Inhibition of insulin-like growth factor-1 receptor signaling enhances growth-inhibitory and proapoptotic effects of gefitinib (Iressa) in human breast cancer cells

Anne Camirand, Mahvash Zakikhani, Fiona Young, Michael Pollak

Breast Cancer Res. 2005; 7(4): R570–R579. Published online 2005 April 12. doi: 10.1186/bcr1028

PMCID:: PMC1175059

Abstract Full Text PDF–700K

Is Cited by the Following 11 Articles in this Archive:

A Phase I/II Study of Erlotinib in Combination with the Anti-Insulin-Like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (Cixutumumab) in Patients with Advanced Non-small Cell Lung Cancer

Andrew Weickhardt, Robert Doebele, Ana Oton, Janice Lettieri, DeLee Maxson, Michele Reynolds, Amy Brown, Mary K. Jackson, Grace Dy, Araba Adjei, Gerald Fetterly, Xian Lu, Wilbur Franklin, Marileila Varella-Garcia, Fred R. Hirsch, Murry W. Wynes, Hagop Youssoufian, Alex Adjei, D. Ross Camidge

J Thorac Oncol. Author manuscript; available in PMC 2012 May 23.

Published in final edited form as: J Thorac Oncol. 2012 February; 7(2): 419–426. doi: 10.1097/JTO.0b013e31823c5b11

PMCID:: PMC3358820

Abstract Full Text PDF–900K Supplementary Material

Activation of the insulin-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells

Mark J. Jameson, Andrew D. Beckler, Linnea E. Taniguchi, Amir Allak, Lisa B. Van Wagner, Nora G. Lee, William C. Thomsen, Matthew A. Hubbard, Christopher Y. Thomas

Mol Cancer Ther. Author manuscript; available in PMC 2012 November 1.

Published in final edited form as: Mol Cancer Ther. 2011 November; 10(11): 2124–2134. Published online 2011 August 30. doi: 10.1158/1535-7163.MCT-11-0294

PMCID:: PMC3213311

Free in PMC on 2012/11/01

A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis

Robert K Dearth, Isere Kuiatse, Yu-Fen Wang, Lan Liao, Susan G Hilsenbeck, Powel H Brown, Jianming Xu, Adrian V Lee

BMC Cancer. 2011; 11: 377. Published online 2011 August 25. doi: 10.1186/1471-2407-11-377

PMCID:: PMC3189189

Abstract Full Text PDF–827K

Receptor-Tyrosine-Kinase-Targeted Therapies for Head and Neck Cancer

Lisa A. Elferink, Vicente A. Resto

J Signal Transduct. 2011; 2011: 982879. Published online 2011 June 7. doi: 10.1155/2011/982879

PMCID:: PMC3135278

Abstract Full Text PDF–660K

Dual Inhibition of Epidermal Growth Factor Receptor and Insulin-like Growth Factor Receptor I Reduces Angiogenesis and Tumor Growth in Cutaneous Squamous Cell Carcinoma

Chad E. Galer, Christina L. Corey, Zhuoying Wang, Maher N. Younes, Fernando Gomez-Rivera, Samar A. Jasser, Dale L. Ludwig, Adel K. El-Naggar, Randal S. Weber, Jeffrey N. Myers

Head Neck. Author manuscript; available in PMC 2012 February 1.

Published in final edited form as: Head Neck. 2011 February; 33(2): 189–198. doi: 10.1002/hed.21419

PMCID:: PMC3010504

Abstract Full Text PDF–605K

A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors

Dana Inbar-Rozensal, Asher Castiel, Leonid Visochek, David Castel, Françoise Dantzer, Shai Izraeli, Malka Cohen-Armon

Breast Cancer Res. 2009; 11(6): R78. Published online 2009 November 9. doi: 10.1186/bcr2445

PMCID:: PMC2815540

Abstract Full Text PDF–3.7M Supplementary Material

Inhibition of the Insulin-like Growth Factor-1 Receptor (IGF1R) Tyrosine Kinase as a Novel Cancer Therapy Approach

Rongshi Li, Alan Pourpak, Stephan W. Morris

J Med Chem. Author manuscript; available in PMC 2010 August 1.

Published in final edited form as: J Med Chem. 2009 August 27; 52(16): 4981–5004. doi: 10.1021/jm9002395

PMCID:: PMC2888655

Full Text PDF–413K

Cixutumumab

Kevin P McKian, Paul Haluska

Expert Opin Investig Drugs. Author manuscript; available in PMC 2010 September 15.

Published in final edited form as: Expert Opin Investig Drugs. 2009 July; 18(7): 1025–1033. doi: 10.1517/13543780903055049

PMCID:: PMC2939377

Abstract Full Text PDF–910K

Insulin-like Growth Factor-1 Receptor and ErbB Kinase Inhibitor Combinations Block Proliferation and Induce Apoptosis through Cyclin D1 Reduction and Bax Activation

Julie L. Wilsbacher, Qian Zhang, Lora A. Tucker, Robert D. Hubbard, George S. Sheppard, Nwe Y. Bamaung, Steve D. Fidanze, Gary T. Wang, Xiaoming Hu, Steven K. Davidsen, Randy L. Bell, Jieyi Wang

J Biol Chem. 2008 August 29; 283(35): 23721–23730. doi: 10.1074/jbc.M708360200