• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jphysiolThe Journal of Physiology SiteMembershipSubmissionJ Physiol
J Physiol. Sep 1983; 342: 383–397.
PMCID: PMC1193965

Responses in muscle afferent fibres of slow conduction velocity to contractions and ischaemia in the cat.

Abstract

The aim of the study was to find out to what extent muscle receptors with slowly conducting afferent fibres (group III and IV) are activated by muscular contractions of moderate force, and what kind of muscle afferents could mediate the pain of ischaemic exercise. In chloralose-anaesthetized cats, the impulse activity of single afferent units from the triceps surae muscle was recorded from dorsal root filaments during muscular contractions with intact blood supply and after occlusion of the muscle artery. Two types of responses were observed to contractions without muscular ischaemia. One was characterized by sudden onset and a graded response amplitude to contractions of increasing force. In most cases stretching the muscle was also an effective stimulus. Units showing this response behaviour were labelled c.s.m (contraction-sensitive with mechanical mechanism of activation). The other response type had a more delayed onset and often outlasted the exercise period; because of the unknown mechanism of activation, units of this kind were labelled c.s.x. The proportion of c.s.m receptors was significantly higher amongst group III than amongst group IV units. During ischaemic contractions of comparable force the c.s.m and c.s.x receptors exhibited an unchanged or a decreased response amplitude. Under these conditions another receptor type (N, for nociceptive) was activated which did not respond to contractions with intact blood supply. Vigorous activations during ischaemic work were only observed in group IV receptors. The majority of the 131 group III and IV units tested did not respond to contractions at all. These contraction-insensitive (c.i.) endings probably comprised different receptor populations (nociceptors, thermoreceptors, low-threshold mechanoreceptors). It is concluded that the various central nervous effects of muscular exercise without ischaemia which are known to be due to raised activity in thin muscle afferents (e.g. cardiopulmonary adjustments, spinal locomotor reflexes) are probably produced by the c.s.m and c.s.x types. The pain of ischaemic contractions is most likely mediated by the N receptors most of which possess non-myelinated afferent fibres.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.7M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Alam M, Smirk FH. Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. J Physiol. 1937 Jun 3;89(4):372–383. [PMC free article] [PubMed]
  • Alam M, Smirk FH. Observations in man on a pulse-accelerating reflex from the voluntary muscles of the legs. J Physiol. 1938 Mar 14;92(2):167–177. [PMC free article] [PubMed]
  • ASMUSSEN E, NIELSEN M. EXPERIMENTS ON NERVOUS FACTORS CONTROLLING RESPIRATION AND CIRCULATION DURING EXERCISE EMPLOYING BLOCKING OF THE BLOOD FLOW. Acta Physiol Scand. 1964 Jan-Feb;60:103–111. [PubMed]
  • BESSOU P, DEJOURS P, LAPORTE Y. Effets ventilatoires réflexes de la stimulation de fibres afférentes de grand diamètre d'origine musculaire, chez le chat. C R Seances Soc Biol Fil. 1959;153(3):447–481. [PubMed]
  • BESSOU P, LAPORTE Y. Activation des fibres afférentes amyéliniques d'origine musculaire. C R Seances Soc Biol Fil. 1958;152(11):1587–1590. [PubMed]
  • COLLE J, GYBELS J. Etude des réactions tensionnelles, respiratoires et corticales produites par l'excitation électrique des fibres afférentes d'un nerf somatique. Arch Int Physiol Biochim. 1957 Dec;65(4):547–567. [PubMed]
  • Coote JH, Dodds WN. The baroreceptor reflex and the cardiovascular changes associated with sustained muscular contraction in the cat. Pflugers Arch. 1976 May 12;363(2):167–173. [PubMed]
  • Coote JH, Hilton SM, Perez-Gonzalez JF. The reflex nature of the pressor response to muscular exercise. J Physiol. 1971 Jul;215(3):789–804. [PMC free article] [PubMed]
  • Digiesi V, Bartoli V, Dorigo B. Effect of a proteinase inhibitor on intermittent claudication or on pain at rest in patients with peripheral arterial disease. Pain. 1975 Dec;1(4):385–389. [PubMed]
  • Ellaway PH, Murphy PR, Tripathi A. Closely coupled excitation of gamma-motoneurones by group III Muscle afferents with low mechanical threshold in the cat. J Physiol. 1982 Oct;331:481–498. [PMC free article] [PubMed]
  • Fisher ML, Nutter DO. Cardiovascular reflex adjustments to static muscular contractions in the canine hindlimb. Am J Physiol. 1974 Mar;226(3):648–655. [PubMed]
  • Hník P, Holas M, Krekule I, Kŭriz N, Mejsnar J, Smiesko V, Ujec E, Vyskocil F. Work-induced potassium changes in skeletal muscle and effluent venous blood assessed by liquid ion-exchanger microelectrodes. Pflugers Arch. 1976 Mar 11;362(1):85–94. [PubMed]
  • Kniffki KD, Mense S, Schmidt RF. Responses of group IV afferent units from skeletal muscle to stretch, contraction and chemical stimulation. Exp Brain Res. 1978 Apr 14;31(4):511–522. [PubMed]
  • KOIZUMI K, USHIYAMA J, BROOKS CM. Muscle afferents and activity of respiratory neurons. Am J Physiol. 1961 Apr;200:679–684. [PubMed]
  • Kumazawa T, Mizumura K. Thin-fibre receptors responding to mechanical, chemical, and thermal stimulation in the skeletal muscle of the dog. J Physiol. 1977 Dec;273(1):179–194. [PMC free article] [PubMed]
  • McCloskey DI, Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol. 1972 Jul;224(1):173–186. [PMC free article] [PubMed]
  • Mense S. Nervous outflow from skeletal muscle following chemical noxious stimulation. J Physiol. 1977 May;267(1):75–88. [PMC free article] [PubMed]
  • Mense S. Muscular nociceptors. J Physiol (Paris) 1977 Sep;73(3):233–240. [PubMed]
  • Mizumura K, Kumazawa T. Reflex respiratory response induced py chemical stimulation of muscle afferents. Brain Res. 1976 Jun 11;109(2):402–406. [PubMed]
  • MORGAN DP, KAO F, LIM TP, GRODINS FS. Temperature and respiratory responses in exercise. Am J Physiol. 1955 Dec;183(3):454–458. [PubMed]
  • PAINTAL AS. Functional analysis of group III afferent fibres of mammalian muscles. J Physiol. 1960 Jul;152:250–270. [PMC free article] [PubMed]
  • Paterson WD. Circulatory and respiratory changes in response to muscular exercise in man. J Physiol. 1928 Dec 20;66(4):323–345. [PMC free article] [PubMed]
  • Pérez-González JF, Coote JH. Activity of muscle afferents and reflex circulatory responses to exercise. Am J Physiol. 1972 Jul;223(1):138–143. [PubMed]
  • Rowell LB. Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev. 1974 Jan;54(1):75–159. [PubMed]
  • Sato A, Sato Y, Schmidt RF. Heart rate changes reflecting modifications of efferent cardiac sympathetic outflow by cutaneous and muscle afferent volleys. J Auton Nerv Syst. 1981 Sep;4(3):231–247. [PubMed]
  • Schibye B, Mitchell JH, Payne FC, Saltin B. Blood pressure and heart rate response to static exercise in relation to electromyographic activity and force development. Acta Physiol Scand. 1981 Sep;113(1):61–66. [PubMed]
  • STAUNTON HP, TAYLOR SH, DONALD KW. THE EFFECT OF VASCULAR OCCLUSION ON THE PRESSOR RESPONSE TO STATIC MUSCULAR WORK. Clin Sci. 1964 Oct;27:283–291. [PubMed]
  • Stegemann J, Kenner T. A theory on heart rate control by muscular metabolic receptors. Arch Kreislaufforsch. 1971 Mar-Apr;64(3):185–214. [PubMed]
  • Tibes U. Reflex inputs to the cardiovascular and respiratory centers from dynamically working canine muscles. Some evidence for involvement of group III or IV nerve fibers. Circ Res. 1977 Sep;41(3):332–341. [PubMed]
  • Wildenthal K, Mierzwiak DS, Skinner NS, Jr, Mitchell JH. Potassium-induced cardiovascular and ventilatory reflexes from the dog hindlimb. Am J Physiol. 1968 Sep;215(3):542–548. [PubMed]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...