• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of genitmedLink to Publisher's site
Genitourin Med. Aug 1995; 71(4): 244–246.
PMCID: PMC1195522

Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis.

Abstract

OBJECTIVE--To determine the kinetics of azithromycin in cervical mucus and plasma. SUBJECTS AND METHODS--Azithromycin concentrations were determined in plasma and mucus samples from 20 women with cervical chlamydial infection one, seven and fourteen days after a single oral 1.0 g dose. RESULTS--In mucus, all measurable azithromycin concentrations were above the minimal inhibitory concentration against Chlamydia trachomatis on day 7 as well as on day 14. CONCLUSION--The high cervical mucus concentrations of azithromycin can explain the high clinical and microbiological efficacy.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (569K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Scieux C, Bianchi A, Chappey B, Vassias I, Pérol Y. In-vitro activity of azithromycin against Chlamydia trachomatis. J Antimicrob Chemother. 1990 Jan;25 (Suppl A):7–10. [PubMed]
  • Slaney L, Chubb H, Ronald A, Brunham R. In-vitro activity of azithromycin, erythromycin, ciprofloxacin and norfloxacin against Neisseria gonorrhoeae, Haemophilus ducreyi, and Chlamydia trachomatis. J Antimicrob Chemother. 1990 Jan;25 (Suppl A):1–5. [PubMed]
  • Foulds G, Shepard RM, Johnson RB. The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother. 1990 Jan;25 (Suppl A):73–82. [PubMed]
  • Nilsen A, Halsos A, Johansen A, Hansen E, Tørud E, Moseng D, Anestad G, Størvold G. A double blind study of single dose azithromycin and doxycycline in the treatment of chlamydial urethritis in males. Genitourin Med. 1992 Oct;68(5):325–327. [PMC free article] [PubMed]
  • Martin DH, Mroczkowski TF, Dalu ZA, McCarty J, Jones RB, Hopkins SJ, Johnson RB. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial Infections Study Group. N Engl J Med. 1992 Sep 24;327(13):921–925. [PubMed]
  • Lauharanta J, Saarinen K, Mustonen MT, Happonen HP. Single-dose oral azithromycin versus seven-day doxycycline in the treatment of non-gonococcal urethritis in males. J Antimicrob Chemother. 1993 Jun;31 (Suppl E):177–183. [PubMed]
  • Steingrímsson O, Olafsson JH, Thórarinsson H, Ryan RW, Johnson RB, Tilton RC. Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men. Sex Transm Dis. 1994 Jan-Feb;21(1):43–46. [PubMed]
  • Lister PJ, Balechandran T, Ridgway GL, Robinson AJ. Comparison of azithromycin and doxycycline in the treatment of non-gonococcal urethritis in men. J Antimicrob Chemother. 1993 Jun;31 (Suppl E):185–192. [PubMed]
  • Ripa KT, Mårdh PA. Cultivation of Chlamydia trachomatis in cycloheximide-treated mccoy cells. J Clin Microbiol. 1977 Oct;6(4):328–331. [PMC free article] [PubMed]
  • Drew RH, Gallis HA. Azithromycin--spectrum of activity, pharmacokinetics, and clinical applications. Pharmacotherapy. 1992;12(3):161–173. [PubMed]
  • Retsema JA, Bergeron JM, Girard D, Milisen WB, Girard AE. Preferential concentration of azithromycin in an infected mouse thigh model. J Antimicrob Chemother. 1993 Jun;31 (Suppl E):5–16. [PubMed]
  • Girard D, Bergeron JM, Milisen WB, Retsema JA. Comparison of azithromycin, roxithromycin, and cephalexin penetration kinetics in early and mature abscesses. J Antimicrob Chemother. 1993 Jun;31 (Suppl E):17–28. [PubMed]
  • Foulds G, Johnson RB. Selection of dose regimens of azithromycin . J Antimicrob Chemother. 1993 Jun;31 (Suppl E):39–50. [PubMed]
  • Grob PR. Antibiotic prescribing practices and patient compliance in the community. Scand J Infect Dis Suppl. 1992;83:7–14. [PubMed]

Articles from Genitourinary Medicine are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...