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Genitourin Med. Aug 1993; 69(4): 265–269.
PMCID: PMC1195084

Mycoplasma genitalium: a cause of male urethritis?


BACKGROUND--Male urethritis may be caused by mycoplasmas. Since Mycoplasma genitalium has previously been isolated from the urethra of two men with non-gonococcal urethritis (NGU), it was the aim of the study further to elucidate its role by measuring the prevalence of this organism in men with NGU. MATERIAL AND METHODS--The polymerase chain reaction was used. Two different sequences of the gene coding for the main adhesin MgPa were amplified. Urethral, rectal, and throat samples from 99 male sexually transmitted disease (STD) patients with and without urethritis were studied. RESULTS--M genitalium DNA was demonstrated in 17/99 (17%) of the urethral swabs, but in none of the rectal and throat swabs. Significantly more patients with urethritis (13/52) were positive for M genitalium DNA than were patients without urethritis (4/47) (p < 0.03). In those with urethritis M genitalium DNA was found more often in Chlamydia trachomatis negative NGU (12/34) than in those with chlamydial NGU (1/14) (p = 0.05). Attempts to culture M genitalium from the PCR positive specimens were unsuccessful. CONCLUSION--M genitalium DNA was found significantly more often in male STD patients with non-chlamydial NGU than in men with chlamydial urethritis (p = 0.05) and in men without urethritis (p = 0.003), suggesting that M genitalium may be a cause of NGU. M genitalium DNA was not demonstrated in any of the throat or rectal swabsindicating that the urogenital tract is probably the primary site of infection or colonisation of this species.

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  • Bowie WR, Alexander ER, Holmes KK. Etiologies of postgonococcal urethritis in homosexual and heterosexual men: roles of Chlamydia trachomatis and Ureaplasma urealyticum. Sex Transm Dis. 1978 Oct-Dec;5(4):151–154. [PubMed]
  • Coufalik ED, Taylor-Robinson D, Csonka GW. Treatment of nongonococcal urethritis with rifampicin as a means of defining the role of Ureaplasma urealyticum. Br J Vener Dis. 1979 Feb;55(1):36–43. [PMC free article] [PubMed]
  • Taylor-Robinson D, McCormack WM. The genital mycoplasmas (first of two parts). N Engl J Med. 1980 May 1;302(18):1003–1010. [PubMed]
  • Taylor-Robinson D, Tully JG, Furr PM, Cole RM, Rose DL, Hanna NF. Urogenital mycoplasma infections of man: a review with observations on a recently discovered mycoplasma. Isr J Med Sci. 1981 Jul;17(7):524–530. [PubMed]
  • Tully JG, Taylor-Robinson D, Cole RM, Rose DL. A newly discovered mycoplasma in the human urogenital tract. Lancet. 1981 Jun 13;1(8233):1288–1291. [PubMed]
  • Taylor-Robinson D, Furr PM, Hetherington CM. The pathogenicity of a newly discovered human mycoplasma (strain G37) for the genital tract of marmosets. J Hyg (Lond) 1982 Dec;89(3):449–455. [PMC free article] [PubMed]
  • Taylor-Robinson D, Tully JG, Barile MF. Urethral infection in male chimpanzees produced experimentally by Mycoplasma genitalium. Br J Exp Pathol. 1985 Feb;66(1):95–101. [PMC free article] [PubMed]
  • Tully JG, Taylor-Robinson D, Rose DL, Furr PM, Graham CE, Barile MF. Urogenital challenge of primate species with Mycoplasma genitalium and characteristics of infection induced in chimpanzees. J Infect Dis. 1986 Jun;153(6):1046–1054. [PubMed]
  • Taylor-Robinson D, Furr PM, Hanna NF. Microbiological and serological study of non-gonococcal urethritis with special reference to Mycoplasma genitalium. Genitourin Med. 1985 Oct;61(5):319–324. [PMC free article] [PubMed]
  • Ashall F, Bramwell ME, Harris H. A new marker for human cancer cells. 1 The Ca antigen and the Ca1 antibody. Lancet. 1982 Jul 3;2(8288):1–6. [PubMed]
  • Lind K, Lindhardt BO, Schütten HJ, Blom J, Christiansen C. Serological cross-reactions between Mycoplasma genitalium and Mycoplasma pneumoniae. J Clin Microbiol. 1984 Dec;20(6):1036–1043. [PMC free article] [PubMed]
  • Hooton TM, Roberts MC, Roberts PL, Holmes KK, Stamm WE, Kenny GE. Prevalence of Mycoplasma genitalium determined by DNA probe in men with urethritis. Lancet. 1988 Feb 6;1(8580):266–268. [PubMed]
  • Baseman JB, Dallo SF, Tully JG, Rose DL. Isolation and characterization of Mycoplasma genitalium strains from the human respiratory tract. J Clin Microbiol. 1988 Nov;26(11):2266–2269. [PMC free article] [PubMed]
  • Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science. 1985 Dec 20;230(4732):1350–1354. [PubMed]
  • Jensen JS, Uldum SA, Søndergård-Andersen J, Vuust J, Lind K. Polymerase chain reaction for detection of Mycoplasma genitalium in clinical samples. J Clin Microbiol. 1991 Jan;29(1):46–50. [PMC free article] [PubMed]
  • Kristensen GB, Bollerup AC, Lind K, Mårdh PA, Ladehoff P, Larsen S, Marushak A, Rasmussen P, Rolschau J, Skoven I, et al. Infections with Neisseria gonorrhoeae and Chlamydia trachomatis in women with acute salpingitis. Genitourin Med. 1985 Jun;61(3):179–184. [PMC free article] [PubMed]
  • Lind K, Kristensen GB, Bollerup AC, Ladehoff P, Larsen S, Marushak A, Rasmussen P, Rolschau J, Skoven I, Sørensen T, et al. Importance of Mycoplasma hominis in acute salpingitis assessed by culture and serological tests. Genitourin Med. 1985 Jun;61(3):185–189. [PMC free article] [PubMed]
  • Tully JG, Whitcomb RF, Clark HF, Williamson DL. Pathogenic mycoplasmas: cultivation and vertebrate pathogenicity of a new spiroplasma. Science. 1977 Mar 4;195(4281):892–894. [PubMed]
  • Tully JG, Baseman JB. Mycoplasma. Lancet. 1991 May 25;337(8752):1296–1296. [PubMed]
  • Dallo SF, Chavoya A, Su CJ, Baseman JB. DNA and protein sequence homologies between the adhesins of Mycoplasma genitalium and Mycoplasma pneumoniae. Infect Immun. 1989 Apr;57(4):1059–1065. [PMC free article] [PubMed]
  • Longo MC, Berninger MS, Hartley JL. Use of uracil DNA glycosylase to control carry-over contamination in polymerase chain reactions. Gene. 1990 Sep 1;93(1):125–128. [PubMed]
  • Uldum SA, Jensen JS, Søndergård-Andersen J, Lind K. Enzyme immunoassay for detection of immunoglobulin M (IgM) and IgG antibodies to Mycoplasma pneumoniae. J Clin Microbiol. 1992 May;30(5):1198–1204. [PMC free article] [PubMed]
  • Evans AS. Causation and disease: the Henle-Koch postulates revisited. Yale J Biol Med. 1976 May;49(2):175–195. [PMC free article] [PubMed]
  • Taylor-Robinson D. The role of mycoplasmas in non-gonococcal urethritis: a review. Yale J Biol Med. 1983 Sep-Dec;56(5-6):537–543. [PMC free article] [PubMed]
  • Razin S, Tully JG, Rose DL, Barile MF. DNA cleavage patterns as indicators of genotypic heterogeneity among strains of Acholeplasma and Mycoplasma species. J Gen Microbiol. 1983 Jun;129(6):1935–1944. [PubMed]

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