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Journal List > J Physiol > v.380; Nov 1986

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J Physiol. 1986 November; 380: 405–414.
PMCID: PMC1182945
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Kidney function in rats with corticomedullary nephrocalcinosis: effects of alterations in dietary calcium and magnesium.
A K Al-Modhefer, J C Atherton, H O Garland, H J Singh, and J Walker
Abstract
Single-nephron and whole-kidney function were studied in female rats with corticomedullary nephrocalcinosis, and in animals where the lesion had been prevented either by a dietary magnesium supplement or by using a diet with a calcium:phosphorus ratio in excess of 1. At the single-nephron level, rats with nephrocalcinosis had prolonged tubular fluid transit times. Proximal transit time was 19.42 +/- 1.98 (mean +/- S.E. of mean) vs. 11.58 +/- 0.19 s for controls; distal transit time was 62.64 +/- 9.16 vs. 31.50 +/- 1.03 s for controls. Although single-nephron function is altered in nephrocalcinosis, data obtained from rats in metabolism cages indicate that whole-kidney function is largely unaffected by the lesion.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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