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Genetics. Jul 1982; 101(3-4): 519–531.
PMCID: PMC1201875

Selfish DNA: A Sexually-Transmitted Nuclear Parasite


A quantitative population genetics model for the evolution of transposable genetic elements is developed. This model shows that "selfish" DNA sequences do not have to be selectively neutral at the organismic level; indeed, such DNA can produce major deleterious effects in the host organism and still spread through the population. The model can be used to explain the evolution of introns within eukaryotic genes; this explanation does not invoke a long-term evolutionary advantage for introns, nor does it depend on the hypothesis that eukaryotic gene structure may be an evolutionary relic. Transposable genes that carried information specifying sexual reproduction in the host organism would favor their own spread. Consequently, it is tempting to speculate that some of the genes controlling sex were originally selected as transposable elements.

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Selected References

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  • Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, et al. Sequence and organization of the human mitochondrial genome. Nature. 1981 Apr 9;290(5806):457–465. [PubMed]
  • Crick F. Split genes and RNA splicing. Science. 1979 Apr 20;204(4390):264–271. [PubMed]
  • Doolittle WF, Sapienza C. Selfish genes, the phenotype paradigm and genome evolution. Nature. 1980 Apr 17;284(5757):601–603. [PubMed]
  • Gutz H, Leslie JF. Gene conversion: a hitherto overlooked parameter in population genetics. Genetics. 1976 Aug;83(4):861–866. [PMC free article] [PubMed]
  • Harshey RM, Bukhari AI. A mechanism of DNA transposition. Proc Natl Acad Sci U S A. 1981 Feb;78(2):1090–1094. [PMC free article] [PubMed]
  • Kleckner N. Translocatable elements in procaryotes. Cell. 1977 May;11(1):11–23. [PubMed]
  • Ohta T. Population genetics of selfish DNA. Nature. 1981 Aug 13;292(5824):648–649. [PubMed]
  • Wahli W, Dawid IB, Ryffel GU, Weber R. Vitellogenesis and the vitellogenin gene family. Science. 1981 Apr 17;212(4492):298–304. [PubMed]

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