Logo of genitmedLink to Publisher's site
Genitourin Med. Aug 1989; 65(4): 263–268.
PMCID: PMC1194366

Should male consorts of women with bacterial vaginosis be treated?

Abstract

Nitroimidazoles have been shown to be the drugs of choice to treat women with bacterial vaginosis, but the recurrence rate is high. Some workers have suggested that the recurrence of symptoms may in fact be reinfection by male consorts, but no controlled studies have been undertaken to confirm this. In an international, multicentre, randomised, double blind trial, the recurrence rate was studied in 241 women with a clinical diagnosis of bacterial vaginosis. All women were treated with 2 g metronidazole twice at an interval of two days. The patients were randomly allocated to two groups, one contained 123 women, whose consorts were given the same dose of metronidazole, the other consisted of 118 women whose consorts were given inert but identical placebo tablets. The women were evaluated at weeks 1, 4, and 12 after treatment. At week 1, the cure rate was 97% (115/119) in women whose consorts had been treated and 98% (111/113) in the others. At week 4 bacterial vaginosis had recurred in 17% (19/112) of women whose consorts had been treated and in 13% (14/106) of those whose consorts had received placebo. At week 12 the recurrence rates were 21% (20/95) in women with treated consorts, and 16% (15/95) in the others. The differences in recurrence rates between the two groups of women were not significant. In conclusion, treating the sexual partners of women with bacterial vaginosis does not seem to increase the cure rate.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Blackwell AL, Barlow D. Anaerobic vaginosis. Clinical and diagnostic aspects. Scand J Urol Nephrol Suppl. 1984;86:129–133. [PubMed]
  • Amsel R, Totten PA, Spiegel CA, Chen KC, Eschenbach D, Holmes KK. Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med. 1983 Jan;74(1):14–22. [PubMed]
  • Pheifer TA, Forsyth PS, Durfee MA, Pollock HM, Holmes KK. Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole. N Engl J Med. 1978 Jun 29;298(26):1429–1434. [PubMed]
  • GARDNER HL, DUKES CD. Haemophilus vaginalis vaginitis: a newly defined specific infection previously classified non-specific vaginitis. Am J Obstet Gynecol. 1955 May;69(5):962–976. [PubMed]
  • Jerve F, Berdal TB, Bohman P, Smith CC, Evjen OK, Gjønnaess H, Gaasemyr M, Hausken L, Hesla K, Hoftvedt E, et al. Metronidazole in the treatment of non-specific vaginitis (NSV). Br J Vener Dis. 1984 Jun;60(3):171–174. [PMC free article] [PubMed]
  • Gästrin B, Kallings LO, Marcetic A. The survival time for different bacteria in various transport media. Acta Pathol Microbiol Scand. 1968;74(3):371–380. [PubMed]
  • Totten PA, Amsel R, Hale J, Piot P, Holmes KK. Selective differential human blood bilayer media for isolation of Gardnerella (Haemophilus) vaginalis. J Clin Microbiol. 1982 Jan;15(1):141–147. [PMC free article] [PubMed]
  • Blackwell AL, Fox AR, Phillips I, Barlow D. Anaerobic vaginosis (non-specific vaginitis): clinical, microbiological, and therapeutic findings. Lancet. 1983 Dec 17;2(8364):1379–1382. [PubMed]
  • Piot P, Van Dyck E, Godts P, Vanderheyden J. A placebo-controlled, double-blind comparison of tinidazole and triple sulfonamide cream for the treatment of nonspecific vaginitis. Am J Obstet Gynecol. 1983 Sep 1;147(1):85–89. [PubMed]
  • Piot P. Bacterial vaginosis. An evaluation of treatment. Scand J Urol Nephrol Suppl. 1984;86:229–235. [PubMed]
  • Taylor-Robinson D. The bacteriology of Gardnerella vaginalis. Scand J Urol Nephrol Suppl. 1984;86:41–55. [PubMed]
  • Eschenbach DA, Critchlow CW, Watkins H, Smith K, Spiegel CA, Chen KC, Holmes KK. A dose-duration study of metronidazole for the treatment of nonspecific vaginosis. Scand J Infect Dis Suppl. 1983;40:73–80. [PubMed]
  • Swedberg J, Steiner JF, Deiss F, Steiner S, Driggers DA. Comparison of single-dose vs one-week course of metronidazole for symptomatic bacterial vaginosis. JAMA. 1985 Aug 23;254(8):1046–1049. [PubMed]
  • Weaver CH, Mengel MB. Bacterial vaginosis. J Fam Pract. 1988 Aug;27(2):207–215. [PubMed]
  • Vejtorp M, Bollerup AC, Vejtorp L, Fanøe E, Nathan E, Reiter A, Andersen ME, Strømsholt B, Schrøder SS. Bacterial vaginosis: a double-blind randomized trial of the effect of treatment of the sexual partner. Br J Obstet Gynaecol. 1988 Sep;95(9):920–926. [PubMed]
  • Piot P, Van Dyck E, Godts P, Vanderheyden J. The vaginal microbial flora in non-specific vaginitis. Eur J Clin Microbiol. 1982 Oct;1(5):301–306. [PubMed]
  • Holst E, Mårdh PA, Thelin I. Recovery of anaerobic curved rods and Gardnerella vaginalis from the urethra of men, including male heterosexual consorts of female carriers. Scand J Urol Nephrol Suppl. 1984;86:173–177. [PubMed]
  • Dawson SG, Ison CA, Csonka G, Easmon CS. Male carriage of Gardnerella vaginalis. Br J Vener Dis. 1982 Aug;58(4):243–245. [PMC free article] [PubMed]
  • Hallén A, Påhlson C, Forsum U. Bacterial vaginosis in women attending STD clinic: diagnostic criteria and prevalence of Mobiluncus spp. Genitourin Med. 1987 Dec;63(6):386–389. [PMC free article] [PubMed]
  • Baldson MJ, Jackson D. Metronidazole metabolite and Gardnerella vaginalis (Corynebacterium vaginale) Lancet. 1981 May 16;1(8229):1112–1112. [PubMed]
  • Shanker S, Munro R. Sensitivity of Gardnerella vaginalis to metabolites of metronidazole and tinidazole. Lancet. 1982 Jan 16;1(8264):167–167. [PubMed]
  • Easmon CS, Ison CA, Kaye CM, Timewell RM, Dawson SG. Pharmacokinetics of metronidazole and its principal metabolites and their activity against Gardnerella vaginalis. Br J Vener Dis. 1982 Aug;58(4):246–249. [PMC free article] [PubMed]

Articles from Genitourinary Medicine are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...